Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ya‐Kai Xie"'
Autor:
Heng Zhang, Jia-Jia Lin, Ya-Kai Xie, Xiu-Zu Song, Jia-Yi Sun, Bei-Lei Zhang, Yun-Kun Qi, Zhen-Zhong Xu, Fan Yang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
TRPV1 as a drug target suffers from side effects of hypothermia. Here, authors engineer a peptide, sRhTx, as a positive allosteric modulator of TRPV1 channel. It potentiates the activity of TRPV1 to reversibly ablate pain-sensing nerve terminals for
Externí odkaz:
https://doaj.org/article/4f6d4493ac1f4d9c9aa5df9ee8c2731d
Autor:
Aerziguli Aierken, Ya‐Kai Xie, Wenqi Dong, Abuliken Apaer, Jia‐Jia Lin, Zihan Zhao, Shilong Yang, Zhen‐Zhong Xu, Fan Yang
Publikováno v:
Advanced Science, Vol 8, Iss 22, Pp n/a-n/a (2021)
Abstract Platinum‐based compounds in chemotherapy such as oxaliplatin often induce peripheral neuropathy and neuropathic pain such as cold allodynia in patients. Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is a nociceptor critical
Externí odkaz:
https://doaj.org/article/6708c24e19d8497b9799498ae01517f0
Publikováno v:
Neurosci Bull
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7602444b17735e07801127c5976c42
https://doi.org/10.1007/s12264-021-00714-8
https://doi.org/10.1007/s12264-021-00714-8
GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation
Autor:
Ya-Kai Xie, Hao Luo, Shan-Xin Zhang, Xiao-Ying Chen, Ran Guo, Xiao-Yun Qiu, Shuai Liu, Hui Wu, Wen-Bo Chen, Xing-Hua Zhen, Qiang Ma, Jin-Lan Tian, Shun Li, Xinzhong Chen, Qingjian Han, Shumin Duan, Chengyong Shen, Fan Yang, Zhen-Zhong Xu
Publikováno v:
Science Translational Medicine. 14
Diabetic neuropathic pain (DNP) is a common and devastating complication in patients with diabetes. The mechanisms mediating DNP are not completely elucidated, and effective treatments are lacking. A-fiber sensory neurons have been shown to mediate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f77aab2d510b57c4c5915f46c837f5
https://doi.org/10.1126/scitranslmed.abh2557
https://doi.org/10.1126/scitranslmed.abh2557
Autor:
Heng Zhang, Jia-Jia Lin, Ya-Kai Xie, Xiu-Zu Song, Jia-Yi Sun, Bei-Lei Zhang, Yun-Kun Qi, Zhen-Zhong Xu, Fan Yang
Publikováno v:
Nature communications. 14(1)
Transient receptor potential vanilloid 1 (TRPV1) ion channel is a classic analgesic target, but antagonists of TRPV1 failed in clinical trials due to their side effects like hyperthermia. Here we rationally engineer a peptide s-RhTx as a positive all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4474803aa9cf3ac3aaacaf1753ea74bd
https://pubmed.ncbi.nlm.nih.gov/36596769
https://pubmed.ncbi.nlm.nih.gov/36596769
Publikováno v:
Fish & Shellfish Immunology. 86:429-435
As an important disulfide reductase of the intracellular antioxidant system, Thioredoxin (Trx) plays an important role in maintaining oxidative stress balance and protecting cells from oxidative damage. In recent years, there is increasing evidence t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bba7b70ca4ea4e11c0ee1770b35e49
https://doi.org/10.1016/j.fsi.2018.11.064
https://doi.org/10.1016/j.fsi.2018.11.064
Publikováno v:
Brain : a journal of neurology. 144(11)
Neuropathic pain is a major health problem that affects up to 7–10% of the population worldwide. Currently, neuropathic pain is difficult to treat because of its elusive mechanisms. Here we report that orphan G protein-coupled receptor 151 (GPR151)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb418c0e3f9049905ceed5ac59639c9
https://pubmed.ncbi.nlm.nih.gov/34244727
https://pubmed.ncbi.nlm.nih.gov/34244727
Autor:
Jun Wang, Jie Li, Ya-Kai Xie, Shumin Duan, Zhi-Ying Wu, Yulong Li, Tian-Le Xu, Zhen-Zhong Xu, Ya-Lan Wen, Han Xu, Qian Yang
Publikováno v:
Proc Natl Acad Sci U S A
Sociability is fundamental for our daily life and is compromised in major neuropsychiatric disorders. However, the neuronal circuit mechanisms underlying prosocial behavior are still elusive. Here we identify a causal role of the basal forebrain (BF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d344148219fc08cde17f577ee56c093
https://doi.org/10.1073/pnas.2019295118
https://doi.org/10.1073/pnas.2019295118
The mechanisms of pain induction by inflammation have been extensively studied. However, the mechanisms of pain resolution are not fully understood. Here, we report that GPR37, expressed by macrophages (MΦs) but not microglia, contributes to the res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b167160aa618651a07ce1e0d59c449c8
https://europepmc.org/articles/PMC6063480/
https://europepmc.org/articles/PMC6063480/
Publikováno v:
Fish & Shellfish Immunology. 47:147-156
β-Catenin is a multifunctional protein that is involved in many physiological processes, including development, cell proliferation, cell migration, and apoptosis. However, the function of β-Catenin in crustacean is unknown. In this study, the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d183fe279731278be4607e976bb42e
https://doi.org/10.1016/j.fsi.2015.08.030
https://doi.org/10.1016/j.fsi.2015.08.030