Zobrazeno 1 - 10
of 153
pro vyhledávání: '"YUKARI TAKAHASHI"'
Autor:
Sanae Inokuchi-Sakata, Ryo Narita, Yukari Takahashi, Yozo Ishiuji, Akihiko Asahina, Fusao Kato
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-21 (2024)
Abstract Itch is a protective/defensive function with divalent motivational drives. Itch itself elicits an unpleasant experience, which triggers the urge to scratch, relieving the itchiness. Still, it can also result in dissatisfaction when the scrat
Externí odkaz:
https://doaj.org/article/088b5a660c0b4a099db21963c53eedc8
Publikováno v:
Neurobiology of Pain, Vol 13, Iss , Pp 100131- (2023)
Nociplastic pain, the most recently proposed mechanistic descriptor of chronic pain, is the pain resulting from an altered nociceptive system and network without clear evidence of nociceptor activation, injury or disease in the somatosensory system.
Externí odkaz:
https://doaj.org/article/9a359a4eb9d34307975e1c188f41249d
Autor:
Takayuki Matsushita, Kazuhiro Otani, Yohsuke Oto, Yukari Takahashi, Daitaro Kurosaka, Fusao Kato
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-17 (2021)
Abstract Background Central nervous system (CNS)-mediated symptoms, such as fatigue, depression, and hyperalgesia, are common complications among patients with rheumatoid arthritis (RA). However, it remains unclear how the peripheral pathology of RA
Externí odkaz:
https://doaj.org/article/0d1d904cce5a40d18d8bd8a6aaae4135
Publikováno v:
Neurobiology of Pain, Vol 10, Iss , Pp 100078- (2021)
Pregabalin (PGB) is a synthetic amino acid compound most widely prescribed for chronic peripheral and central neuropathic pain. PGB is a ligand for the α2δ1 subunit of voltage-dependent calcium channels, and its binding reduces neurotransmitter rel
Externí odkaz:
https://doaj.org/article/a42f59f715894d319de74b5616f5685c
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-16 (2019)
Abstract Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis and bone destruction at the joints, causing pain and motor disturbance. Despite the better control of inflammation and joint deformity afforded
Externí odkaz:
https://doaj.org/article/d82c25c421024a8fa75f6e189b574e98
Autor:
Masao Doi, Hiroyuki Shimatani, Yuta Atobe, Iori Murai, Hida Hayashi, Yukari Takahashi, Jean-Michel Fustin, Yoshiaki Yamaguchi, Hiroshi Kiyonari, Nobuya Koike, Kazuhiro Yagita, Choogon Lee, Manabu Abe, Kenji Sakimura, Hitoshi Okamura
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
The circadian transcription factors BMAL1:CLOCK bind to E/E′-boxes in gene regulatory elements of their targets and facilitate rhythmic expression. Here, the authors mutate the Per2 promoter E’′-box in mice and observe that cell- and tissue-aut
Externí odkaz:
https://doaj.org/article/9f27d452176741a7b1daf82753a71800
Autor:
Daigo Arimura, Kei Shinohara, Yukari Takahashi, Yae K. Sugimura, Mariko Sugimoto, Tomokazu Tsurugizawa, Keishi Marumo, Fusao Kato
Publikováno v:
Frontiers in Neural Circuits, Vol 13 (2019)
Chronic pain is a major health problem, affecting 10–30% of the population in developed countries. While chronic pain is defined as “a persistent complaint of pain lasting for more than the usual period for recovery,” recently accumulated lines
Externí odkaz:
https://doaj.org/article/6ec59eed73654fc1943f3cf63b57a7fa
Autor:
Masanori Nomoto, Noriaki Ohkawa, Hirofumi Nishizono, Jun Yokose, Akinobu Suzuki, Mina Matsuo, Shuhei Tsujimura, Yukari Takahashi, Masashi Nagase, Ayako M. Watabe, Fusao Kato, Kaoru Inokuchi
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Short-term memories (STM) can become long-term memories when occurring alongside novel experiences. Here, the authors investigate the neural mechanisms behind such 'behavioural tagging' and find STM neural populations are preferentially incorporated
Externí odkaz:
https://doaj.org/article/404ad47d5d1047cb896cd764c13ac056
Autor:
Masao Doi, Iori Murai, Sumihiro Kunisue, Genzui Setsu, Naohiro Uchio, Rina Tanaka, Sakurako Kobayashi, Hiroyuki Shimatani, Hida Hayashi, Hsu-Wen Chao, Yuuki Nakagawa, Yukari Takahashi, Yunhong Hotta, Jun-ichirou Yasunaga, Masao Matsuoka, Michael H. Hastings, Hiroshi Kiyonari, Hitoshi Okamura
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The suprachiasmatic nucleus (SCN) is the central regulator of circadian rhythms. Here the authors identify mouse Gpr176 as a pace modulator of this circadian clock and characterize its mode of action as coupling to Gz rather than Gi subunits.
Externí odkaz:
https://doaj.org/article/c16b11b6441e475eb897bd5b32fd2eac
Autor:
Noriaki Ohkawa, Yoshito Saitoh, Akinobu Suzuki, Shuhei Tsujimura, Emi Murayama, Sakurako Kosugi, Hirofumi Nishizono, Mina Matsuo, Yukari Takahashi, Masashi Nagase, Yae K. Sugimura, Ayako M. Watabe, Fusao Kato, Kaoru Inokuchi
Publikováno v:
Cell Reports, Vol 11, Iss 2, Pp 261-269 (2015)
Memory is thought to be stored in the brain as an ensemble of cells activated during learning. Although optical stimulation of a cell ensemble triggers the retrieval of the corresponding memory, it is unclear how the association of information occurs
Externí odkaz:
https://doaj.org/article/a8b1352f226042c1b15233ea892aa484