Zobrazeno 1 - 10
of 177
pro vyhledávání: '"YONG-SU ZHEN"'
Autor:
Dan-dan Zhou, Xiao-tian Zhai, Lan-wen Zhang, Zi-hui Xie, Ying Wang, Yong-su Zhen, Rui-juan Gao, Qing-fang Miao
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-16 (2024)
Abstract Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new humanized anti-Trop2 antibody named hIMB1636, and designated it as an ideal targeting carrier
Externí odkaz:
https://doaj.org/article/866f250ded27490cb3efdaeecc640bc5
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 12, Iss 2, Pp 232-242 (2022)
Folate receptor (FR) overexpression occurs in a variety of cancers, including pancreatic cancer. In addition, enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer. Furthermore, the occurrence of intensive desmoplasia causes a hypoxic mi
Externí odkaz:
https://doaj.org/article/0d8c6a37e6cb405aa83581ab880b38c0
Autor:
Dan-Dan Zhou, Wei-Qi Bai, Xiao-Tian Zhai, Li-Ping Sun, Yong-Su Zhen, Zhuo-Rong Li, Qing-Fang Miao
Publikováno v:
Military Medical Research, Vol 8, Iss 1, Pp 1-14 (2021)
Abstract Background Triple-negative breast cancer (TNBC) is the most aggressive subtype and occurs in approximately 15–20% of diagnosed breast cancers. TNBC is characterized by its highly metastatic and recurrent features, as well as a lack of spec
Externí odkaz:
https://doaj.org/article/668db17c21a04120abadf7d0bc030eeb
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background Pancreatic cancer stem cells (CSCs), a special population of cells, renew themselves infinitely and resist to various treatment. Gramicidin A (GrA), an ionophore antibiotic derived from microorganism, can form channels across the
Externí odkaz:
https://doaj.org/article/22df4a9742f8447789baaea686c5d7c5
Autor:
Xin‐yue Hu, Rong Wang, Jie Jin, Xiu‐jun Liu, A‐long Cui, Lian‐qi Sun, Yan‐ping Li, Yi Li, Yu‐cheng Wang, Yong‐su Zhen, Qing‐fang Miao, Zhuo‐rong Li
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 246-263 (2019)
Epidermal growth factor receptor (EGFR) is a rational target for cancer therapy, because its overexpression plays an important oncogenic role in a variety of solid tumors; however, EGFR‐targeted antibody–drug conjugate (ADC) therapy for esophagea
Externí odkaz:
https://doaj.org/article/af0f3ad65cc842fdab36310b0d24bbdb
Autor:
Jian Xu, Yue Du, Wen-Juan Liu, Liang Li, Yi Li, Xiao-Fei Wang, Hong-Fei Yi, Chuan-Kun Shan, Gui-Min Xia, Xiu-Jun Liu, Yong-Su Zhen
Publikováno v:
Drug Delivery, Vol 25, Iss 1, Pp 102-111 (2018)
Fibrosarcomas are highly aggressive malignant tumors. It is urgently needed to explore targeted drugs and modalities for more effective therapy. Matrix metalloproteinases (MMPs) play important roles in tumor progression and metastasis, while several
Externí odkaz:
https://doaj.org/article/ba03ae06f8364dd2bcbe85971bd7803e
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92986 (2014)
Esophageal cancer is one of the most common cancers, and the 5-year survival rate is less than 10% due to lack of effective therapeutic agents. This study was to evaluate antitumor activity of Ec-LDP-Hr-AE, a recently developed bispecific enediyne-en
Externí odkaz:
https://doaj.org/article/6600505bb0314968889b60bd5f6d6f24
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115790 (2014)
The tumor microenvironment plays a crucial role during tumor development. Integrated combination of drugs that target tumor microenvironment is a promising approach to anticancer therapy. Here, we report a multifunctional combination of low-cytotoxic
Externí odkaz:
https://doaj.org/article/5edf68cb903047a5bed350266b8b9fa6
Publikováno v:
Ibrain, Vol 10, Iss 4, Pp 542-546 (2024)
Abstract A 48‐year‐old female patient was hospitalized for 5 days after a cold. Encephalitis was considered after preliminary history and routine examination, but the patient did not show significant improvement after antiviral treatment. At this
Externí odkaz:
https://doaj.org/article/b8d68ae2b26246edb310d10ebde5afe3
Purpose: The cooverexpression of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) observed in many human tumors and their synergistic interaction in the transformation of cells make these receptors important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b56b917d31ee7c00b2f6c27cde9ff5
https://doi.org/10.1158/1078-0432.c.6518901
https://doi.org/10.1158/1078-0432.c.6518901
