Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Yaíma L Lightfoot"'
Autor:
Yaíma L Lightfoot, Tao Yang, Bikash Sahay, Mojgan Zadeh, Sam X Cheng, Gary P Wang, Jennifer L Owen, Mansour Mohamadzadeh
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100532 (2014)
Gastrointestinal (GI) anthrax results from the ingestion of Bacillus anthracis. Herein, we investigated the pathogenesis of GI anthrax in animals orally infected with toxigenic non-encapsulated B. anthracis Sterne strain (pXO1+ pXO2-) spores that res
Externí odkaz:
https://doaj.org/article/23e5c5c2dc494cce92dbcb44ff5e8067
Autor:
Mahesh Kathania, Mojgan Zadeh, Yaíma L Lightfoot, Robert M Roman, Bikash Sahay, Jeffrey R Abbott, Mansour Mohamadzadeh
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55143 (2013)
Currently, sufficient data exist to support the use of lactobacilli as candidates for the development of new oral targeted vaccines. To this end, we have previously shown that Lactobacillus gasseri expressing the protective antigen (PA) component of
Externí odkaz:
https://doaj.org/article/c5d36c0cea254bee907826aef2a7410a
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20617 (2011)
Mitochondria are indispensable in the life and death of many types of eukaryotic cells. In pancreatic beta cells, mitochondria play an essential role in the secretion of insulin, a hormone that regulates blood glucose levels. Unregulated blood glucos
Externí odkaz:
https://doaj.org/article/008c6c47a54b494f931f4d955c9736c0
Autor:
Yaíma L. Lightfoot, Saeko Nakajima, Verena M. Link, Samira Tamoutounour, Oliver J. Harrison, Christopher K. E. Bleck, Mariana J. Kaplan, E. Merrill, Jonathan L. Linehan, Margery G. Smelkinson, Seong-Ji Han, Yasmine Belkaid, C. Hurabielle, Nicolas Bouladoux, Nickie L Seto, Michail S. Lionakis
Publikováno v:
Proc Natl Acad Sci U S A
Under steady-state conditions, the immune system is poised to sense and respond to the microbiota. As such, immunity to the microbiota, including T cell responses, is expected to precede any inflammatory trigger. How this pool of preformed microbiota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebac6fa576b6f186dd0e7130d2a41faf
https://doi.org/10.1073/pnas.2003022117
https://doi.org/10.1073/pnas.2003022117
Autor:
Zerai Manna, Richard M. Siegel, Yaíma L. Lightfoot, Pragnesh Mistry, Kerry A. Casey, Carolyne K. Smith, Richard N. Hanna, Saifur Rahman, Divya Sagar, Mariana J. Kaplan, Roland Kolbeck, Sarfaraz Hasni, Miguel A. Sanjuan
Publikováno v:
Annals of the Rheumatic Diseases
ObjectivesThe presence of proinflammatory low-density granulocytes (LDG) has been demonstrated in autoimmune and infectious diseases. Recently, regulatory neutrophilic polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) were identified in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d7a98f6b523b1767b6d5a1b104bf1c
https://doi.org/10.1136/annrheumdis-2018-214620
https://doi.org/10.1136/annrheumdis-2018-214620
Autor:
Luz P. Blanco, Victoria Hoffmann, Carmelo Carmona-Rivera, Peter S.T. Yuen, Hege Lynum Pedersen, Nickie L Seto, Yaíma L. Lightfoot, Xinghao Wang, Zu Xi Yu, Mariana J. Kaplan
Publikováno v:
Arthritis Rheumatol
OBJECTIVE A role for mitochondrial dysfunction has been proposed in the immune dysregulation and organ damage characteristic of systemic lupus erythematosus (SLE). Idebenone is a coenzyme Q10 synthetic quinone analog and an antioxidant that has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88412c57844236ef9157d7e0769a9766
https://europepmc.org/articles/PMC7050361/
https://europepmc.org/articles/PMC7050361/
Autor:
Mariana J. Kaplan, Yaíma L. Lightfoot
Publikováno v:
Current Opinion in Rheumatology. 29:65-70
PURPOSE OF REVIEW A breakdown of immune tolerance to self-antigens in a genetically predisposing background, precipitated by environmental triggers, contributes to the development of systemic autoimmune diseases. Renewed interest in the immunomodulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a931d95967acf73cb0238d9d419bbaa8
https://doi.org/10.1097/bor.0000000000000357
https://doi.org/10.1097/bor.0000000000000357
Autor:
Yudong Liu, Mariana J. Kaplan, Victoria Hoffman, Luz P. Blanco, Nickie L Seto, Hege Lynum Pedersen, Yaíma L. Lightfoot, Peter S.T. Yuen, Carmelo Carmona-Rivera
Publikováno v:
Abstracts.
Background Immune dysregulation and organ damage are characteristic of systemic lupus erythematosus (SLE). We previously reported that mitochondrial reactive oxygen species (ROS) and the release of oxidized mitochondrial DNA (mtDNA) may be involved i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08a23c66d312ce24fb57c85566cbbb0
https://doi.org/10.1136/lupus-2019-lsm.23
https://doi.org/10.1136/lupus-2019-lsm.23
Autor:
Rishi R. Goel, Paul R. Thompson, Yaíma L. Lightfoot, Hong-Wei Sun, Yudong Liu, Scott A. Coonrod, Erica Moore, Pragnesh Mistry, Santanu Mondal, Padmavathy Nandha Premnath, Nickie L Seto, Liam J. O’Neil, Kan Jiang, Stefania Dell'Orso, Carmelo Carmona-Rivera, Katherine Gribbons, Victoria Hoffmann, Mariana J. Kaplan
The peptidylarginine deiminases PAD2 and PAD4 are implicated in the pathogenesis of several autoimmune diseases. PAD4 may be pathogenic in systemic lupus erythematosus (SLE) through its role in neutrophil extracellular trap (NET) formation that promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d95abeb0d2f62d76402a5728bf77136
https://europepmc.org/articles/PMC6328098/
https://europepmc.org/articles/PMC6328098/
Autor:
Andrea Lin, Michael J. Haller, Amanda L. Posgai, Clayton E. Mathews, Xia Li, Mark A. Atkinson, Song Xue, Yaíma L. Lightfoot, Clive Wasserfall, Desmond A. Schatz
Publikováno v:
Diabetes
Most natural history models for type 1 diabetes (T1D) propose that overt hyperglycemia results after a progressive loss of insulin-secreting β-cell mass and/or function. To experimentally address this concept, we prospectively determined morning blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25da41eb6da08a6a5f0f846f8da2eb5
https://doi.org/10.2337/db15-0449
https://doi.org/10.2337/db15-0449