Zobrazeno 1 - 10
of 951
pro vyhledávání: '"YY Chang"'
Publikováno v:
ACS Sensors. 4:1190-1196
Small molecule-based fluorescent probes offer great opportunities for specifically tracking proteins in living systems with minimal perturbation on the protein function and localization. Herein, we report a small green fluorescent probe (Ni2+-NTA-AF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6277f2c149d0fdcb6c5ec6cacc03181
https://doi.org/10.1021/acssensors.8b01128
https://doi.org/10.1021/acssensors.8b01128
Autor:
Quan Quan, Hongyan Li, Yau Tsz Lai, Xinming Yang, Wei Xia, Yuchuan Wang, Ya Yang, Ivan K. Chu, Junwen Wang, Hongzhe Sun, Ligang Hu, Zhifang Chai, YY Chang, Feng Xu
Publikováno v:
Chemical Science. 8:4626-4633
Bismuth drugs, despite being clinically used for decades, surprisingly remain in use and effective for the treatment of Helicobacter pylori infection, even for resistant strains when co-administrated with antibiotics. However, the molecular mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e2efc2215acb09b15d1e9bc864980f
https://doi.org/10.1039/c7sc00766c
https://doi.org/10.1039/c7sc00766c
Autor:
YY Chang, Chengmin Qian, Julian A. Tanner, Hongyan Li, Yau-Tsz Lai, Kwan-Ming Ng, Ya Yang, Mee-Len Chye, Ligang Hu, Hongzhe Sun, Zhi-Yan Du, Ailun Chao
Publikováno v:
ResearcherID
Small molecule-based fluorescent probes have been used for realtime visualization of live cells and tracking of various cellular events with minimal perturbation on the cells being investigated. Given the wide utility of the (histidine)6-Ni2+-nitrilo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c004a1fbeae21e478b5220a0a7d037a
https://doi.org/10.1073/pnas.1419598112
https://doi.org/10.1073/pnas.1419598112
Autor:
Hongzhe Sun, Runming Wang, Patrick C. Y. Woo, YY Chang, Mohamad Koohi-Moghadam, Xinming Yang, Hongyan Li, Junwen Wang
Publikováno v:
PLoS Biology, Vol 16, Iss 1, p e2003887 (2018)
PLoS Biology
PLoS Biology
Urease as a potential target of antimicrobial drugs has received considerable attention given its versatile roles in microbial infection. Development of effective urease inhibitors, however, is a significant challenge due to the deeply buried active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6b49d9b40affee11970c661259607e
https://doaj.org/article/6cdf97416bcf441590d153812d992872
https://doaj.org/article/6cdf97416bcf441590d153812d992872
Publikováno v:
Metallomics. 7:1399-1406
On-line coupling of gel electrophoresis with inductively coupled plasma-mass spectrometry (GE-ICP-MS) offers a strategy to monitor intracellular metals and their associated proteins simultaneously. Herein, we examine the feasibility of the GE-ICP-MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034770a4fb1e8f105cab65139ef7a40d
https://doi.org/10.1039/c5mt00054h
https://doi.org/10.1039/c5mt00054h
Publikováno v:
Journal of Inorganic Biochemistry. 142:8-14
Hpn-like (Hpnl) is a unique histidine- and glutamine-rich protein found only in Helicobacter pylori and plays a role on nickel homeostasis. We constructed the fluorescent sensor proteins CY Hpnl and CY Hpnl_1-48 (C-terminal glutamine-rich region trun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01715dddde109ac694418a20d513e729
https://doi.org/10.1016/j.jinorgbio.2014.09.010
https://doi.org/10.1016/j.jinorgbio.2014.09.010
Publikováno v:
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 22(5)
Bismuth drugs have been used clinically to treat infections from Helicobacter pylori, a pathogen that is strongly related to gastrointestinal diseases even stomach cancer. Despite extensive studies, the mechanisms of action of bismuth drugs are not f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0aa0dbe7b21681befacbc0e9198cf72
https://pubmed.ncbi.nlm.nih.gov/28361362
https://pubmed.ncbi.nlm.nih.gov/28361362
Although metalloproteins or metal-binding proteins have been ascertained to be associated with human health and diseases, the roles of metalloproteins in disease processes are not fully understood and require further comprehensive exploration. Immobi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff73e63014c89003b86a079eded38e75
https://doi.org/10.1016/b978-0-12-803814-7.00009-5
https://doi.org/10.1016/b978-0-12-803814-7.00009-5
Autor:
Hongyan Li, Ligang Hu, YY Chang, Yau Tsz Lai, Ya Yang, Hongzhe Sun, Tianfan Cheng, Mohamad Koohi-Moghadam, Junwen Wang, Jiang Xia, Yuchuan Wang
Publikováno v:
Metallomics : integrated biometal science. 9(1)
Metalloproteins account for nearly one-third of proteins in proteomes. To date, the identification of metalloproteins relies mainly on protein purification and the subsequent characterization of bound metals, which often leads to losses of metal ions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34aee6e1574b72885dec576cba5d953f
https://pubmed.ncbi.nlm.nih.gov/27830853
https://pubmed.ncbi.nlm.nih.gov/27830853
Publikováno v:
Metallomics : integrated biometal science. 5(7)
Spatially clustered histidines are commonly found in protein structures. The versatility of histidine coordination favors transition metal bindings, suggesting that spatially clustered histidines are potentially involved in metal binding and thereby
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbde242a85a8f9e5f3493abf9ecfba58
https://pubmed.ncbi.nlm.nih.gov/23771053
https://pubmed.ncbi.nlm.nih.gov/23771053