Zobrazeno 1 - 10
of 254
pro vyhledávání: '"Ya-jie Tang"'
Autor:
Yuan-Mei Wang, Huang Tang, Ya-Jie Tang, Juan Liu, Yu-Fang Yin, Ya-Ling Tang, Yao-Guang Feng, Hong-Feng Gu
Publikováno v:
Journal of Advanced Research, Vol 63, Iss , Pp 195-206 (2024)
Introduction: Atherosclerosis, a major contributor to cardiovascular disease, remains a significant health concern worldwide. While previous research has shown that acid-sensing ion channel 1 (ASIC1) impedes macrophage cholesterol efflux, its precise
Externí odkaz:
https://doaj.org/article/2766660ceca342afa880008de586d130
Autor:
Zhong Li, Lilan Zhang, Kangwei Xu, Yuanyuan Jiang, Jieke Du, Xingwang Zhang, Ling-Hong Meng, Qile Wu, Lei Du, Xiaoju Li, Yuechan Hu, Zhenzhen Xie, Xukai Jiang, Ya-Jie Tang, Ruibo Wu, Rey-Ting Guo, Shengying Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Diterpene synthase VenA is responsible for assembling venezuelaene A with a unique 5-5-6-7 tetracyclic skeleton from geranylgeranyl pyrophosphate. VenA also demonstrates substrate promiscuity by accepting geranyl pyrophosphate and farnesyl p
Externí odkaz:
https://doaj.org/article/edd63d160b41477f8f37ff2ed99ab384
Publikováno v:
Tetrahedron Chem, Vol 8, Iss , Pp 100052- (2023)
Indolines, characterized by their diverse biological activities and structural significance, have garnered considerable attention in the realms of natural product synthesis and drug discovery. Concurrently, the incorporation of fluorine atoms into or
Externí odkaz:
https://doaj.org/article/5415812f583c4202a09f113b33a4a75b
Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B
Autor:
Peng Zhang, Lijuan Zhang, Xukai Jiang, Xiao-tong Diao, Shuang Li, Dan-dan Li, Zheng Zhang, Junqiang Fang, Ya-jie Tang, Da-lei Wu, Changsheng Wu, Yue-zhong Li
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Zhang et al. identify three hot regions of macrolide glycosyltransferase BsGT-1, that can play a role in epothilone B and sugar donor specificity. Further mutagenesis of BsGT-1 showed that specificity could be engineered and when the mutations were i
Externí odkaz:
https://doaj.org/article/dee3c165cd3f49388524a75c04cf1e4d
Publikováno v:
mSystems, Vol 7, Iss 5 (2022)
ABSTRACT The two-component system CpxRA can sense environmental stresses and regulate transcription of a wide range of genes for the purpose of adaptation. Despite extensive research on this system, the identification of the CpxR regulon is not syste
Externí odkaz:
https://doaj.org/article/3bf04c92caab4cd18390653b4d178327
Autor:
Lei Wang, Dan-Dan Du, Zong-Xue Zheng, Peng-Fei Shang, Xiao-Xia Yang, Chao Sun, Xiao-Yan Wang, Ya-Jie Tang, Xiu-Li Guo
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Graphical Abstract
Externí odkaz:
https://doaj.org/article/828b31790b934950bbb1069a24f03633
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Fatty acid oxidation (FAO) is the emerging hallmark of cancer metabolism because certain tumor cells preferentially utilize fatty acids for energy. Lymph node metastasis, the most common way of tumor metastasis, is much indispensable for gra
Externí odkaz:
https://doaj.org/article/65251b02dbb6439a800ccc0ec4e30a9d
Publikováno v:
Biotechnology for Biofuels, Vol 14, Iss 1, Pp 1-10 (2021)
Abstract Background Succinic acid (SA) is a crucial metabolic intermediate and platform chemical. Development of biobased processes to achieve sustainable SA production has attracted more and more attention in biotechnology industry. Yarrowia lipolyt
Externí odkaz:
https://doaj.org/article/302a860bc2d040208c3f74cac059f2fe
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies. Fibroblasts, which represent a predominant cell type in t
Externí odkaz:
https://doaj.org/article/6a678bd01b204138936e41b34fc534cd
Autor:
Ming-xin Cao, Wei-long Zhang, Xiang-hua Yu, Jia-shun Wu, Xin-wei Qiao, Mei-chang Huang, Ke Wang, Jing-biao Wu, Ya-Jie Tang, Jian Jiang, Xin-hua Liang, Ya-ling Tang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-18 (2020)
Abstract Background Human papillomavirus (HPV)-positive oral squamous cell carcinoma (OSCC) is increasing worldwide with typically higher grade and stage, while better prognosis. microRNAs (miRNAs) has been shown to play a critical role in cancer, ho
Externí odkaz:
https://doaj.org/article/b24544e1ee3141d8a07bb3020eaecd8b