Zobrazeno 1 - 10
of 262
pro vyhledávání: '"Ya-Ching Shen"'
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Mutated proto-oncogene BRAF is a bona fide therapeutic target for melanomas. Regrettably, melanoma acquires resistance to BRAF inhibitors, e.g., vemurafenib (PLX4032) casting doubt on this promising melanoma targeted therapy. In this study, we explor
Externí odkaz:
https://doaj.org/article/ad3e74aa075d4c0a8d4955205aa6a3d9
Autor:
Shih-Sheng Wang, Yuan-Bin Cheng, Yu-Chi Lin, Chia-Ching Liaw, Jiun-Yang Chang, Yao-Haur Kuo, Ya-Ching Shen
Publikováno v:
Marine Drugs, Vol 13, Iss 9, Pp 5796-5814 (2015)
Two new nitrogen-containing verticillene diterpenoids, cespilamides A and B (1 and 2), three new nitrogen-containing sesquiterpenoids, cespilamides C–E (3–5), and five new norverticillene and verticillene diterpenoids, cespitaenins A–E (6–10)
Externí odkaz:
https://doaj.org/article/7db1c64cfba8493d98b624def5551fa1
Autor:
Chia-Ching Liaw, Yuan-Bin Cheng, Yun-Sheng Lin, Yao-Haur Kuo, Tsong-Long Hwang, Ya-Ching Shen
Publikováno v:
Marine Drugs, Vol 12, Iss 8, Pp 4677-4692 (2014)
Ten new briarane diterpenoids, briaviolides A–J (1–10), together with six known briaranes, solenolides A and D, excavatolide A, briaexcavatolide I, 4β-acetoxy-9-deacetystylatulide lactone and 9-deacetylstylatulide lactone, were isolated from the
Externí odkaz:
https://doaj.org/article/2bf336cd7dc44d74965f2fd81e356328
Publikováno v:
Marine Drugs, Vol 12, Iss 6, Pp 3477-3486 (2014)
Two novel diterpenoids, cespitulones A (1) and B (2), were isolated from extracts of the soft coral Cespitularia taeniata. Both compounds possess an unprecedented bicyclo [10.3.1] ring system with C-C bond connections between C-10 and C-20, and betwe
Externí odkaz:
https://doaj.org/article/a946449890784b018fd7f1d21b79b91c
Autor:
Chang-Hung Chou, Yao-Haur Kuo, Michael Y. Chiang, I-Wen Lo, Chia-Ching Liaw, Yuan-Bin Cheng, Yu-Chi Lin, Ya-Ching Shen
Publikováno v:
Molecules, Vol 18, Iss 6, Pp 6573-6583 (2013)
Three novel C19 homolignans, taiwankadsurins D (1), E (2) and F (4), and two new C18 lignans kadsuphilins N (3) and O (5) were isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The structures of compounds 1–5 were
Externí odkaz:
https://doaj.org/article/3a44a45ae18e4807be957d2d3a2286a7
Autor:
Tsong-Long Hwang, Yun-Sheng Lin, Chung-Hsiung Chen, Yu-Chi Lin, Chia-Ching Liaw, Ya-Ching Shen
Publikováno v:
Marine Drugs, Vol 11, Iss 6, Pp 2042-2053 (2013)
Four new 8-hydroxybriarane diterpenoids, frajunolides P–S (1–4), together with umbraculolide A, juncenolide C, junceellonoid A and juncin R, were isolated from the acetone extract of the gorgonian Junceella fragilis, collected from the southeast
Externí odkaz:
https://doaj.org/article/e42d745d56c94ed6975b4c5fa3ebedc6
Publikováno v:
Marine Drugs, Vol 10, Iss 6, Pp 1321-1330 (2012)
Chemical investigation of Junceella juncea has resulted in the isolation of three new briaranes designated juncenolides M–O (1–3). The structures of these compounds were determined by spectroscopic analysis including 2D-NMR (COSY, HMBC and NOESY)
Externí odkaz:
https://doaj.org/article/81119f2f7fe3450f85c0914e55f6e0d8
Publikováno v:
Marine Drugs, Vol 9, Iss 9, Pp 1477-1486 (2011)
Four new 8-hydroxybriarane diterpenoids, frajunolides L–O (1–4), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 1–4 were elucidated based on spectroscopic analysis, especially 2D NMR (1H-1H COSY, HSQC
Externí odkaz:
https://doaj.org/article/40fb182891df4f55a7f5ef51f2de1271
Autor:
Ji-Wang Chern, Sheau Farn Yeh, Lan-Chun Tu, Chia-Ching Liaw, Yao Haur Kuo, Chun-Ling Lin, Yao-To Chang, Ya-Ching Shen
Publikováno v:
Marine Drugs, Vol 9, Iss 2, Pp 256-277 (2011)
A series of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-b-carboline analogs have been synthesized and evaluated for antitumor activity against human tumor cells including KB, DLD, NCI-H661, Hepa, and HepG2/A2 cell lines. A
Externí odkaz:
https://doaj.org/article/019d251a64654ab6b83e93f77d1db8b7
Autor:
Ching-Jie Lin, I-Wen Lo, Yu-Chi Lin, Shun-Ying Chen, Ching-Te Chien, Yao-Haur Kuo, Tsong-Long Hwang, Shorong-Shii Liou, Ya-Ching Shen
Publikováno v:
Molecules, Vol 21, Iss 9, p 1167 (2016)
Phytochemical investigation of the acetone extract from the roots of Aphanamixis polystachya resulted in isolation of four new tetranortriterpenes (1–4) in addition to one protolimonoid (methyl-1ξ,7R-diacetoxy-23R,25-dihydroxy-20S,24R-21,24-epoxy-
Externí odkaz:
https://doaj.org/article/327f2ea5268042b6a53dc8a96a3675a2