Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Ya-min Tian"'
Autor:
Matthew E Cockman, Kerstin Lippl, Ya-Min Tian, Hamish B Pegg, William D Figg Jnr, Martine I Abboud, Raphael Heilig, Roman Fischer, Johanna Myllyharju, Christopher J Schofield, Peter J Ratcliffe
Publikováno v:
eLife, Vol 8 (2019)
Human and other animal cells deploy three closely related dioxygenases (PHD 1, 2 and 3) to signal oxygen levels by catalysing oxygen regulated prolyl hydroxylation of the transcription factor HIF. The discovery of the HIF prolyl-hydroxylase (PHD) enz
Externí odkaz:
https://doaj.org/article/70d88ea4f82c4443ab41453328102032
Autor:
Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Ya-Min Tian, Martine I. Abboud, Wei Ge, Carmen Domene, François-Xavier Cantrelle, Isabelle Landrieu, Adam P. Hardy, Christopher W. Pugh, Peter J. Ratcliffe, Timothy D. W. Claridge, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The response to hypoxia involves multiple genes regulated by the hypoxia inducible transcription factors (HIFs), whose stability is regulated by prolyl hydroxylation. Here the authors provide a molecular basis for the substrate selectivity of the HIF
Externí odkaz:
https://doaj.org/article/bcbb0397431d45b6a10192b43d152868
Autor:
Mun Chiang Chan, Onur Atasoylu, Emma Hodson, Anthony Tumber, Ivanhoe K H Leung, Rasheduzzaman Chowdhury, Verónica Gómez-Pérez, Marina Demetriades, Anna M Rydzik, James Holt-Martyn, Ya-Min Tian, Tammie Bishop, Timothy D W Claridge, Akane Kawamura, Christopher W Pugh, Peter J Ratcliffe, Christopher J Schofield
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132004 (2015)
As part of the cellular adaptation to limiting oxygen availability in animals, the expression of a large set of genes is activated by the upregulation of the hypoxia-inducible transcription factors (HIFs). Therapeutic activation of the natural human
Externí odkaz:
https://doaj.org/article/270e114bd2074970b400b2da1562426e
Autor:
Rafik Salama, Norma Masson, Peter Simpson, Lina Katrin Sciesielski, Min Sun, Ya-Min Tian, Peter John Ratcliffe, David Robert Mole
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134645 (2015)
General activation of hypoxia-inducible factor (HIF) pathways is classically associated with adverse prognosis in cancer and has been proposed to contribute to oncogenic drive. In clear cell renal carcinoma (CCRC) HIF pathways are upregulated by inac
Externí odkaz:
https://doaj.org/article/0365a0a4df53412d8170589c5f6df354
Autor:
Li-Juan Deng, Ke-Shu Zhou, Li-Hong Liu, Ming-Zhi Zhang, Zhi-Ming Li, Chun-Yan Ji, Wei Xu, Ting Liu, Bing Xu, Xin Wang, Su-Jun Gao, Hui-Lai Zhang, Yu Hu, Yan Li, Ying Cheng, Hai-Yan Yang, Jun-Ning Cao, Zunmin Zhu, Jian-Da Hu, Wei Zhang, Hong-Mei Jing, Kai-Yang Ding, Xiang-Yang Zhang, Renbin Zhao, Bin Zhang, Ya-Min Tian, Yong-Ping Song, Yu-Qin Song, Jun Zhu
Publikováno v:
Blood Advances.
Relapsed or refractory (r/r) mantle cell lymphoma (MCL) is an aggressive B-cell malignancy with poor prognosis. Bruton's tyrosine kinase (BTK) is a mediator of B-cell receptor signaling and is associated with the development of B-cell lymphomas. Pati
Autor:
Ya-Min Tian1,2, Holdship, Philip3, Trang Quynh To3, Ratcliffe, Peter J.1,2,4 peter.ratcliffe@ndm.ox.ac.uk, Keeley, Thomas P.1,2 thomas.keeley@ndm.ox.ac.uk
Publikováno v:
Journal of Biological Chemistry. Sep2023, Vol. 299 Issue 9, p1-12. 12p.
Autor:
Xin-xin Cao, Jie Jin, Cheng-cheng Fu, Shu-hua Yi, Wei-li Zhao, Zi-min Sun, Wei Yang, Deng-ju Li, Guo-hui Cui, Jian-da Hu, Ting Liu, Yong-ping Song, Bing Xu, Zun-min Zhu, Wei Xu, Ming-zhi Zhang, Ya-min Tian, Bin Zhang, Ren-bin Zhao, Dao-bin Zhou
Publikováno v:
EClinicalMedicine. 52
Orelabrutinib is a novel, small molecule, selective irreversible Bruton tyrosine kinase inhibitor. The purpose of this study was to evaluate the efficacy and safety of orelabrutinib in patients with relapsed or refractory Waldenström's macroglobulin
Publikováno v:
Zhongguo gu shang = China journal of orthopaedics and traumatology. 34(7)
To investigate the effect and safety of ulnar osteochondroma resection, ulnar minimally invasive osteotomy, external fixation and ulnar lengthening in the treatment of forearm deformity of metaphyseal extension of ulna.From August 2005 to December 20
Autor:
Johanna Myllyharju, Roman Fischer, William D Figg Jnr, Kerstin Lippl, Raphael Heilig, Christopher J. Schofield, Matthew E. Cockman, Ya-Min Tian, Martine I. Abboud, Hamish B Pegg, Peter J. Ratcliffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ed9be5c54cd1c00ac767438b749412d
https://doi.org/10.7554/elife.46490.072
https://doi.org/10.7554/elife.46490.072
Autor:
Kar Kheng Yeoh, Myung Kyu Lee, Armin Thalhammer, Ya Min Tian, Rasheduzzaman Chowdhury, Luke A. McNeill, Akane Kawamura, Jasmin Mecinović, Muhammad Mukram Mohamed Mackeen, Marina Demetriades, Christopher J. Schofield, Esther C. Y. Woon, Peter J. Ratcliffe, Ineke P. Stolze, Mun Chiang Chan
Publikováno v:
Organic & Biomolecular Chemistry, 11, 5, pp. 732-45
Org. Biomol. Chem.
Organic & Biomolecular Chemistry, 11, 732-45
Org. Biomol. Chem.
Organic & Biomolecular Chemistry, 11, 732-45
Inhibition of the hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD or EGLN enzymes) is of interest for the treatment of anemia and ischemia-related diseases. Most PHD inhibitors work by binding to the single ferrous ion and competing with 2-ox