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SET8, a novel regulator to ameliorate vascular calcification via activating PI3K/Akt mediated anti-apoptotic effects

Autor: Jing Jing Jin, Wei Zhou, Hui Ran Zhang, Lei He, Mei Juan Cheng, Sheng Lei Zhang, Jin Sheng Xu, Ya Ling Bai

Publikováno v: Biochemistry and cell biology = Biochimie et biologie cellulaire. 100(2)

Previous studies have showed that the apoptosis of vascular smooth muscle cells (VSMCs) underlies the mechanism of pathological calcifications in patients with chronic kidney disease (CKD). SET domain-containing protein 8 (SET8), as an efficient prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf0ffeb80f39842c925f1140fccaf93
https://pubmed.ncbi.nlm.nih.gov/34846946

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High ambient glucose levels modulates the production of MMP-9 and alpha5(IV) collagen by cultured podocytes

Autor: Senyan Liu, Yongqiang Li, Haichang Huang, Ya-ling Bai, Jingzi Li, Lizhu Wang, Haiyan Wang

Publikováno v: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 17(1-2)

Recent evidences have demonstrated an important role for glomerular visceral epithelial cell (podocyte) in the development and progression of diabetic nephropathy. We investigated the high-glucose (HG)-triggered signaling pathway and its role in matr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4b86f540daac6c68d80cd89fdfd8ba
https://pubmed.ncbi.nlm.nih.gov/16543722

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[High glucose regulates the production of MMP-9 in podocyte through ERK1/2 signal pathway]

Autor: Ya-ling, Bai, Hai-chang, Huang, Jing-zi, Li, Yu-yong, Zhao, Hai-yan, Wang

Publikováno v: Zhonghua yi xue za zhi. 85(21)

To assess the effect of high glucose on the production of gelatinase and collagen alpha (IV) protein in podocytes and its possible signal pathway.Mouse podocytes of an immortalized cell line were cultured and divided into 3 groups: NG group, treated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03b1f2d54c78dcbe3451c1f9613ba603
https://pubmed.ncbi.nlm.nih.gov/16061020

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