Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ya Jen Chiu"'
Autor:
Te-Hsien Lin, Ya-Jen Chiu, Chih-Hsin Lin, Yi-Ru Chen, Wenwei Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Chiung-Mei Chen, Guey-Jen Lee-Chen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
BackgroundIn Parkinson's disease (PD) brains, microglia are activated to release inflammatory factors to induce the production of reactive oxygen species (ROS) in neuron, and vice versa. Moreover, neuroinflammation and its synergistic interaction wit
Externí odkaz:
https://doaj.org/article/d2ad577bd4044808aafb1de80cb17078
Autor:
Zheng-Kui Weng, Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Chih-Hsin Lin, Pei-Hsuan Tseng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen, Chiung-Mei Chen
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 219 (2023)
Misfolded aggregation of the hyperphosphorylated microtubule binding protein Tau in the brain is a pathological hallmark of Alzheimer’s disease (AD). Tau aggregation downregulates brain-derived neurotrophic factor (BDNF)/tropomycin receptor kinase
Externí odkaz:
https://doaj.org/article/9934b3950a89424da630b45ecdf060e8
Autor:
Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Pei-Ning Yang, Yen-Shi Lo, Yu-Chieh Chen, Chiung-Mei Chen, Yih-Ru Wu, Ching-Fa Yao, Kuo-Hsuan Chang, Guey-Jen Lee-Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2642 (2023)
Neuroinflammation and oxidative stress have been emerging as important pathways contributing to Parkinson’s disease (PD) pathogenesis. In PD brains, the activated microglia release inflammatory factors such as interleukin (IL)-β, IL-6, tumor necro
Externí odkaz:
https://doaj.org/article/3a8fda2e57474564a02e5f9ac62e56be
Autor:
Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Zheng-Kui Weng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen, Chiung-Mei Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 12734 (2022)
Hyperphosphorylation and aggregation of the microtubule binding protein tau is a neuropathological hallmark of Alzheimer’s disease/tauopathies. Tau neurotoxicity provokes alterations in brain-derived neurotrophic factor (BDNF)/tropomycin receptor k
Externí odkaz:
https://doaj.org/article/fa633c9f139f4008a6d098064eb5fb08
Autor:
Ya-Jen Chiu, Yu-Shan Teng, Chiung-Mei Chen, Ying-Chieh Sun, Hsiu Mei Hsieh-Li, Kuo-Hsuan Chang, Guey-Jen Lee-Chen
Publikováno v:
Biomolecules & Therapeutics. 31:285-297
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cc14cf41526fe1a53aac8b96e9b87e9
https://doi.org/10.4062/biomolther.2022.136
https://doi.org/10.4062/biomolther.2022.136
Autor:
Ching-Chia Huang, Kuo-Hsuan Chang, Ya-Jen Chiu, Yi-Ru Chen, Tsai-Hui Lung, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Ying-Chieh Sun, Chiung-Mei Chen, Wenwei Lin, Guey-Jen Lee-Chen
Publikováno v:
Cells, Vol 10, Iss 11, p 3095 (2021)
Alzheimer’s disease (AD) is a common neurodegenerative disease presenting with progressive memory and cognitive impairments. One of the pathogenic mechanisms of AD is attributed to the aggregation of misfolded amyloid β (Aβ), which induces neurot
Externí odkaz:
https://doaj.org/article/55f12e9aea6649f9b7d98415a9df3644
Autor:
Ya-Jen Chiu, Te-Hsien Lin, Kuo-Hsuan Chang, Wenwei Lin, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Chiung-Mei Chen, Ying-Chieh Sun, Guey-Jen Lee-Chen
Publikováno v:
Aging. 14(18)
Decreased BDNF and impaired TRKB signaling contribute to neurodegeneration in Alzheimer's disease (AD). We have shown previously that coumarin derivative LM-031 enhanced CREB/BDNF/BCL2 pathway. In this study we explored if LM-031 analogs LMDS-1 to -4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b2d49adbac1a8e63d1c9edd06edde4
https://pubmed.ncbi.nlm.nih.gov/36170028
https://pubmed.ncbi.nlm.nih.gov/36170028
Autor:
Chiung Mei Chen, Yi Ru Chen, Hsiu Mei Hsieh-Li, Ming Tsan Su, Ching Chia Huang, Ying Chieh Sun, Kuo-Hsuan Chang, Guey Jen Lee-Chen, Ya Jen Chiu, Tsai Hui Lung, Wenwei Lin
Publikováno v:
Cells
Cells, Vol 10, Iss 3095, p 3095 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 3095, p 3095 (2021)
Volume 10
Issue 11
Alzheimer’s disease (AD) is a common neurodegenerative disease presenting with progressive memory and cognitive impairments. One of the pathogenic mechanisms of AD is attributed to the aggregation of misfolded amyloid β (Aβ), which induces neurot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db79c67896b5992edb9855ee5432a7ce
https://pubmed.ncbi.nlm.nih.gov/34831318
https://pubmed.ncbi.nlm.nih.gov/34831318
Autor:
Guey Jen Lee-Chen, Ying Chieh Sun, Yu Hsuan Hsieh, Ya Jen Chiu, Te Hsien Lin, Chiung Mei Chen, Kuo-Hsuan Chang, Guan Chiun Lee, Hsiu Mei Hsieh-Li
Publikováno v:
Neurochemistry International. 125:175-186
The pathogenesis of Alzheimer's disease (AD) is involved in the aggregation of misfolded amyloid β (Aβ), which upregulates the activity of acetylcholinesterase (AChE), increases the production of reactive oxygen species (ROS), enhances neuroinflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d16e478a0efff8236768990e6df243
https://doi.org/10.1016/j.neuint.2019.01.021
https://doi.org/10.1016/j.neuint.2019.01.021
Autor:
Ching Fa Yao, Hei Jen Huang, Jia Lu Wu, Chih Hsin Lin, Hsiu Mei Hsieh-Li, Chen Hsiang Huang, Yih Ru Wu, Kuo-Hsuan Chang, Chiung Mei Chen, Guey Jen Lee-Chen, Wen Chuin Hsu, Ya Jen Chiu, Chia Wei Lin, Yi-Chun Chen, Yen Shi Lo
Publikováno v:
Journal of Alzheimer's Disease. 67:737-756
Alzheimer's disease (AD), associated with abnormal accumulation of amyloid-β (Aβ), is the most common cause of dementia among older people. A few studies have identified substantial AD biomarkers in blood but their results were inconsistent. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98068d01ec3bd4a229f9ccc85f0e29e
https://doi.org/10.3233/jad-180643
https://doi.org/10.3233/jad-180643