Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Ya-Qiu Long"'
Publikováno v:
JACS Au, Vol 4, Iss 11, Pp 4206-4211 (2024)
Externí odkaz:
https://doaj.org/article/4da69a3f5bd34fcca007a140e8dbdbab
Publikováno v:
Chinese Journal of Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12b6ddadad216ca37c00c5c5759c479d
https://doi.org/10.1002/cjoc.202300106
https://doi.org/10.1002/cjoc.202300106
Publikováno v:
Chemical Communications. 58:8340-8343
An unprecedented metal-free unactivated C(Ph)–C(alkyl) bond cleavage triggered by a tandem radical 5-ipso trig cyclization and 1,2-carbonyl migration to synthesize pharmaceutically important 4-quinolone scaffolds has been developed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c6fae0e15acb8c995cc7d7a646ea5e
https://doi.org/10.1039/d2cc02245a
https://doi.org/10.1039/d2cc02245a
Publikováno v:
Chemical communications (Cambridge, England). 58(97)
A concise synthesis of the tetrahydropyranyl side chain of verucopeptin, an antitumor antibiotic cyclodepsipeptide efficacious against multidrug-resistant cancer in vivo, is achieved using 12 steps in the longest linear sequence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698304959c62972259b2b08baa89a849
https://pubmed.ncbi.nlm.nih.gov/36350039
https://pubmed.ncbi.nlm.nih.gov/36350039
Autor:
Cheng Chen, Shi-Meng Guo, Yuanjun Sun, He Li, Nan Hu, Kun Yao, Huxin Ni, Zhikan Xia, Bin Xu, Xin Xie, Ya-Qiu Long
Publikováno v:
European Journal of Medicinal Chemistry. 251:115267
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::324e8f916cdb011ee50135953d6e1aa2
https://doi.org/10.1016/j.ejmech.2023.115267
https://doi.org/10.1016/j.ejmech.2023.115267
Autor:
Jiao Kong, Ya-Qiu Long
Publikováno v:
RSC Med Chem
Src homology 2 domain-containing protein tyrosine phosphatase (SHP2) is a non-receptor protein tyrosine phosphatase encoded by the Ptpn11 gene, which regulates cell growth, differentiation and apoptosis via modulating various signaling pathways, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7812e677a8f232282f5581e9a53edeab
https://europepmc.org/articles/PMC8942255/
https://europepmc.org/articles/PMC8942255/
Publikováno v:
Journal of medicinal chemistry. 65(1)
Although a myriad of bioorthogonal prodrugs have been developed, very few of them present both fast reaction kinetics and complete cleavage. Herein, we report a new bioorthogonal prodrug strategy with both fast reaction kinetics (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6638491227ff9da0ecbb7f614e5164
https://pubmed.ncbi.nlm.nih.gov/34963283
https://pubmed.ncbi.nlm.nih.gov/34963283
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:3559-3572
The chemokine CC receptor subtype 2 (CCR2) has attracted intensive interest for drug development in diverse therapeutic areas, including chronic inflammatory diseases, diabetes, neuropathic pain, atherogenesis and cancer. By employing a cut-and-sew s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9035137e78df1ac651e2655b3a0acfb0
https://doi.org/10.1016/j.bmc.2018.05.027
https://doi.org/10.1016/j.bmc.2018.05.027
Publikováno v:
Tetrahedron Letters. 59:2214-2228
Bioorthogonal chemical groups to tag naturally occurring biomolecules in their native setting is a powerful tool for studying and manipulating biological processes, whereby unique functional groups incorporated into target biomolecules can be detecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34eb064c273bea124f127a6c6347a5e6
https://doi.org/10.1016/j.tetlet.2018.04.058
https://doi.org/10.1016/j.tetlet.2018.04.058
Autor:
Ruiming Rong, Long Li, Liping Li, Lexi Zhang, Long Zheng, Miao Lin, Ya-Qiu Long, Chao Zhang, Shang Huang, Chao Hu, Tongyu Zhu, Cheng Yang
Publikováno v:
Molecular Medicine Reports
Renal ischemia-reperfusion injury (IRI) is present in numerous diseases and is observed following certain treatments, including renal transplantation. Preventing tubular epithelial cells (TECs) from undergoing apoptosis is vital for treatment of rena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b752fbd1b8df2dd63ad85722185804
https://doi.org/10.3892/mmr.2017.7588
https://doi.org/10.3892/mmr.2017.7588