Zobrazeno 1 - 10
of 357
pro vyhledávání: '"YOSHIYUKI KAKEHI"'
Autor:
Mikio Sugimoto, Takuma Kato, Yoichiro Tohi, Yosuke Shimizu, Ryuji Matsumoto, Takahiro Inoue, Yutaka Takezawa, Kimihiko Masui, Hiroshi Sasaki, Hiromi Hirama, Shiro Saito, Shin Egawa, Toshiyuki Kamoto, Satoshi Teramukai, Shinsuke Kojima, Takashi Kikuchi, Yoshiyuki Kakehi
Publikováno v:
BMC Urology, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background The effect of enzalutamide in patients with non-metastatic castration-resistant prostate cancer after combined androgen blockade, which represents a patient profile similar to real-world clinical practice in Japan, remains unknown
Externí odkaz:
https://doaj.org/article/47ab820ca54d4404bd9dc27ded9a1e9d
Autor:
Hiroji Uemura, Kazuki Kobayashi, Akira Yokomizo, Shiro Hinotsu, Shigeo Horie, Yoshiyuki Kakehi, Seiji Naito, Norio Nonomura, Osamu Ogawa, Mototsugu Oya, Kazuhiro Suzuki, Atsushi Saito, Satoshi Uno, Hideyuki Akaza
Publikováno v:
BJUI Compass, Vol 3, Iss 1, Pp 26-36 (2022)
Abstract Objectives The objective of the study is to compare the efficacy and safety of alternative androgen therapy (AAT) with enzalutamide + androgen deprivation therapy (ADT) and flutamide + ADT in the treatment of Japanese men with metastatic or
Externí odkaz:
https://doaj.org/article/950d71e9d12a449d8a1931c77272df3a
Autor:
Naoki Terada, Toshiyuki Kamoto, Hiromasa Tsukino, Shoichiro Mukai, Shusuke Akamatsu, Takahiro Inoue, Osamu Ogawa, Shintaro Narita, Tomonori Habuchi, Shinichi Yamashita, Koji Mitsuzuka, Yoichi Arai, Shuya Kandori, Takahiro Kojima, Hiroyuki Nishiyama, Yoshiaki Kawamura, Yuki Shimizu, Toshiro Terachi, Motohiko Sugi, Hidefumi Kinoshita, Tadashi Matsuda, Yusuke Yamada, Shingo Yamamoto, Hiromi Hirama, Mikio Sugimoto, Yoshiyuki Kakehi, Toshihiko Sakurai, Norihiko Tsuchiya
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-7 (2019)
Abstract Background We analyzed the efficacy and toxicity of cabazitaxel (CBZ) at high and low initial doses in Japanese patients with docetaxel-resistant castration-resistant prostate cancer (CRPC). Methods We retrospectively evaluated 118 patients
Externí odkaz:
https://doaj.org/article/fcb229df7cf7437ba285d18cf38f4b7d
Autor:
Yoichiro Tohi, Rikiya Taoka, Xia Zhang, Yuki Matsuoka, Akihide Yoshihara, Emi Ibuki, Reiji Haba, Kazuya Akimitsu, Ken Izumori, Yoshiyuki Kakehi, Mikio Sugimoto
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6771 (2022)
D-allose is a rare sugar that has been reported to up-regulate thioredoxin-interacting protein (TXNIP) expression and affect the production of intracellular reactive oxygen species (ROS). However, the antitumor effect of D-allose is unknown. This stu
Externí odkaz:
https://doaj.org/article/d5092ac77fe6462cbd372f8e25ccc7ef
Autor:
Shunji Takahashi, Seigo Kinuya, Norio Nonomura, Nobuo Shinohara, Kazuhiro Suzuki, Hiroyoshi Suzuki, Katsumasa Nakamura, Takefumi Satoh, Ukihide Tateishi, Toshiyuki Yoneda, Hiroyuki Horikoshi, Tsukasa Igawa, Takao Kamai, Mitsuru Koizumi, Takeo Kosaka, Nobuaki Matsubara, Hideaki Miyake, Atsushi Mizokami, Takashi Mizowaki, Naoki Nakamura, Masahiro Nozawa, Takeo Takahashi, Hiroji Uemura, Motohide Uemura, Akira Yokomizo, Mana Yoshimura, Yoshiyuki Kakehi
Publikováno v:
Oncology and Therapy, Vol 6, Iss 2, Pp 157-171 (2018)
Abstract Introduction The incidence of prostate cancer in Japan continues to increase, necessitating the continued development of effective therapies and strategies. Recent advances in treatments have improved the prognosis of metastatic disease and
Externí odkaz:
https://doaj.org/article/39f60399f876455299e1113900fc8ff0
Autor:
Rikiya Taoka, Yoshiyuki Kakehi
Publikováno v:
Asian Journal of Urology, Vol 4, Iss 3, Pp 158-163 (2017)
Benign prostatic hyperplasia (BPH) is a condition that greatly affects the quality of life of middle-aged and elderly men. Histopathologically, hyperplastic changes frequently occur in the prostate tissue of elderly men, the incidence of which has be
Externí odkaz:
https://doaj.org/article/2c29d3261b774a5986590af79e059666
Autor:
Xia Zhang, Rikiya Taoka, Dage Liu, Yuki Matsuoka, Yoichiro Tohi, Yoshiyuki Kakehi, Mikio Sugimoto
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 4102 (2021)
RRM1—an important DNA replication/repair enzyme—is the primary molecular gemcitabine (GEM) target. High RRM1-expression associates with gemcitabine-resistance in various cancers and RRM1 inhibition may provide novel cancer treatment approaches. O
Externí odkaz:
https://doaj.org/article/73037e5b9ab8431cb3750a97a93cf4b2
Autor:
Kazuyuki Hirooka, Kaori Ukegawa, Eri Nitta, Nobufumi Ueda, Yushi Hayashida, Hiromi Hirama, Rikiya Taoka, Yuma Sakura, Mari Yamasaki, Hiroyuki Tsunemori, Mikio Sugimoto, Yoshiyuki Kakehi
Publikováno v:
Journal of Ophthalmology, Vol 2018 (2018)
Purpose. Robotic-assisted laparoscopic radical prostatectomy (RALP) has become a standard treatment choice for localized prostate cancer. RALP requires a steep Trendelenburg position, which leads to a significant increase in intraocular pressure (IOP
Externí odkaz:
https://doaj.org/article/f9718c5649ae4408ae483547d532f61d
Autor:
Xia Zhang, Dage Liu, Yushi Hayashida, Homare Okazoe, Takeshi Hashimoto, Nobufumi Ueda, Mikio Sugimoto, Yoshiyuki Kakehi
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 10, Pp 24319-24331 (2015)
G protein-coupled receptor 87 (GPR87) is a newly deorphanized member of the cell surface molecule G protein-coupled receptor family. GPR signaling was shown to play a role in promotion of cell growth and survival, metastasis, and drug resistance. The
Externí odkaz:
https://doaj.org/article/4a905072c5144f2cbdde96eb0c540ec0
Autor:
Yoshiyuki Kakehi, Mikio Sugimoto, Nobufumi Ueda, Shinsuke Shibuya, Dage Liu, Xia Zhang, Homare Okazoe
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 6, Pp 12367-12379 (2013)
The orphan GPR87 has recently been matched with its ligand LPA, which is a lipid mediator with multiple physiological functions, including cancer cell proliferation. This study aimed to clarify the role of GPR87 in urothelial carcinoma of the bladder
Externí odkaz:
https://doaj.org/article/0c508253da5646b9803c706327571e64