Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Ya-Li Lee"'
96
Golf was one of the leisure movements that everyone loved and had glorious history in Taiwan. It was temporarily shutdown by World War II and rebirth while the Japanese subsequently gave up Taiwan after surrendering to the Allies. The history
Golf was one of the leisure movements that everyone loved and had glorious history in Taiwan. It was temporarily shutdown by World War II and rebirth while the Japanese subsequently gave up Taiwan after surrendering to the Allies. The history
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/2ay7ka
94
IL-3, a member of cytokine family, is involved in the cell growth, proliferation, differentiation and apoptosis. IL-3 stimulates its biological effects by binding to a heterodimeric receptor composed of α and β subunits. JAK1 and JAK2 are r
IL-3, a member of cytokine family, is involved in the cell growth, proliferation, differentiation and apoptosis. IL-3 stimulates its biological effects by binding to a heterodimeric receptor composed of α and β subunits. JAK1 and JAK2 are r
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/798y58
Autor:
Amita Patnaik, Erika Hamilton, Yan Xing, Drew W. Rasco, Lon Smith, Ya-Li Lee, Steven Fang, Jiao Wei, Ai-Min Hui
Publikováno v:
Cancers; Volume 14; Issue 20; Pages: 4996
A phase I study evaluated the safety, tolerability, and maximum-tolerated dose (MTD)/recommended phase II dose (RP2D) of FCN-437c, a novel, orally available cyclin-dependent kinase inhibitor (CDK4/6i), in participants with advanced/metastatic solid t
Autor:
Peter W. Lewis, Ya Li Lee, Deyou Zheng, Kyung-Min Noh, Chingwen Yang, Ariane Chapgier, Scott Dewell, Laura A. Banaszynski, Peter J. Scambler, David Garrick, Martin J. Law, Shahin Rafii, Elizabeth A. Boydston, Richard J. Gibbons, Xingyi Guo, Aaron D Goldberg, C. David Allis, Xuan Li, Duancheng Wen, Simon J. Elsaesser, Michael C. Holmes, John M. Greally, Russell Dekelver, Ileana M. Cristea, Jeffrey C. Miller, Sonja C. Stadler, Fyodor D. Urnov, Philip D. Gregory, Douglas R. Higgs
Publikováno v:
Cell. 140:678-691
The incorporation of histone H3 variants has been implicated in the epigenetic memory of cellular state. Using genome editing with zinc finger nucleases to tag endogenous H3.3, we report genome-wide profiles of H3 variants in mammalian embryonic stem
Publikováno v:
Journal of Biochemistry. 147:645-650
Interferon alpha (IFN-alpha) modulates the proliferation of different human tumour cell lines. It has been shown that IFN-alpha induces the growth inhibition of T-cell acute lymphoblastic leukaemia (T-ALL). However, its intracellular signalling mecha
Autor:
Yannick Doyon, W. Michael Ainley, Michael C. Holmes, Robbi Janette Garrison, Beth Rubin-Wilson, Fyodor D. Urnov, Russell Dekelver, Andrew F Worden, Joseph F. Petolino, Ryan C. Blue, Lei Zhang, Erica A. Moehle, Jeremy M. Rock, Charles Q. Cai, Trevor Collingwood, Jeffrey C. Miller, Lisa W. Baker, Edward J. Rebar, Ya-Li Lee, Philip D. Gregory, Farhoud Faraji, Lisa Lynn Schulenberg
Publikováno v:
Plant Molecular Biology. 69:699-709
Targeted transgene integration in plants remains a significant technical challenge for both basic and applied research. Here it is reported that designed zinc finger nucleases (ZFNs) can drive site-directed DNA integration into transgenic and native
Autor:
Jianbin Wang, Christian Beauséjour, Philip D. Gregory, Kenneth Kim, Carl O. Pabo, Jeffrey C. Miller, Adam James Waite, Dmitry Guschin, Nathaniel Wang, Igor Rupniewski, Edward J. Rebar, Ya-Li Lee, Michael C. Holmes
Publikováno v:
Nature Biotechnology. 25:778-785
Genome editing driven by zinc-finger nucleases (ZFNs) yields high gene-modification efficiencies (>10%) by introducing a recombinogenic double-strand break into the targeted gene. The cleavage event is induced using two custom-designed ZFNs that hete
Autor:
Erica A, Moehle, E A, Moehle, Jeremy M, Rock, J M, Rock, Ya-Li, Lee, Y L, Lee, Yann, Jouvenot, Y, Jouvenot, Russell C, DeKelver, R C, Dekelver, Philip D, Gregory, P D, Gregory, Fyodor D, Urnov, F D, Urnov, Michael C, Holmes, M C, Holmes
Publikováno v:
Proceedings of the National Academy of Sciences. 104:3055-3060
Efficient incorporation of novel DNA sequences into a specific site in the genome of living human cells remains a challenge despite its potential utility to genetic medicine, biotechnology, and basic research. We find that a precisely placed double-s
Publikováno v:
Journal of Cellular Biochemistry. 99:1078-1084
The human interleukin-3 receptor (hIL-3R) consists of a unique α subunit (hIL-3Rα) and a common β subunit (βc). Binding of IL-3 to IL-3R activates Janus kinases JAK1 and JAK2. Our previously study showed that JAK2 and JAK1 were constitutively ass
Autor:
Michael C. Holmes, Jeffrey C. Miller, Ya-Li Lee, Jeremy M. Rock, Sheldon Augustus, Philip D. Gregory, Fyodor D. Urnov, Christian Beauséjour, Matthew H. Porteus, Andrew C. Jamieson
Publikováno v:
Nature. 435:646-651
Permanent modification of the human genome in vivo is impractical owing to the low frequency of homologous recombination in human cells, a fact that hampers biomedical research and progress towards safe and effective gene therapy. Here we report a ge