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Supplementary Figures S1-S12 from Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation

Differentiation induction activity of vibsanine A and its analogues on HL-60 Cells (S1); Characterization of differentiation-inducing activity of vibsanine A (S2); Vibsanine A-induced growth inhibition of myeloid leukemia cells (S3); Gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304ab586364e63819856663ab3920a6b
https://doi.org/10.1158/0008-5472.22411308

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Data from Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation

All-trans retinoic acid (ATRA)-based cell differentiation therapy has been successful in treating acute promyelocytic leukemia, a unique subtype of acute myeloid leukemia (AML). However, other subtypes of AML display resistance to ATRA-based treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9c50441b1d3af23e6e042c660f626ec
https://doi.org/10.1158/0008-5472.c.6508191.v1

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Dimethyl sulfoxide, a potent oral radioprotective agent, confers radioprotection of hematopoietic stem and progenitor cells independent of apoptosis

Autor: Xiaolan Liu, Zuyin Yu, Zongchao Zuo, Yingying Tang, Wenting Zhang, Yuwen Cong, Limei Wang, Ya-Jun Shan, Renjun Peng

Publikováno v: Free Radical Biology and Medicine. 153:1-11

In mass casualty events involving radiation exposure, there is a substantial unmet need for identifying and developing an orally bioavailable agent that can be used to protect the hematopoietic stem cell pool and regenerate hematopoiesis after radiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c323dce9b76613ac991dfc1935a3c209
https://doi.org/10.1016/j.freeradbiomed.2020.03.021

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17α-Ethinyl-androst-5-ene-3β, 17β-diol, a Novel Potent Oral Radioprotective Agent, Confers Radioprotection of Hematopoietic Stem and Progenitor Cells in a Granulocyte Colony-Stimulating Factor–Independent Manner

Autor: Li-Rong Yi, Renjun Peng, Cheng Zhang, Zongchao Zuo, Yuwen Cong, Limei Wang, Fan Bai, Zuyin Yu, Li Zhongtang, Ya-Jun Shan, Rifang Yang, Chao Yang

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 103:217-228

Purpose The risk of radiation exposure is considered to have increased in recent years. For convenience and simple administration, development of an effective orally administered radioprotective agent is highly desirable. The steroid 5-androstene-3β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850fc2bfd2fca23b2d1a661a3f1e97fb
https://doi.org/10.1016/j.ijrobp.2018.08.002

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Single-Dose Administration of Recombinant Human Thrombopoietin Mitigates Total Body Irradiation-Induced Hematopoietic System Injury in Mice and Nonhuman Primates

Autor: Zuyin Yu, Xin-Ru Wang, Qing-Liang Luo, Xing Shen, Jin-kun Yang, Ya-Jun Shan, Hong-Ling Ou, Guo-Lin Xiong, Xue-wen Zhang, Shuang Xing, Yuwen Cong

Publikováno v: International journal of radiation oncology, biology, physics. 108(5)

Purpose Recombinant human thrombopoietin (rhTPO) has been evaluated as a therapeutic intervention for radiation-induced myelosuppression. However, the immunogenicity induced by a repeated-dosing strategy raises concerns about the therapeutic use of r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1421c9e73e1870e25f162414d9ec93
https://pubmed.ncbi.nlm.nih.gov/32758640

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Dimethyl Sulfoxide Prevents Radiation-Induced Oral Mucositis Through Facilitating DNA Double-Strand Break Repair in Epithelial Stem Cells

Autor: Ya-Jun Shan, Chao Yang, Hong-wei Tang, Renjun Peng, Ping-Kun Zhou, Limei Wang, Zuyin Yu, Yuwen Cong, Fan Bai

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 102:1577-1589

Purpose Oral mucositis is one of the most prevalent side effects in patients undergoing radiation therapy for head and neck cancers. Current therapeutic agents such as palifermin recombinant human keratinocyte growth factor and amifostine do not effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c62059f8a01d24c3fb5554776450082
https://doi.org/10.1016/j.ijrobp.2018.07.2010

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Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn

Autor: Zuyin Yu, Qin-Shi Zhao, Hong-Ling Ou, Lu Zhang, Fang-Min Wang, Xing Shen, Yu-Wen Cong, He Xiao, Xin-Ru Wang, Guo-Lin Xiong, Shuang Xing, Ya-Jun Shan

Publikováno v: Biochemical and Biophysical Research Communications. 502:110-115

Differentiation therapies have been proposed to overcome the impaired cell differentiation in acute myeloid leukemia (AML). However, thus far the all-trans retinoic acid-based differentiation therapy has been the only successful modality in treating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a385596cb26278741ea350440e6138c
https://doi.org/10.1016/j.bbrc.2018.05.129

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Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation

Publikováno v: Cancer Research. 76:2698-2709

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356092539a5e3bbdc3b263eff9c4aece
https://doi.org/10.1158/0008-5472.can-15-1616

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