Zobrazeno 1 - 10
of 82
pro vyhledávání: '"YING-LAN ZHAO"'
Autor:
Pu Xiang, Hui Jie, Yang Zhou, Bo Yang, Hui-Juan Wang, Jing Hu, Jian Hu, Sheng-Yong Yang, Ying-Lan Zhao
Publikováno v:
Molecules, Vol 20, Iss 5, Pp 7620-7636 (2015)
A series of quinoline derivatives was synthesized and biologically evaluated as Enhancer of Zeste Homologue 2 (EZH2) inhibitors. Structure-activity relationship (SAR) studies led to the discovery of 5-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methy
Externí odkaz:
https://doaj.org/article/e26056293226466cbdfe99fb0d07c202
Autor:
Liang Wang, Xiaojie Wang, Chunqi Liu, Wei Xu, Weihong Kuang, Qian Bu, Hongchun Li, Ying Zhao, Linhong Jiang, Yaxing Chen, Feng Qin, Shu Li, Qingfan Wei, Xiaocong Liu, Rong Chen, Yumam He, Yonghai Wang, Bin Liu, Yuanyuan Chen, Yanping Dai, Hongbo Wang, Jingwei Tian, Ying-lan Zhao, Xiaobo Cen
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::085093de87462532c4957c669a928af2
https://doi.org/10.2139/ssrn.4117925
https://doi.org/10.2139/ssrn.4117925
Autor:
Yan-Ni Lin, Hua-Cheng Yang, Wei-Yi Pi, Zi-Cheng Li, Ying-Lan Zhao, You-Fu Luo, Yuquan Wei, Ying-Hong Yang, Jian-Zhong Yang, Hong He, Wei Ang, Tao Yang
Publikováno v:
Molecules, Vol 17, Iss 3, Pp 2351-2366 (2012)
A series of N-3-substituted 7-aminopyrido[2,3-d]pyrimidin-6-carbonitrile derivatives was readily synthesized and their anti-proliferative activities on five types of tumor cells were evaluated through a cell-based phenotypic screening approach. Compo
Externí odkaz:
https://doaj.org/article/4cbfda61eda5489680a88b6f294ae772
Publikováno v:
Molecules, Vol 17, Iss 1, Pp 873-883 (2012)
In a previous hit-to-lead research program targeting anticancer agents, two promising lead compounds, 1a and 1b, were found. However, the poor solubility of 1a and 1b made difficult further in vivo studies. To solve this problem, a lead optimization
Externí odkaz:
https://doaj.org/article/d4bd9106aafb4b3a9d2be2c9728c1de5
Publikováno v:
Molecules, Vol 16, Iss 12, Pp 10685-10694 (2011)
In a cell-based screen of novel anticancer agents, the hit compound 1a which bears a pyrazolo[3,4-d]pyrimidine scaffold exhibited high inhibitory activity against a panel of four different types of tumor cell lines. In particular, the IC50 for A549 c
Externí odkaz:
https://doaj.org/article/e9ad016624c6436fa46ada0d2295ef24
Publikováno v:
Molecules, Vol 16, Iss 3, Pp 2519-2526 (2011)
Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by 1H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lun
Externí odkaz:
https://doaj.org/article/1b5c5e1335c744a5979766943eaca1f1
Publikováno v:
Molecules, Vol 15, Iss 12, Pp 9473-9485 (2010)
In our ongoing research on novel anticancer agents with 4-anilinoquinazoline scaffolds, a series of novel 2-chloromethyl-4(3H)-quinazolinones were needed as key intermediates. An improved one-step synthesis of 2-chloromethyl-4(3H)-quinazolinones util
Externí odkaz:
https://doaj.org/article/05032e87b59748978d4923a405f85735
Autor:
Yi Dan Zhou, Qiao Li, Xia Zhou, Gang Yu, Ying Lan Zhao, Yushan Ren, Xiao-Lian Zhang, Hai Dan Chen
Publikováno v:
Journal of Clinical Immunology. 32:820-836
Core 1 beta 1,3-galactosyltransferase also known as T-antigen-synthase or T-synthase is a key enzyme for the synthesis of the common core 1 O-glycan structure (T-antigen). Although T-synthase is known to be important in human immune-related diseases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf55061d4bbd31fbf5a52b0aa88fc8b
https://doi.org/10.1007/s10875-012-9653-8
https://doi.org/10.1007/s10875-012-9653-8
Autor:
Yang He, Cheng Xu, Wen Huang, Yu Quan Wei, Zhi Hua Xing, Qingyi Tong, Xiao Hua Wu, Ying Lan Zhao, Shi Yuan Zhang, Dan Shu, Yi Li, Yong Qing, Zhen Ling Wang
Publikováno v:
Cellular Physiology and Biochemistry. 27:233-242
Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis Wright (DZW), has shown high-cytotoxic activity in cancer cells. However, its mechanisms and in vivo anti-cancer effects remain unknown. In the present study, we evaluated the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b227871748039ae29c1c6742b1defd9
https://doi.org/10.1159/000327949
https://doi.org/10.1159/000327949
Autor:
Shi‑Sheng Tan, Si‑Ying Wang, Yan Li, Youzhi Xu, Man‑Li Li, Yong‑Huai Li, Ying‑Lan Zhao, Tian‑Ming Wu, Hong‑Jun Lin, Wen‑Jie Lu
Publikováno v:
Oncology Letters
Sunitinib based adjuvant chemotherapy combined with chloroquine (CQ) for the treatment of renal cell carcinoma (RCC) is in clinical trials; however, its anti-RCC effect and the mechanism remain unclear. In the present study, the anti-RCC effect of su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2cc341c70820110a8f16fcb301ab37c
https://pubmed.ncbi.nlm.nih.gov/29435010
https://pubmed.ncbi.nlm.nih.gov/29435010