Zobrazeno 1 - 10 of 127 pro vyhledávání: '"YUKAKO ITO"'
1
Akademický článek
Pharmacokinetics of Macrolide Antibiotics and Transport into the Interstitial Fluid: Comparison among Erythromycin, Clarithromycin, and Azithromycin
Autor: Shinji Kobuchi, Teruhiko Kabata, Koki Maeda, Yukako Ito, Toshiyuki Sakaeda
Publikováno v: Antibiotics, Vol 9, Iss 4, p 199 (2020)
Recent research has found higher levels and longer total exposure of azithromycin, a macrolide antibiotic agent, in the interstitial fluid of the skin than in the plasma. This unique distribution is expected to contribute to its antimicrobial activit
Externí odkaz: https://doaj.org/article/8216a7bc1e354a78a3583f0cb2d15f00
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2
Akademický článek
Semi-Mechanism-Based Pharmacokinetic-Toxicodynamic Model of Oxaliplatin-Induced Acute and Chronic Neuropathy
Autor: Shinji Kobuchi, Risa Shimizu, Yukako Ito
Publikováno v: Pharmaceutics, Vol 12, Iss 2, p 125 (2020)
Oxaliplatin (L-OHP) is widely prescribed for treating gastroenterological cancer. L-OHP-induced peripheral neuropathy is a critical toxic effect that limits the dosage of L-OHP. An ideal chemotherapeutic strategy that does not result in severe periph
Externí odkaz: https://doaj.org/article/2a3c6e6d51734a7ea9992e7d5bd67bb3
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4
Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats
Autor: Shinji, Kobuchi, Megumi, Matsui, Yukako, Ito
Publikováno v: Xenobiotica. 52:697-706
Myelosuppression is a dose-limiting toxicity of uracil-tegafur (UFT), which contains uracil and the 5‑fluorouracil prodrug tegafur, and inhibits the continuation of chemotherapy, causing treatment failure. A proper dosing strategy to avoid severe m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e69822fc7f2474841d1effbf198f09a
https://doi.org/10.1080/00498254.2022.2142696
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6
Assessment of Drug–drug Interaction and Optimization in Capecitabine and Irinotecan Combination Regimen using a Physiologically Based Pharmacokinetic Model
Autor: Shuhei Sakai, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
Publikováno v: Journal of Pharmaceutical Sciences. 111:1522-1530
Capecitabine and irinotecan (CPT-11) combination regimen (XELIRI) is used for colorectal cancer treatment. Capecitabine is metabolized to 5-fluorouracil (5-FU) by three enzymes, including carboxylesterase (CES). CES can also convert CPT-11 to 7-ethyl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9d9661e2e6f6c7486d037808068958
https://doi.org/10.1016/j.xphs.2021.12.021
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7
Comparison of In Vivo Transportability of Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Agents Into Intracellular and Extracellular Tissue Spaces in Rats
Autor: Yukako Ito, Shinji Kobuchi, Kenji Sasaki, Yusuke Kita, Yukiko Hiramatsu, Tomoya Uno, Toshiyuki Sakaeda
Publikováno v: Journal of Pharmaceutical Sciences. 110:898-904
The pathogenic bacterium Staphylococcus aureus can penetrate host cells. However, intracellular S. aureus is not considered during antimicrobial agent selection in clinical chemotherapy because of the lack of information about drug transportability i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c7733b0e21c399668bf437361219cc
https://doi.org/10.1016/j.xphs.2020.09.045
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8
Cytology-based Detection of Circulating Tumour Cells in Human Pancreatic Cancer Xenograft Models With KRAS Mutation
Autor: Yuzuru Ikehara, Mayumi Yoshimura, Yuki Matsui, Susumu Nakata, Yukako Ito, Kikuko Amagase, Hayao Nakanishi, Shinji Kobuchi, Chiami Moyama, Eriko Inoue
Publikováno v: Anticancer Research. 40:6781-6789
Background/aim To examine the dynamics of circulating tumour cells (CTCs) in pancreatic cancer (PC), new mouse CTC models from human PC xenografts were developed. Materials and methods Orthotopic (pancreas) and heterotopic (subcutaneous) transplantat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff5daa42d7c2584b94333ce223bbf5aa
https://doi.org/10.21873/anticanres.14701
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9
Population Pharmacokinetic Model-Based Evaluation of Intact Oxaliplatin in Rats with Acute Kidney Injury
Autor: Shinji Kobuchi, Miyu Kai, Yukako Ito
Publikováno v: Cancers, Vol 13, Iss 6382, p 6382 (2021)
Cancers; Volume 13; Issue 24; Pages: 6382
Cancers
Simple Summary Acute kidney injury (AKI) complicates the dose setting of oxaliplatin (L-OHP), making it difficult to continue treatment cycles and retain antitumor efficacies with minimum L-OHP-related toxicities. Our study aimed to assess the impact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0761b66d865ab5992e1e2e6c680e1b74
https://www.mdpi.com/2072-6694/13/24/6382
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10
Pharmacokinetics and lung distribution of macrolide antibiotics in sepsis model rats
Autor: Hiromu Kobayashi, Akihiro Fujita, Shinji Kobuchi, Toshiyuki Sakaeda, Yukako Ito, Akihito Kato
Publikováno v: Xenobiotica. 50:552-558
Recent studies have shown azithromycin-specific clinical efficacy against macrolide-resistant strains of Streptococcus pneumoniae, despite the low susceptibility of the bacteria in vitro. This discrepancy complicates dosing and selection for treatmen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40795341bac0543da1894af5c6f17081
https://doi.org/10.1080/00498254.2019.1654633
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