Zobrazeno 1 - 10
of 3 591
pro vyhledávání: '"YU Gui"'
Publikováno v:
Journal of Advanced Research, Vol 63, Iss , Pp 207-218 (2024)
Background: Aging, a complex and profound journey, leads us through a labyrinth of physiological and pathological transformations, rendering us increasingly susceptible to aging-related diseases. Emerging investigations have unveiled the function of
Externí odkaz:
https://doaj.org/article/036944c09f8e4695852137b8a918b19d
Autor:
Zhuan Feng, Feiyang Meng, Fei Huo, Yumeng Zhu, Yifei Qin, Yu Gui, Hai Zhang, Peng Lin, Qian He, Yong Li, Jiejie Geng, Jiao Wu
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103255- (2024)
Ferroptosis is a type of programmed cell death driven by iron-dependent lipid peroxidation. The TNF-mediated biosynthesis of glutathione has been shown to protect synovial fibroblasts from ferroptosis in the hyperplastic synovium. Ferroptosis inducti
Externí odkaz:
https://doaj.org/article/6ba34bdf33944c9097523c08c4f74c45
Autor:
Yumei Wang, Haiyan Wang, Wei Shao, Yuhui Chen, Yu Gui, Chao Hu, Xiaohong Yi, Lijun Huang, Shasha Li, Dong Wang
Publikováno v:
Cancer Biology & Medicine, Vol 21, Iss 1, Pp 83-103 (2024)
Objective: Epigenetic abnormalities have a critical role in breast cancer by regulating gene expression; however, the intricate interrelationships and key roles of approximately 400 epigenetic regulators in breast cancer remain elusive. It is importa
Externí odkaz:
https://doaj.org/article/b19f4139df534722b75faf9d1daabcae
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a human paracaspase protein with proteolytic activity via its caspase-like domain. The pharmacological inhibition of MALT1 by MI-2, a specific chemical inhibitor,
Externí odkaz:
https://doaj.org/article/07dbb6bad4024d5aa399a2ef7d8a6af9
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 19, Iss 1, Pp 1-5 (2023)
Abstract Background Secukinumab has been approved by the U.S. FDA and the European Medicines Agency for the treatment of moderate-to-severe plaque psoriasis and psoriatic arthritis with the documented adverse effects. Here we reported in one case tha
Externí odkaz:
https://doaj.org/article/b4125eedbb294cca8a67a39303fbd854
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Neointima lesion and atherosclerosis are proliferative vascular diseases associated with deregulated proliferation of vascular smooth muscle cells (SMCs). CFI-400945 is a novel, highly effective anticancer drug that inhibits polo-like kinase
Externí odkaz:
https://doaj.org/article/f98653eed3db4c748f214c1b257303cf
Autor:
Jianwei Liao, Yu Gui, Zhilin Li, Zijian Deng, Xianfeng Han, Huanhuan Tian, Li Cai, Xingyu Liu, Chengyong Tang, Jia Liu, Ya Wei, Lan Hu, Fengling Niu, Jing Liu, Xi Yang, Shichao Li, Xiang Cui, Xin Wu, Qingqiu Chen, Andi Wan, Jun Jiang, Yi Zhang, Xiangdong Luo, Peng Wang, Zhigang Cai, Li Chen
Publikováno v:
EClinicalMedicine, Vol 60, Iss , Pp 102001- (2023)
Summary: Background: Early diagnosis of breast cancer has always been a difficult clinical challenge. We developed a deep-learning model EDL-BC to discriminate early breast cancer with ultrasound (US) benign findings. This study aimed to investigate
Externí odkaz:
https://doaj.org/article/5054abf59f3344279d467fdd6f67cf1f
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 252, Iss , Pp 114626- (2023)
Excess intake of fluoride leads to a serious health issue called fluorosis. Fluorosis patients exhibit the symptom of muscle damage, but the specific mechanism remains unclear. Fibroblast growth factor 21 (FGF21) is a novel myokine that is involved i
Externí odkaz:
https://doaj.org/article/664bbf5333e94c87b642163e7ff60d25
Autor:
Yu Gui, Yifei Dai, Yumei Wang, Shengrong Li, Lei Xiang, Yuqin Tang, Xue Tan, Tianli Pei, Xilinqiqige Bao, Dong Wang
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3461-3472 (2022)
Taohong Siwu Decoction (TSD), a classical gynecological prescription that was firstly reported 600 years ago, has been widely used in the adjuvant treatment of breast cancer (BRCA) in China. However, the mechanism of action of TSD in treating BRCA ha
Externí odkaz:
https://doaj.org/article/c44ea3de66fa438a84b2380bec92c2a2
Autor:
Binjie Yan, Yu Gui, Yanan Guo, Jiaxing Sun, Mahmoud Saifeddine, Jingti Deng, Joseph A. Hill, Morley D. Hollenberg, Zhi-Sheng Jiang, Xi-Long Zheng
Publikováno v:
Cells, Vol 12, Iss 11, p 1461 (2023)
(+)-JQ1, a specific chemical inhibitor of bromodomain and extraterminal (BET) family protein 4 (BRD4), has been reported to inhibit smooth muscle cell (SMC) proliferation and mouse neointima formation via BRD4 regulation and modulate endothelial nitr
Externí odkaz:
https://doaj.org/article/535596f615e049e9b1c483968d52f6c2