Zobrazeno 1 - 10
of 375
pro vyhledávání: '"YOSHIHIKO FUJITA"'
Autor:
Koji Haratani, Hidetoshi Hayashi, Takayuki Takahama, Yasushi Nakamura, Shuta Tomida, Takeshi Yoshida, Yasutaka Chiba, Takahiro Sawada, Kazuko Sakai, Yoshihiko Fujita, Yosuke Togashi, Junko Tanizaki, Hisato Kawakami, Akihiko Ito, Kazuto Nishio, Kazuhiko Nakagawa
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Immune checkpoint inhibitors (ICIs) confer a survival benefit in many cancer types. Given that the survival outcome for cancer of unknown primary site (CUP) remains poor, we investigated the potential of CUP for immunotherapy. Met
Externí odkaz:
https://doaj.org/article/4c66ac95b41d4d21b4969c357886ab3f
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The construction of complex RNA-delivered genetic circuits in mammalian cells is challenging, though offers advantages over DNA circuits in clinical use. Here the authors construct a set of logic gates that respond to multiple miRNAs and demonstrate
Externí odkaz:
https://doaj.org/article/5d96f4d949ff47c3bc906effbfc044f5
Autor:
Hiromichi Matsuoka, Junji Tsurutani, Yasutaka Chiba, Yoshihiko Fujita, Masato Terashima, Takeshi Yoshida, Kiyohiro Sakai, Yoichi Otake, Atsuko Koyama, Kazuto Nishio, Kazuhiko Nakagawa
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-6 (2017)
Abstract Background Cancer patients experience pain that has physiological, sensory, affective, cognitive, behavioral, and sociocultural dimensions. Opioids are used in treatment of pain in patients with various types of cancer. We previously showed
Externí odkaz:
https://doaj.org/article/0bddda13045a4ec892a4dea1bb1c8e7f
Autor:
Tomonori Shibata, Yoshihiko Fujita, Hirohisa Ohno, Yuki Suzuki, Karin Hayashi, Kaoru R. Komatsu, Shunsuke Kawasaki, Kumi Hidaka, Shin Yonehara, Hiroshi Sugiyama, Masayuki Endo, Hirohide Saito
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nucleic acid nanotechnology has great potential for future therapeutic applications. Here the authors build protein-driven RNA nanostructures that can function within mammalian cells and regulate the cell fate.
Externí odkaz:
https://doaj.org/article/6fdff867a4114dc79b8f4e117a87c7ce
Autor:
Masato Chiba, Yosuke Togashi, Eri Bannno, Yoshihisa Kobayashi, Yu Nakamura, Hidetoshi Hayashi, Masato Terashima, Marco A. De Velasco, Kazuko Sakai, Yoshihiko Fujita, Tetsuya Mitsudomi, Kazuto Nishio
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background Non-small cell lung cancer (NSCLC) harboring common epidermal growth factor receptor (EGFR) gene mutations (exon 19 deletion or exon 21 L858R) respond to EGFR tyrosine kinase inhibitors (EGFR-TKIs). The secondary T790 M mutation i
Externí odkaz:
https://doaj.org/article/05b17bf231454e9ea7e937d72cd8a9cd
Autor:
Junya Akagi, Takahiro Yamada, Kumi Hidaka, Yoshihiko Fujita, Hirohide Saito, Hiroshi Sugiyama, Masayuki Endo, Shigeyoshi Matsumura, Yoshiya Ikawa
Publikováno v:
Applied Sciences, Vol 11, Iss 6, p 2583 (2021)
Ribozymes are catalytic RNAs that are attractive platforms for the construction of nanoscale objects with biological functions. We designed a dimeric form of the Tetrahymena group I ribozyme as a unit structure in which two ribozymes were connected i
Externí odkaz:
https://doaj.org/article/1c1b4df7047f471bab46324445d2f37b
Autor:
Miyuki Nemoto, Hiroyuki Sasai, Noriko Yabushita, Keito Tsuchiya, Kazushi Hotta, Yoshihiko Fujita, Taeho Kim, Takehiko Tsujimoto, Tetsuaki Arai, Kiyoji Tanaka
Publikováno v:
Geriatrics, Vol 5, Iss 2, p 29 (2020)
We aimed to develop a novel exercise to improve visuospatial ability and evaluate its feasibility and effectiveness in older adults with frailty. A non-randomized preliminary trial was conducted between June 2014 and March 2015. We recruited 35 adult
Externí odkaz:
https://doaj.org/article/54469a239a51494593fb5ac9bcddd234
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-2 (2019)
The original version of this Article contained an error in the fourth sentence of the second paragraph of the ‘Improving the performance of miRNA-responsive circuits’ section of the Results, which incorrectly read ‘We confirmed a significant fo
Externí odkaz:
https://doaj.org/article/7ad1e7a2d1da4b3da1f279097254f8ba
Autor:
Daisuke Tamura, Tokuzo Arao, Tomoyuki Nagai, Hiroyasu Kaneda, Keiichi Aomatsu, Yoshihiko Fujita, Kazuko Matsumoto, Marco A. DeVelasco, Hiroaki Kato, Hidetoshi Hayashi, Shuhei Yoshida, Hideharu Kimura, Yoshimasa Maniwa, Wataru Nishio, Yasuhiro Sakai, Chiho Ohbayashi, Yoshikazu Kotani, Yoshihiro Nishimura, Kazuto Nishio
Publikováno v:
Cancer Medicine, Vol 2, Iss 2, Pp 144-154 (2013)
Abstract Transcription factor Slug/SNAI2 (snail homolog 2) plays a key role in the induction of the epithelial mesenchymal transition in cancer cells; however, whether the overexpression of Slug mediates the malignant phenotype and alters drug sensit
Externí odkaz:
https://doaj.org/article/7a2bcae70ceb4d6aa10388d1dcd58260
Autor:
Kazuki Hara, Tatsuya Beppu, Masahiko Kimura, Yoshihiko Fujita, Toshikazu Takata, Kazuto Nishio, Nobufumi Ono
Publikováno v:
Journal of Pharmacological Sciences, Vol 122, Iss 2, Pp 153-157 (2013)
We studied the influence of novel supramolecular substance, [2] rotaxane (TRO-A0001), on caspase signaling and cell viability in cancer cell lines. TRO-A0001 suppressed concentration-dependently cell proliferation. Expression of the cleaved-form casp
Externí odkaz:
https://doaj.org/article/3c13724c1fdc4b74981cda38aff8d54e