A microfluidic device enabling drug resistance analysis of leukemia cells via coupled dielectrophoretic detection and impedimetric counting

Autor: Yağmur Demircan Yalçın, Taylan Berkin Töral, Sertan Sukas, Ender Yıldırım, Özge Zorlu, Ufuk Gündüz, Haluk Külah

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract We report the development of a lab-on-a-chip system, that facilitates coupled dielectrophoretic detection (DEP-D) and impedimetric counting (IM-C), for investigating drug resistance in K562 and CCRF-CEM leukemia cells without (immuno) labeli

Externí odkaz: https://doaj.org/article/4330e938ceb241da919d8e16d7e7f523

A Novel Microfluidic Method Utilizing a Hydrofoil Structure to Improve Circulating Tumor Cell Enrichment: Design and Analytical Validation

Autor: Gürhan Özkayar, Ege Mutlu, Şebnem Şahin, Yağmur Demircan Yalçın, Taylan Töral, Haluk Külah, Ender Yildirim, Özge Zorlu, Ebru Özgür

Publikováno v: Micromachines, Vol 11, Iss 11, p 981 (2020)

Being one of the major pillars of liquid biopsy, isolation and characterization of circulating tumor cells (CTCs) during cancer management provides critical information on the evolution of cancer and has great potential to increase the success of the

Externí odkaz: https://doaj.org/article/b99e7d2149d841f8b466c53015f1f625

Long-term brain-on-chip: Multielectrode array recordings in 3D neural cell cultures

Autor: Yağmur Demircan Yalçın, Regina Luttge, Jean-Philippe Frimat, Alex J. Bastiaens

Publikováno v: Journal of Vacuum Science and Technology, B, 39(6):064004. AVS Science and Technology Society
JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B, 39(6). A V S AMER INST PHYSICS

This study presents sensing of network bursts in a three-dimensional (3D) cell culture system consisting of a microbioreactor and a multielectrode array (MEA), i.e., brain-on-chip, to interpret neural network dynamics in a label-free manner. While ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed0cc213ee3746fdae6611decacc696
https://research.tue.nl/nl/publications/5a69e4a2-d7e2-4dcc-bfef-c6ba6e367366

Electrical monitoring approaches in 3-dimensional cell culture systems: Toward label-free, high spatiotemporal resolution, and high-content data collection in vitro

Autor: Regina Luttge, Yağmur Demircan Yalçın

Publikováno v: Organs-on-a-Chip

3-dimensional (3D) cell cultures better mimic natural environment of cells than 2-dimensional (2D) cell cultures to obtain in vivo like inter and intracellular responses. However, third dimension brings complexity to cell culture. Therefore, high-res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3e7ed003d361ca176b6184bce28d79

Examination of the dielectrophoretic spectra of MCF7 breast cancer cells and leukocytes

Autor: Haluk Kulah, Zeynep Çağlayan, Yağmur Demircan Yalçın

Publikováno v: Electrophoresis5 References. 41(5-6)

The detection of circulating tumor cells (CTCs) in blood is crucial to assess metastatic progression and to guide therapy. Dielectrophoresis (DEP) is a powerful cell surface marker-free method that allows intrinsic dielectric properties of suspended

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be24dcd4ecd91afd8acd7c967e7812a
https://pubmed.ncbi.nlm.nih.gov/31925804