Zobrazeno 1 - 10
of 402
pro vyhledávání: '"YOSHIHIRO BABA"'
Autor:
Yuichi Saito, Akihito Harada, Miho Ushijima, Kaori Tanaka, Ryota Higuchi, Akemi Baba, Daisuke Murakami, Stephen L. Nutt, Takashi Nakagawa, Yasuyuki Ohkawa, Yoshihiro Baba
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The differentiation of B cells into plasma cells is associated with substantial transcriptional and epigenetic remodeling. H3.3 histone variant marks active chromatin via replication-independent nucleosome assembly. However, its role in plas
Externí odkaz:
https://doaj.org/article/00f2e6ab5dc543d1a108045a01dd92fc
Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis
Autor:
Toyoshi Yanagihara, Kentaro Hata, Keisuke Matsubara, Kazufumi Kunimura, Kunihiro Suzuki, Kazuya Tsubouchi, Satoshi Ikegame, Yoshihiro Baba, Yoshinori Fukui, Isamu Okamoto
Publikováno v:
eLife, Vol 12 (2024)
Anticancer treatments can result in various adverse effects, including infections due to immune suppression/dysregulation and drug-induced toxicity in the lung. One of the major opportunistic infections is Pneumocystis jirovecii pneumonia (PCP), whic
Externí odkaz:
https://doaj.org/article/4bdf138ae02b404eab891b71b7b66cdc
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Sepsis is a systemic inflammatory response to a severe, life-threatening infection with organ dysfunction. Although there is no effective treatment for this fatal illness, a deeper understanding of the pathophysiological basis of sepsis and its under
Externí odkaz:
https://doaj.org/article/a8865bc8ab404de9aa0a5bbd9fbaafc0
Autor:
Chisato Ono, Shinya Tanaka, Keiko Myouzen, Takeshi Iwasaki, Mahoko Ueda, Yoshinao Oda, Kazuhiko Yamamoto, Yuta Kochi, Yoshihiro Baba
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
B cell anergy plays a critical role in maintaining self-tolerance by inhibiting autoreactive B cell activation to prevent autoimmune diseases. Here, we demonstrated that Fc receptor-like 5 (Fcrl5) upregulation contributes to autoimmune disease pathog
Externí odkaz:
https://doaj.org/article/a234cc3fadbb43ac865e2196a80d4551
Autor:
Hiroyuki Satofuka, Satoshi Abe, Takashi Moriwaki, Akane Okada, Kanako Kazuki, Hiroshi Tanaka, Kyotaro Yamazaki, Genki Hichiwa, Kayoko Morimoto, Haruka Takayama, Yuji Nakayama, Shinya Hatano, Yutaro Yada, Yasufumi Murakami, Yoshihiro Baba, Mitsuo Oshimura, Kazuma Tomizuka, Yasuhiro Kazuki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Trans-chromosomic (Tc) mice have helped the development of therapeutic antibodies, but chromosome instability limits its application. Here the authors develop a new line of Tc mice with full human Ig heavy and kappa loci integrated into the mouse art
Externí odkaz:
https://doaj.org/article/fb7ca36c22fa4c8995612d2e3884ca5e
Autor:
Kentaro Hata, Toyoshi Yanagihara, Keisuke Matsubara, Kazufumi Kunimura, Kunihiro Suzuki, Kazuya Tsubouchi, Daisuke Eto, Hiroyuki Ando, Maki Uehara, Satoshi Ikegame, Yoshihiro Baba, Yoshinori Fukui, Isamu Okamoto
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immune cells have been implicated in interstitial lung diseases (ILDs), although their phenotypes and effector mechanisms remain poorly understood. To better understand these cells, we conducted an exploratory mass cytometry analysis of immune cell s
Externí odkaz:
https://doaj.org/article/3f14ccfe44594d7d82573bf50619bd88
Publikováno v:
Electricity, Vol 2, Iss 2, Pp 158-167 (2021)
Electromagnetic fields and the heat of a metal oxide varistor (MOV), in which a lightning impulse current flows, are calculated using the finite-difference time-domain (FDTD) method. The MOV is represented with small rectangular parallelepiped cells,
Externí odkaz:
https://doaj.org/article/f8d5d595738849eea2c6826ae4319f64
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The Cre/loxP system is a powerful tool for generating conditional gene knockout (KO) mice and elucidate gene function in vivo. CD19-Cre and Mb1-iCre transgenic mice are commonly used for generating B cell-specific KO mice and investigate the
Externí odkaz:
https://doaj.org/article/c9d7f962546b4556b38d6cddb656c148
Autor:
Yuhsuke Ohmi, Wataru Ise, Akira Harazono, Daisuke Takakura, Hidehiro Fukuyama, Yoshihiro Baba, Masashi Narazaki, Hirofumi Shoda, Nobunori Takahashi, Yuki Ohkawa, Shuting Ji, Fumihiro Sugiyama, Keishi Fujio, Atsushi Kumanogoh, Kazuhiko Yamamoto, Nana Kawasaki, Tomohiro Kurosaki, Yoshimasa Takahashi, Koichi Furukawa
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Post-translational modifications, such as glycosylation and sialylation, are thought to confer disease modifying effects on autoimmune-associated antibodies, including anti-citrullinated protein antibodies in rheumatoid arthritis. Here the authors sh
Externí odkaz:
https://doaj.org/article/626de5323ebb454892d4e77327d0fdec
Autor:
Yukari Kondo, Shinichiro Higa, Takeshi Iwasaki, Tomoya Matsumoto, Kazumitsu Maehara, Akihito Harada, Yoshihiro Baba, Masatoshi Fujita, Yasuyuki Ohkawa
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191532 (2018)
The western blotting technique is widely used to analyze protein expression levels and protein molecular weight. The chemiluminescence method is mainly used for detection due to its high sensitivity and ease of manipulation, but it is unsuitable for
Externí odkaz:
https://doaj.org/article/5427a79502c640518d89367f5f234a60