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Increased intracellular Cl− concentration promotes ongoing inflammation in airway epithelium

Publikováno v: Mucosal Immunology. 11:1149-1157

Airway epithelial cells harbor the capacity of active Cl- transepithelial transport and play critical roles in modulating innate immunity. However, whether intracellular Cl- accumulation contributes to relentless airway inflammation remains largely u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d24dd649ccfd577664ac23d6ba2ad9ed
https://doi.org/10.1038/s41385-018-0013-8

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Relaxant Effect of Sodium Tanshinone IIA Sulphonate on Mouse Tracheal Smooth Muscle

Autor: Peng-Xiao Chen, Yu-Li Luo, Jiehong Huang, Yun-Xin Zhu, Wen-Liang Zhou, Dong-Dong Gao, Fang Wei, Ya-Xia Tan, Xiao-Wen Chen, Yi-Lin Zhang, Xiong-Hao Wu, Lei Zhao, Jia-Wen Xu

Publikováno v: Planta medica. 83(7)

Sodium tanshinone IIA sulphonate, a water-soluble derivative of tanshinone IIA, has been proven to possess versatile biological properties, but its pharmacological effect on tracheal smooth muscle remains elusive. This paper presents a study on the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b8ccdd606fa42b7e455ab9debb14b9
https://pubmed.ncbi.nlm.nih.gov/27936472

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Longitudinal profile of antibodies against SARS‐coronavirus in SARS patients and their clinical significance

Autor: Changwen Ke, Nanshan Zhong, Rongchang Chen, Chaoda Cai, Moira Chan-Yeung, Ya-xia Tan, Kefang Lai, Hong-ying Mo, Xiao-lan Ren, Guang-qiao Zeng, Hui Li

Publikováno v: Respirology (Carlton, Vic.)

Background: Severe acute respiratory syndrome (SARS) is a newly discovered disease caused by a novel coronavirus. The present study studied the longitudinal profile of antibodies against SARS-coronavirus (SARS-CoV) in SARS patients and evaluated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5022c53d56f4fa2cd326cea796fc8f0b
http://europepmc.org/articles/PMC7192223

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Progress in Chemokine-Like Factor 1 Research over the Past 10 Years: From Promoting Inflammatory Cell Trafficking to Inhibiting Allergic Airway Inflammation

Autor: Ya-xia Tan

Publikováno v: Journal of Allergy & Therapy.

Chemokine-like factor 1 (CKLF1) is a cytokine, first described in 2001. CKLF1 is highly expressed in the lung and leukocytes. Recombinant CKLF1 has chemotactic activity on leukocytes, and stimulates the proliferation of murine skeletal muscle cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb83ca19de1aff2dc4b0c7f185fc6380
https://doi.org/10.4172/2155-6121.s1-006

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[Outcome and significance of pulmonary pathological changes induced by a single intramuscular injection of chemokine-like factor 1 in mice]

Autor: Ya-xia, Tan, Tong, Yang, Qiao-li, Chen, Feng, Ye, Mei, Jiang, Shi-yue, Li, Jing, Ding, Quan-sheng, Song, Xian-ting, Li, Yan, Tang, Nan-shan, Zhong

Publikováno v: Zhonghua yi xue za zhi. 89(34)

To investigate the significance of pathological changes in murine lung by a single intramuscular injection of chemokine-like factor 1 (CKLF1).A total of 120 gender-matched BALB/c mice were randomly and evenly divided into treatment group and control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::71c6389a7f21cbe0b6f2265b7a3b0884
https://pubmed.ncbi.nlm.nih.gov/20137695

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[Expression and significance of severe acute respiratory syndrome associated coronavirus (SARS-CoV)-X4 protein in lungs of SARS patients]

Autor: Ya-xia, Tan, Tao, Chen, Shu-qing, Zhong, Yi-min, Li, Ying-yu, Chen, Xiao-yan, Qiu, Xiao-ning, Mo, Quan-sheng, Song, Qi-ni, Gan, Ying-ying, Gu, Hong-ying, Mo, Wei, Luo, Xin-ming, He, Mu-chang, Liu, Nan-shan, Zhong

Publikováno v: Zhonghua nei ke za zhi. 45(3)

To investigate the significance of severe acute respiratory syndrome associated coronavirus (SARS-CoV)-X4 protein expression in lungs of patients with SARS.Pathological features of the lungs from 4 SARS patients were examined and the expression of SA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::34027f6665ac56cd6d8eb6f6b07b9107
https://pubmed.ncbi.nlm.nih.gov/16624149

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Evaluation by indirect immunofluorescent assay and enzyme linked immunosorbent assay of the dynamic changes of serum antibody responses against severe acute respiratory syndrome coronavirus

Autor: Hong-ying, Mo, Jun, Xu, Xiao-lan, Ren, Guang-qiao, Zeng, Ya-xia, Tan, Rong-chang, Chen, Moira, Chan-Yeung, Nan-shan, Zhong

Publikováno v: Chinese medical journal. 118(6)

Severe acute respiratory syndrome coronavirus (SARS-CoV) is a newly emerging virus that gives rise to SARS patients with high rates of infectivity and fatality. To study the humoral immune responses to SARS-CoV, the authors evaluated IgG and IgM spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f0ac50741833fba6df9c4fc1ade0d410
https://pubmed.ncbi.nlm.nih.gov/15788123

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The protein X4 of severe acute respiratory syndrome-associated coronavirus is expressed on both virus-infected cells and lung tissue of severe acute respiratory syndrome patients and inhibits growth of Balb/c 3T3 cell line

Autor: Ying-yu, Chen, Bao, Shuang, Ya-xia, Tan, Min-jie, Meng, Pu, Han, Xiao-ning, Mo, Quan-sheng, Song, Xiao-yan, Qiu, Xin, Luo, Qi-ni, Gan, Xin, Zhang, Ying, Zheng, Shun-ai, Liu, Xiao-ning, Wang, Nan-shan, Zhong, Da-long, Ma

Publikováno v: Chinese medical journal. 118(4)

The genome of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) includes sequences encoding the putative protein X4 (ORF8, ORF7a), consisting of 122 amino acids. The deduced sequence contains a probable cleaved signal peptide se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21e087c8760800c365620cc12c47b8bd
https://pubmed.ncbi.nlm.nih.gov/15740663

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Chemokine-like factor 1, a novel cytokine, contributes to airway damage, remodeling and pulmonary fibrosis

Autor: Ya-xia, Tan, Wen-ling, Han, Ying-yu, Chen, Neng-tai, Ouyang, Yan, Tang, Feng, Li, Pei-guo, Ding, Xiao-lan, Ren, Guang-qiao, Zeng, Jing, Ding, Tong, Zhu, Da-long, Ma, Nan-shan, Zhong

Publikováno v: Chinese medical journal. 117(8)

Chemokine-like factor 1 (CKLF1) was recently identified as a novel cytokine. The full-length CKLF1 cDNA contains 530 bp encoding 99 amino acid residues with a CC motif similar to that of other CC family chemokines. Recombinant CKLF1 exhibits chemotac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22ecc648f777ac47273ed80d28a42fc2
https://pubmed.ncbi.nlm.nih.gov/15361282

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