Zobrazeno 1 - 10
of 64
pro vyhledávání: '"YOSHIHITO KANO"'
Autor:
Nobuhiko Ogasawara, Yoshihito Kano, Yosuke Yoneyama, Sakurako Kobayashi, Satoshi Watanabe, Sakura Kirino, Fausto D. Velez-Bravo, Yourae Hong, Aleksandra Ostapiuk, Pavlo Lutsik, Iichiroh Onishi, Shinichi Yamauchi, Yui Hiraguri, Go Ito, Yusuke Kinugasa, Kenichi Ohashi, Mamoru Watanabe, Ryuichi Okamoto, Sabine Tejpar, Shiro Yui
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109247- (2024)
Summary: In normal intestines, a fetal/regenerative/revival cell state can be induced upon inflammation. This plasticity in cell fate is also one of the current topics in human colorectal cancer (CRC). To dissect the underlying mechanisms, we generat
Externí odkaz:
https://doaj.org/article/b7c4b22989424e7d86277299f9e37c54
Publikováno v:
Current Oncology, Vol 30, Iss 7, Pp 6546-6558 (2023)
Colorectal cancer (CRC) is the second most common cause of cancer-related deaths worldwide. The 5-year survival rate after curative resection is almost 80%, however, it is still less than satisfactory for metastatic CRC (mCRC). The combination approa
Externí odkaz:
https://doaj.org/article/34e28249a2024538b21832dbd9ce675d
Autor:
Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Yosuke Yoneyama, Sakura Kirino, Yui Hiraguri, Masami Inoue, Sayaka Nagata, Yoshimi Okamoto-Uchida, Satoshi Kofuji, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Shinichi Yamauchi, Yusuke Kinugasa, Yoshihito Kano, Yasuhiro Nemoto, Mamoru Watanabe, Kiichiro Tsuchiya, Hiroshi Nishina, Ryuichi Okamoto, Shiro Yui
Publikováno v:
Inflammation and Regeneration, Vol 42, Iss 1, Pp 1-18 (2022)
Abstract Background The emerging concepts of fetal-like reprogramming following tissue injury have been well recognized as an important cue for resolving regenerative mechanisms of intestinal epithelium during inflammation. We previously revealed tha
Externí odkaz:
https://doaj.org/article/0b1ef15512e247f5a2f38806a4814691
Autor:
Takahiro Naito, Rika Noji, Takuma Kugimoto, Takeshi Kuroshima, Hirofumi Tomioka, Shun Fujiwara, Mitsukuni Suenaga, Hiroyuki Harada, Yoshihito Kano
Publikováno v:
Medicina, Vol 59, Iss 12, p 2111 (2023)
Background and Objectives: Adenoid cystic carcinoma (ACC) of the head and neck is generally slow-growing but has a high potential for local recurrence and metastasis to distant organs. There is currently no standard pharmacological treatment for recu
Externí odkaz:
https://doaj.org/article/6880d07b7d6346b18fbf9b8fc064cbf1
Autor:
Teklab Gebregiworgis, Yoshihito Kano, Jonathan St-Germain, Nikolina Radulovich, Molly L. Udaskin, Ahmet Mentes, Richard Huang, Betty P. K. Poon, Wenguang He, Ivette Valencia-Sama, Claire M. Robinson, Melissa Huestis, Jinmin Miao, Jen Jen Yeh, Zhong-Yin Zhang, Meredith S. Irwin, Jeffrey E. Lee, Ming-Sound Tsao, Brian Raught, Christopher B. Marshall, Michael Ohh, Mitsuhiko Ikura
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
SHP2 promotes RAS-driven MAPK signalling, but it is unclear why cancer cells with distinct KRAS mutations exhibit differential sensitivity to SHP2 inhibition. Here the authors show that KRAS Q61H is decoupled from SHP2- mediated upstream regulation,
Externí odkaz:
https://doaj.org/article/adc5eaa39af340409424aef1fcf1144b
Autor:
Federica Liotti, Narender Kumar, Nella Prevete, Maria Marotta, Daniela Sorriento, Caterina Ieranò, Andrea Ronchi, Federica Zito Marino, Sonia Moretti, Renato Colella, Efiso Puxeddu, Simona Paladino, Yoshihito Kano, Michael Ohh, Stefania Scala, Rosa Marina Melillo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
Abstract Background The programmed cell death-1 (PD-1) receptor and its ligands PD-L1 and PD-L2 are immune checkpoints that suppress anti-cancer immunity. Typically, cancer cells express the PD-Ls that bind PD-1 on immune cells, inhibiting their acti
Externí odkaz:
https://doaj.org/article/2f4f62c217e14f8f9af474f8e752ef34
Autor:
Yasuko Aoyagi, Yoshihito Kano, Kohki Tohyama, Shotaro Matsudera, Yuichi Kumaki, Kenta Takahashi, Takahiro Mitsumura, Yohei Harada, Akemi Sato, Hideaki Nakamura, Eisaburo Sueoka, Naoko Aragane, Koichiro Kimura, Iichiro Onishi, Akira Takemoto, Keiichi Akahoshi, Hiroaki Ono, Toshiaki Ishikawa, Masanori Tokunaga, Tsuyoshi Nakagawa, Noriko Oshima, Reiko Nakamura, Masatoshi Takagi, Takahiro Asakage, Hiroyuki Uetake, Minoru Tanabe, Satoshi Miyake, Yusuke Kinugasa, Sadakatsu Ikeda
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0266112 (2022)
IntroductionClinical sequencing has provided molecular and therapeutic insights into the field of clinical oncology. However, despite its significance, its clinical utility in Japanese patients remains unknown. Here, we examined the clinical utility
Externí odkaz:
https://doaj.org/article/2d1ed8713e5f48a4af69a7ed04fce8fc
Autor:
Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall, Nikolina Radulovich, Betty P. K. Poon, Jonathan St-Germain, Jonathan D. Cook, Ivette Valencia-Sama, Benjamin M. M. Grant, Silvia Gabriela Herrera, Jinmin Miao, Brian Raught, Meredith S. Irwin, Jeffrey E. Lee, Jen Jen Yeh, Zhong-Yin Zhang, Ming-Sound Tsao, Mitsuhiko Ikura, Michael Ohh
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Deregulation of the RAS GTPase cycle due to mutations in RAS genes is commonly associated with cancer development. Here authors use NMR and mass spectrometry to shows that KRAS phosphorylation via Src alters the conformation of switch I and II region
Externí odkaz:
https://doaj.org/article/811fdf81e7164853822f6750cc8b6260
Autor:
MITSUKUNI SUENAGA, SHINICHI YAMAUCHI, RYO MORIKAWA, RIKA NOJI, YOSHIHITO KANO, MASANORI TOKUNAGA, YUSUKE KINUGASA
Publikováno v:
In Vivo; May/Jun2024, Vol. 38 Issue 3, p1278-1284, 7p
Autor:
Shun Kaneko, Yasuhiro Asahina, Mina Nakagawa, Miyako Murakawa, Yasunari Miyazaki, Takahiro Asakage, Shohei Fukuda, Takeshi Namiki, Yoshihito Kano, Masashi Nagata, Jun Tsuchiya, Masato Miyoshi, Fukiko Kitahata‐Kawai, Sayuri Nitta, Yasuhiro Itsui, Sei Kakinuma, Ryuichi Okamoto
Publikováno v:
Hepatology Research. 53:450-459
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6e4f464658f0b15c7879ba469719119
https://doi.org/10.1111/hepr.13878
https://doi.org/10.1111/hepr.13878