Zobrazeno 1 - 10
of 707
pro vyhledávání: '"YTHDF2"'
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-24 (2024)
Abstract This study investigates the potential molecular mechanisms by which O-GlcNAc modification of YTHDF2 regulates the cell cycle and participates in intervertebral disc degeneration (IDD). We employed transcriptome sequencing to identify genes i
Externí odkaz:
https://doaj.org/article/298142973bb54ec1b72d612b051185cd
Publikováno v:
Journal of Advanced Research, Vol 63, Iss , Pp 17-33 (2024)
Introduction: Epigenetic alterations play crucial roles in diffuse large B-cell lymphoma (DLBCL). Disturbances in lipid metabolism contribute to tumor progression. However, studies in epigenetics, especially its critical regulator YTH N6-methyladenos
Externí odkaz:
https://doaj.org/article/5b69ca6eaee847cfa509213a96418200
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background KIAA1429, a regulatory subunit of the N6-methyladenosine (m6A) methyltransferase complex, has been implicated in the progression of various cancers. However, the role of KIAA1429 in gastric cancer (GC) and its underlying mechanism
Externí odkaz:
https://doaj.org/article/de8f8ea7e6244dfaab11c6d158d8dc04
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundColorectal cancer (CRC) ranks as the third most prevalent malignant neoplasm in terms of both morbidity and mortality. Within the tumor microenvironment (TME) of CRC, the diminished presence and diminished cytotoxic function of natural kill
Externí odkaz:
https://doaj.org/article/7079da91ca4d44ce81cb24bc4a4b3ca5
Autor:
Haonan Huang, Yu Lin, Jinge Xin, Ning Sun, Zhifang Zhao, Hesong Wang, Lixiao Duan, Yanxi Zhou, Xingmei Liu, Jing Fang, Bo Jing, Kangcheng Pan, Yan Zeng, Dong Zeng, Hao Li, Hailin Ma, Yang Bai, Limin Wei, Xueqin Ni
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 283, Iss , Pp 116816- (2024)
Fluoride exposure is widespread worldwide and poses a significant threat to organisms, particularly to their gastrointestinal tracts. However, due to limited knowledge of the mechanism of fluoride induced intestinal injury, it has been challenging to
Externí odkaz:
https://doaj.org/article/64da8c535fb844ae983d02ecf98b85a9
Autor:
Peng Yu, Tutu Xu, Wenmeng Ma, Xiang Fang, Yue Bao, Chengran Xu, Jinhai Huang, Yongqing Sun, Guangyu Li
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)
Abstract Background Protein arginine methyltransferase 6 (PRMT6) plays a crucial role in various pathophysiological processes and diseases. Glioblastoma (GBM; WHO Grade 4 glioma) is the most common and lethal primary brain tumor in adults, with a pro
Externí odkaz:
https://doaj.org/article/91adf7b8b68d41ceb15bfa535c3a072e
Autor:
Fujian Wan, Fengwu Qiu, Yang Deng, Hao Hu, Yingjie Zhang, Jia-Yu Zhang, Pei Kuang, Haoyu Tian, Dewang Wu, Hang Min, Jiapeng Li, Jing Xu, Jun Zhou
Publikováno v:
Translational Oncology, Vol 46, Iss , Pp 101994- (2024)
Cervical cancer ranks fourth in women in terms of incidence and mortality. The RNA-binding protein YTH N6-methyladenosine RNA-binding protein F2 (YTHDF2) contributes to cancer progression by incompletely understood mechanisms. We show how YTHDF2 cont
Externí odkaz:
https://doaj.org/article/a6055bab33d74282b1412bb4fe725f93
Silencing of FTO inhibits oxidative stress to relieve neuropathic pain by m6A modification of GPR177
Publikováno v:
Immunity, Inflammation and Disease, Vol 12, Iss 7, Pp n/a-n/a (2024)
Abstract Background Neuropathic pain (NP) is a challenging health condition owing to its complex nature and associated multiple etiologies. The occurrence of NP involves the abnormal activity of neurons mediated by oxidative stress (OS). Previous res
Externí odkaz:
https://doaj.org/article/2cf2f37a3b5046c3ab3d594cbd1e554a
Autor:
Zheng Zhang, Keren Zhou, Li Han, Andrew Small, Jianhuang Xue, Huilin Huang, Hengyou Weng, Rui Su, Brandon Tan, Chao Shen, Wei Li, Zhicong Zhao, Ying Qing, Xi Qin, Kitty Wang, Keith Leung, Mark Boldin, Chun-Wei Chen, David Ann, Zhijian Qian, Xiaolan Deng, Jianjun Chen, Zhenhua Chen
Publikováno v:
Genes and Diseases, Vol 11, Iss 1, Pp 382-396 (2024)
As the most common internal modification of mRNA, N6-methyladenosine (m6A) and its regulators modulate gene expression and play critical roles in various biological and pathological processes including tumorigenesis. It was reported previously that m
Externí odkaz:
https://doaj.org/article/bd64f8356dfc4a9a8e981d1b56e09447
Autor:
Hao Gu, Kang Xu, Zhao Yu, Zufeng Ren, Fan Chen, Changfan Zhou, Wei Zeng, Hongyan Ren, Yulong Yin, Yanzhen Bi
Publikováno v:
Cells, Vol 13, Iss 20, p 1744 (2024)
N6-methyladenosine (m6A) is the most common modification in eukaryotic RNAs. Growing research indicates that m6A methylation is crucial for a multitude of biological processes. However, research on the m6A modifications in the regulation of porcine m
Externí odkaz:
https://doaj.org/article/c5cdefb7b9cc415f8f713780e95131a1