Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ya-Zhuo Hu"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Mitochondrial dysfunction (MD) is increasingly recognized as a key pathophysiological contributor in Alzheimer disease (AD). As differential MD genes expression may serve as either a causative factor or a consequence in AD, and ex
Externí odkaz:
https://doaj.org/article/1bb273f72bea4c00aaa62752bd269ef4
Autor:
Kai Zheng, Fan Hu, Yang Zhou, Juan Zhang, Jie Zheng, Chuan Lai, Wan Xiong, Ke Cui, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Guo Chen, Heng-Ye Man, Dan Liu, Youming Lu, Ling-Qiang Zhu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Several micro RNAs have been shown to be deregulated in brain tissue or sera from individuals with Alzheimer’s disease and in AD mouse models. The authors show that miR-135a-5p is downregulated in excitatory pyramidal neurons from AD mice and that
Externí odkaz:
https://doaj.org/article/3366a3bed29948729d65876a46ebc7a7
Autor:
Yuan⁃yuan WANG, Ming⁃wei ZHU, Lu⁃ning WANG, Hong⁃hong ZHANG, Ya⁃zhuo HU, Zhi⁃tao HAN, Ying⁃han ZHANG
Publikováno v:
Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 19, Iss 8, Pp 573-580 (2019)
Objective To evaluate the expression of P62 protein in the characteristic pathological changes of common neurodegenerative diseases and to explore its significance in pathological diagnosis. Methods Eleven cases of neurodegenerative diseases and 3 no
Externí odkaz:
https://doaj.org/article/aa64dea8a59d4074b89f813cead7587e
Autor:
Yan⁃jun GUO, Lu⁃ning WANG, Ming⁃wei ZHU, Hong⁃hong ZHANG, Ya⁃zhuo HU, Zhi⁃tao HAN, Wei⁃qin ZHAO, De⁃xin WANG
Publikováno v:
Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 10, Iss 4, Pp 483-487 (2010)
Objective To investigate the characteristics of α⁃synucleinopathy in the spinal cord of patients with Alzheimer's disease (AD). Methods HE staining and immunohistochemistry staining were used to determine the expression of α⁃synuclein in the sp
Externí odkaz:
https://doaj.org/article/0a07dab8916d40bd8447db5b6a109a11
Autor:
Lan-Ting Zhou, Dan Liu, Hui-Cong Kang, Lu Lu, He-Zhou Huang, Wen-Qing Ai, Yang Zhou, Man-Fei Deng, Hao Li, Zhi-Qiang Liu, Wei-Feng Zhang, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Jun Jia, Avijite Kumer Sarkar, Saldin Sharaydeh, Jie Wang, Heng-Ye Man, Marcel Schilling, Lars Bertram, Youming Lu, Ziyuan Guo, Ling-Qiang Zhu
Publikováno v:
Science Advances. 9
The neuron-glia cross-talk is critical to brain homeostasis and is particularly affected by neurodegenerative diseases. How neurons manipulate the neuron-astrocyte interaction under pathological conditions, such as hyperphosphorylated tau, a patholog
Autor:
Dong Xie, Kai Chen, Ling-Qiang Zhu, Wan Xiong, Youming Lu, Jian-Guo Chen, Peter T. Nelson, Zhi Tao Han, Wen Dai Bao, Wang-Xia Wang, Heng-Ye Man, Jing Wang, Fudi Wang, Xiao Ting Zhou, Dan Liu, Fan Hu, Ya Zhuo Hu, Pei Pang, Hong Hong Zhang
Publikováno v:
Cell Death and Differentiation
Iron homeostasis disturbance has been implicated in Alzheimer’s disease (AD), and excess iron exacerbates oxidative damage and cognitive defects. Ferroptosis is a nonapoptotic form of cell death dependent upon intracellular iron. However, the invol
Publikováno v:
Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-Based Complementary and Alternative Medicine, Vol 2019 (2019)
Evidence-Based Complementary and Alternative Medicine, Vol 2019 (2019)
BuPiHeWei (BPHW) decoction, a classic Traditional Chinese Medicinal (TCM) prescription, has been widely used in clinical practice to relieve digestive symptoms caused by chemotherapy, such as diarrhea and vomiting. The present study aimed to investig
Publikováno v:
Journal of Gastroenterology and Hepatology. 27:273-278
Background and Aim: As a newly identified subset of T helper cells, T-helper 17 cells (Th17) are major mediators of inflammation-associated disease. Some reports have revealed significantly increased Th17 cells in hepatitis B virus-infected patients,
Publikováno v:
Chinese medical journal. 125(6)
Adult stem cells provide a promising alternative for the treatment of injured tissues. We aimed to investigate the effect of in vivo transplantation of bone marrow mesenchymal stem cells (BMMSCs) on injured gastric mucosa in rats.The gastric ulcer in
Publikováno v:
Yao xue xue bao = Acta pharmaceutica Sinica. 46(9)
This study is to investigate the effect of baicalin (BL) against oxidative injury stress of SH-SY5Y cells induced by H2O2 and the possible mechanism. SH-SY5Y cells were pre-incubated with baicalin (25, 50, and 100 micromol x L(-1)) for 12 h prior to