Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Ya-Chu Chang"'
Autor:
Yen-Chun Koh, Ya-Chu Chang, Wei-Sheng Lin, Siu-Yi Leung, Wei-Jen Chen, Shiuan-Huei Wu, Yu-Shan Wei, Chiau-Ling Gung, Ya-Chun Chou, Min-Hsiung Pan
Publikováno v:
ACS Omega, Vol 9, Iss 9, Pp 10253-10266 (2024)
Externí odkaz:
https://doaj.org/article/46668256397647fb8ae5b4ca2fe83075
Autor:
Hung-Hui Wei, Ying-Chieh Lai, Gigin Lin, Cheng-Wei Lin, Ya-Chu Chang, John Wen-Cheng Chang, Miaw-Jene Liou, I-Wen Chen
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background Immune checkpoint inhibitors (ICI) are promising treatment options for various cancers. However, their use is associated with immune-related adverse events (irAEs), including ICI-induced diabetes mellitus (ICI-DM). This study aime
Externí odkaz:
https://doaj.org/article/0c74cd8ef065457ab3824351707e78d0
Autor:
Kevin Lin, Ya-Chu Chang, Maximilian Billmann, Henry N. Ward, Khoi Le, Arshia Z. Hassan, Urvi Bhojoo, Katherine Chan, Michael Costanzo, Jason Moffat, Charles Boone, Anja-Katrin Bielinsky, Chad L. Myers
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Current approaches to define chemical-genetic interactions (CGIs) in human cell lines are resource-intensive. We designed a scalable chemical-genetic screening platform by generating a DNA damage response (DDR)-focused custom sgRNA library t
Externí odkaz:
https://doaj.org/article/3b9ce5f7b8554685b2e0afb2fc4f3cce
Autor:
Wendy Leung, Ryan M. Baxley, Emma Traband, Ya-Chu Chang, Colette B. Rogers, Liangjun Wang, Wesley Durrett, Kendall S. Bromley, Lidia Fiedorowicz, Tanay Thakar, Anika Tella, Alexandra Sobeck, Eric A. Hendrickson, George-Lucian Moldovan, Naoko Shima, Anja-Katrin Bielinsky
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113523- (2023)
Summary: Ubiquitination of proliferating cell nuclear antigen (PCNA) at lysine 164 (K164) activates DNA damage tolerance pathways. Currently, we lack a comprehensive understanding of how PCNA K164 ubiquitination promotes genome stability. To evaluate
Externí odkaz:
https://doaj.org/article/0ee3d1a6203142ac8d65a9bb37a15e23
Autor:
Ya-Chu Chang, Kevin Lin, Ryan M. Baxley, Wesley Durrett, Liangjun Wang, Olivera Stojkova, Maximilian Billmann, Henry Ward, Chad L. Myers, Anja-Katrin Bielinsky
Publikováno v:
Open Biology, Vol 13, Iss 8 (2023)
DNA replication requires precise regulation achieved through post-translational modifications, including ubiquitination and SUMOylation. These modifications are linked by the SUMO-targeted E3 ubiquitin ligases (STUbLs). Ring finger protein 4 (RNF4),
Externí odkaz:
https://doaj.org/article/fc25571c38be441b9df006b8d49f3bfe
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Transactive response DNA binding protein-43 (TDP-43) is known to mediate neurodegeneration associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The exact mechanism by which TDP-43 exerts toxicity in the br
Externí odkaz:
https://doaj.org/article/2dd5abe025f24522a5522a7f507980b3
Autor:
Kevin Lin, Ya-Chu Chang, Ezequiel Marron Fernandez de Velasco, Kevin Wickman, Chad L. Myers, Anja-Katrin Bielinsky
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101675- (2022)
Summary: Pooled lentiviral CRISPR-Cas9 screens are utilized for assessing the differential sensitivity or resistance of many single-gene knockouts to a compound. Here, we present a scalable approach for high-throughput compound screening by utilizing
Externí odkaz:
https://doaj.org/article/954cde00cbfd4802acf251d0cbe0cfb8
Autor:
Ya-Chu Chang, Yu-Xiang Peng, Bo-Hua Yu, Henry C. Chang, Pei-Shin Liang, Ting-Yi Huang, Chao-Jie Shih, Li-An Chu, Tzu-Kang Sang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Cells maintain a constant cytoplasm to nucleus volume ratio, although the role of DNA damage is not well explored. Here, the authors use Drosophila to connect TER94, the fly homolog of VCP, to disruption of DNA damage repair, leading to ubiquitinated
Externí odkaz:
https://doaj.org/article/a98e31b8568b4570a73299717fbf8dd4
Autor:
Ya-Chu Chang
Publikováno v:
Advances in Mechanical Engineering, Vol 12 (2020)
The field of electronic device applications is becoming more and more extensive. With the development of science and technology and the improvement of the integration of electronic components, local heating is becoming more and more serious. If heat
Externí odkaz:
https://doaj.org/article/1296e88dd0f24dbf8bb63696ed09da5a
Autor:
Shi-Rong Hong, Cuei-Ling Wang, Yao-Shen Huang, Yu-Chen Chang, Ya-Chu Chang, Ganesh V. Pusapati, Chun-Yu Lin, Ning Hsu, Hsiao-Chi Cheng, Yueh-Chen Chiang, Wei-En Huang, Nathan C. Shaner, Rajat Rohatgi, Takanari Inoue, Yu-Chun Lin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Tubulin post-translational modifications (PTMs) occur spatiotemporally throughout cells, therefore assessing the physiological roles in specific subcellular compartments has been challenging. Here the authors develop a method to rapidly deplete tubul
Externí odkaz:
https://doaj.org/article/c1e3bf213f4f48708f15f622d8dd14fd