Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ya-Qing Lou"'
Autor:
Zhi-Yuan Zhang, Hua Zhang, Dan Liu, Ying-Yuan Lu, Xin Wang, Pu Li, Ya-Qing Lou, Bao-Xue Yang, Ya-Xin Lou, Chuang Lu, Qiang Zhang, Guo-Liang Zhang
Publikováno v:
Pharmaceutics, Vol 10, Iss 3, p 124 (2018)
Methyl 3-amino-6-methoxythieno [2,3-b] quinoline-2-carboxylate (PU-48) is a novel diuretic urea transporter inhibitor. The aim of this study is to investigate the profile of plasma pharmacokinetics, tissue distribution, and excretion by oral dosing o
Externí odkaz:
https://doaj.org/article/86afe8975448430b85c73df2bd6b9a1c
Autor:
Sheng-Ju Yin, Min-Ji Wei, Pu Li, Ya-Qing Lou, Xuan Wei, Zi-Sheng Kang, Suo-Di Zhai, Xin Wang, Yuan Lu, Zhi-Yuan Zhang, Guo-Liang Zhang
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 123:464-473
Mizolastine is a selective histamine H1 receptor antagonist for chronic urticaria or allergic rhinitis. We investigated whether the variant genotypes of metabolic enzymes UGT1A1, CYP3A5 and transporter ABCB1 influence pharmacokinetic phenotype of sub
Autor:
Min-Ji Wei, Guang-Zhao Qi, Guo-Liang Zhang, Hui-Min Qi, Xin Wang, Ya-Qing Lou, Pu Zhang, Sheng-Ju Yin, Pu Li, Yuan Lu, Chuang Lu
Publikováno v:
Pharmacogenetics and Genomics. 27:125-134
Pioglitazone is a thiazolidinedione antihyperglycemic drug with insulin-sensitizing properties. We investigated whether the variant genotypes of cytochrome P450 2C8 (CYP2C8), CYP2C9, CYP3A5 and transporter ABCB1 influence the pharmacokinetic phenotyp
Autor:
Dan Liu, Zhi-Yuan Zhang, Qiang Zhang, Guo-Liang Zhang, Ying-Yuan Lu, Hua Zhang, Xin Wang, Baoxue Yang, Chuang Lu, Ya-Xin Lou, Pu Li, Ya-Qing Lou
Publikováno v:
Pharmaceutics
Volume 10
Issue 3
Pharmaceutics, Vol 10, Iss 3, p 124 (2018)
Volume 10
Issue 3
Pharmaceutics, Vol 10, Iss 3, p 124 (2018)
Methyl 3-amino-6-methoxythieno [2,3-b] quinoline-2-carboxylate (PU-48) is a novel diuretic urea transporter inhibitor. The aim of this study is to investigate the profile of plasma pharmacokinetics, tissue distribution, and excretion by oral dosing o
Autor:
Xin Wang, Qiang Li, Ya-Qing Lou, Hai-Xu Cheng, Shu-Mei Wang, Yu Ding, Ying-Yuan Lu, Hong Ren, Guo-Liang Zhang
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 123
The compound 3,4‑dichlorophenyl‑propenoyl‑sec.‑butylamine (3,4‑DCPB) is an antiepileptic drug. The purpose of the present research was to identify cytochrome P450 (CYP450) responsible for the metabolism of 3,4‑DCPB and evaluate the effect
Autor:
Ying-Yuan Lu, Guo-Liang Zhang, Xiao-Wei Wang, Chuang Lu, Wenbing Dai, Qiang Zhang, Pu Li, Xin Wang, Jun-Yi Liu, Ya-Qing Lou
Publikováno v:
Drug development and industrial pharmacy. 44(2)
The objective of this study was to investigate the effect of crystalline state and a formulation of self-nanoemulsifying drug delivery system (SNEDDS) on oral bioavailability of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1), a novel non-nucleoside re
Autor:
Qiang Zhang, Pu Li, Xiao-Wei Wang, Guo-Liang Zhang, Chuang Lu, Ying-Yuan Lu, Xin Wang, Wenbing Dai, Jun-Yi Liu, Ya-Qing Lou
Publikováno v:
Archives of pharmacal research. 39(7)
The purpose of this study was to characterize the disposition, distribution, excretion and plasma protein binding of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) in rats. Concentrations of W-1 within biological samples were determined using a valida
Publikováno v:
Journal of Clinical Pharmacy and Therapeutics. 37:364-369
Summary What is known and Objective: Cytochrome P450 2C19 (CYP2C19) and CYP2D6 are important xenobiotic metabolic enzymes and both show considerable genetic variability between Orientals and Caucasians. There are known marked heterogeneity in suscept
Publikováno v:
The Journal of Clinical Pharmacology. 50:775-784
Interindividual variability of cytochrome P450 (CYP) 3A inhibition by grapefruit juice was investigated in relation to CYP3A5 and multidrug resistance gene (MDR) 1 genetic polymorphisms in Chinese Han, Uygur, and Kazakh healthy subjects. The measurem
Autor:
Dan Liu, Qiang Zhang, Baoxue Yang, Ya-Xin Lou, Ying-Yuan Lu, Hua Zhang, Zhi-Yuan Zhang, Chuang Lu, Ya-Qing Lou, Guo-Liang Zhang, Pu Li, Xin Wang
Publikováno v:
Biomedical Chromatography. 32:e4157
A specific, sensitive and stable high-performance liquid chromatographic-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantitative determination of methyl 3-amino-6-methoxythieno [2,3-b]quinoline-2-carboxylate (PU-48