Zobrazeno 1 - 10
of 54
pro vyhledávání: '"YOSHINOBU YAMAZAKI"'
Autor:
Yoshitaka Tomiyama, Makoto Murakami, Kohichi Hayakawa, Katsuyoshi Akiyama, Yoshinobu Yamazaki, Masami Kojima, Nobuo Shibata, Masuo Akahane
Publikováno v:
Journal of Pharmacological Sciences, Vol 92, Iss 4, Pp 411-419 (2003)
Since, in the human ureter, both β2- and β3-adrenoceptors mediate adrenergic-stimulation-induced relaxation, selective β2-/β3-adrenoceptor agonists might prove clinically useful for relieving ureteral colic and promoting stone passage. We evaluat
Externí odkaz:
https://doaj.org/article/06363c70edbd48bf866b9f1e881497f3
Autor:
Yoshinobu Yamazaki, Yuji Hoyano, Itaru Maruyama, Kazuyasu Maruyama, Satoshi Tatemichi, Yoshiaki Goi, Hiroshi Kusama
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 385:845-852
We performed in vitro and in vivo experiments to evaluate the pharmacological profile of ritobegron and its effects on the bladder in rats. β3-AR selectivity was assessed using CHO cells expressing various subtypes of the human β-adrenoceptor (AR).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dda0a8b8830b681c6aa40afee2c3355
https://doi.org/10.1007/s00210-012-0755-x
https://doi.org/10.1007/s00210-012-0755-x
Autor:
Itaru Maruyama, Hiroshi Kusama, Yuji Hoyano, Kazuyasu Maruyama, Satoshi Tatemichi, Saori Yonekubo, Yoshinobu Yamazaki
Publikováno v:
Journal of Smooth Muscle Research. 48:115-124
The objective of this study was to investigate the effects of the β3-adrenoceptor (AR) agonist ritobegron on rat bladder function following partial bladder outlet obstruction and on rat salivary secretion. In addition, the effects of ritobegron were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81114e8e77f55c160bfb3713d10aec79
https://doi.org/10.1540/jsmr.48.115
https://doi.org/10.1540/jsmr.48.115
Autor:
Yoshinobu Yamazaki, Kiyoshi Ichikawa, Masami Kojima, Kumi Kobayashi, Takahiro Imamura, Sumiyoshi Kiguchi
Publikováno v:
Arzneimittelforschung. 53:688-694
The effects of ozagrel (CAS 82571-53-7), a thromboxane A2-synthetase inhibitor, and norphenazone (CAS 89-25-8), a free-radical scavenger, on cerebral infarction were assessed using the suture-induced middle cerebral artery occlusion (MCAO) model and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01bd97ac138c4fb8e41a9d1a13549528
https://doi.org/10.1055/s-0031-1299813
https://doi.org/10.1055/s-0031-1299813
Autor:
Mamoru Kobayashi, Nobuo Shibata, Yoshinobu Yamazaki, Satoshi Tatemichi, Tsutomu Uruno, Sumiyoshi Kiguchi
Publikováno v:
Arzneimittelforschung. 56:682-687
The aim of this study was to assess the cardiovascular effects of silodosin (CAS 160970-54-7, (-)-1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy) phenoxy]ethyllamino)propyll-2,3-dihy-dro-1H-indole-7-carboxamide, KMD-3213), a potent selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b945ad4dcf248e3ec56edf57eadf495d
https://doi.org/10.1055/s-0031-1296773
https://doi.org/10.1055/s-0031-1296773
Autor:
Yoshinobu Yamazaki, Yoshitaka Tomiyama, Mamoru Kobayashi, Satoshi Tatemichi, Shinya Kobayashi, Yuji Hoyano
Publikováno v:
European Journal of Pharmacology. 613:135-140
We examined whether the effects (efficacy on the urethra and hypotension) of silodosin (alpha(1A)-adrenoceptor antagonist) and tamsulosin (alpha(1A+1D)-adrenoceptor antagonist) in dogs with benign prostatic hyperplasia altered with age. We used young
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416a8d574efd910033895f74ce5c4203
https://doi.org/10.1016/j.ejphar.2009.04.030
https://doi.org/10.1016/j.ejphar.2009.04.030
Autor:
Yasue Kubota, Yoshitaka Tomiyama, Yoshinobu Yamazaki, Hiroshi Kusama, Kenjiro Kohri, Yasunori Itoh, Yuji Hoyano, Shinya Kobayashi
Publikováno v:
World Journal of Urology. 27:775-780
This study was performed to characterize the α1-adrenoceptor subtypes in mouse ureters as regards gene expressions and contractile functions.The mRNAs for these subtypes were quantified by the real-time quantitative reverse transcription polymerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5defb56cbf66e29dbedc6db4d9033ec0
https://doi.org/10.1007/s00345-009-0396-y
https://doi.org/10.1007/s00345-009-0396-y
Autor:
Yoshinobu Yamazaki, Hiroshi Kusama, Shinya Kobayashi, Yuji Hoyano, Kazuyasu Maruyama, Yoshitaka Tomiyama
Publikováno v:
Journal of Smooth Muscle Research. 45:187-195
To compare the efficacy of the selective alpha(1A)-adrenoceptor antagonist silodosin with those of doxazosin, terazosin, and alfuzosin against alpha-adrenoceptor agonist-induced contractions in mouse and hamster ureters.The four alpha(1)-adrenoceptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efb36e188b903da3a188271b794ca33
https://doi.org/10.1540/jsmr.45.187
https://doi.org/10.1540/jsmr.45.187
Autor:
Shigeru Nakano, Toru Tamura, Junji Kuroda, Kazuyasu Maruyama, Yoshinobu Yamazaki, Tatsuya Nagasawa, Tetsuaki Takahashi, Yoichi Inada, Nobuo Shibata
Publikováno v:
European Journal of Pharmacology. 536:182-191
We evaluated the effects of bezafibrate, a peroxisome proliferator-activated receptor (PPAR) pan-agonist, and GW501516, a PPARdelta agonist, on mice fed a methionine- and choline-deficient (MCD) diet, a model of non-alcholic steatohepatitis (NASH), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d318f132849d8743b13fceef2c58be0a
https://doi.org/10.1016/j.ejphar.2006.02.028
https://doi.org/10.1016/j.ejphar.2006.02.028
Autor:
Itaru Maruyama, Yoshinobu Yamazaki, Kumi Kobayashi, Ayaka Maezawa, Mamoru Kobayashi, Satoshi Tatemichi, Yoshitaka Tomiyama, Nobuo Shibata, Shinya Kobayashi
Publikováno v:
Neurourology and Urodynamics. 25:792-799
Aims Our main aim was to compare the prostatic selectivity of silodosin with that of other α1-adrenoceptor (AR) antagonists. Methods We examined uroselectivities in two sets of experiments namely, in vitro and in vivo functional studies using male d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ecf0f405e07185093447147bc710957
https://doi.org/10.1002/nau.20312
https://doi.org/10.1002/nau.20312