Zobrazeno 1 - 10
of 1 432
pro vyhledávání: '"YI Le"'
Publikováno v:
Cell Division, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract Purpose Cervical cancer (CC), a significant global health threat, necessitates comprehensive understanding for improved therapeutic interventions. Many research indicates that dysregulation of the Hippo-YAP1 pathway leads to uncontrolled pro
Externí odkaz:
https://doaj.org/article/4588a9890bb04ddfa39ac1ae8258ca9e
Autor:
Min Zhong, Zhi Fang, Juntao Zou, Xiao Chen, Zezhi Qiu, Ling Zhou, Yi Le, Zhen Chen, Yanyu Liao, Fengting Nie, Xianpin Wei, Jinbo Zhan, Jianping Xiong, Xiaojun Xiang, Ziling Fang
Publikováno v:
Cell Death and Disease, Vol 15, Iss 11, Pp 1-15 (2024)
Abstract Despite the importance of radiation therapy as a nonsurgical treatment for non-small cell lung cancer (NSCLC), radiation resistance has always been a concern because of poor patient response and outcomes. Therefore, it is crucial to identify
Externí odkaz:
https://doaj.org/article/0e21cb74e77f4987806097cf4a7b6223
Publikováno v:
Frontiers in Earth Science, Vol 12 (2024)
This study delves into the design and deformation patterns of support structures in urban deep excavation projects, aiming to optimize the design of these structures to ensure their safety and stability. Initially, experimental research on steel-ceme
Externí odkaz:
https://doaj.org/article/fe4f5e7c66d644d6b8629a113a5f8e4e
Autor:
Jinbo Zhan, Ling Zhou, Hongjiao Zhang, Juanjuan Zhou, Yan He, Tingting Hu, Yi Le, Yun Lin, Jingru Wang, Haiming Yu, Yawen Liu, Xiaojun Xiang
Publikováno v:
Translational Oncology, Vol 40, Iss , Pp 101843- (2024)
Previous studies have demonstrated that carbohydrate sulfotransferase family proteins (CHSTs) play a crucial role in the extracellular matrix structural constituent and cancer progression, however, the effect of CHSTs on gastric cancer is still super
Externí odkaz:
https://doaj.org/article/f07e4fb084d147d7ba999e12ad70f85c
Autor:
Qiming Wu, Juntao Kan, Caili Fu, Xin Liu, Zhengying Cui, Sixu Wang, Yi Le, Zhanming Li, Qin Liu, Yuyu Zhang, Jun Du
Publikováno v:
Current Research in Microbial Sciences, Vol 7, Iss , Pp 100301- (2024)
Extracellular vesicles (EVs), which play significant regulatory roles in maintaining homeostasis and influencing immune responses, significantly impact gut microbiota composition and function, affecting overall gut health. Despite considerable progre
Externí odkaz:
https://doaj.org/article/b9b29530eaac449eabbbd08162cfaa9d
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108731- (2024)
Summary: Immune suppression within tumor microenvironments (TME) have been implicated in limited efficacy of immune check point inhibitors (ICIs) against solid tumors. Down-regulated VentX expression in tumor associated macrophages (TAMs) underlies p
Externí odkaz:
https://doaj.org/article/ba52bae135fe42ffa501c894e4157e21
Autor:
Jianping Zou, Ling Zhou, Yi Le, Zhi Fang, Min Zhong, Fengting Nie, Xianpin Wei, Xiaomei Zhang, Zhen Chen, Lingling Cai, Heng Wang, Jianping Xiong, Ziling Fang, Xiaojun Xiang
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Large tumor suppressor kinase 1 (LATS1), one of the predominant components of the Hippo pathway, has been characterized as a key player controlling the proliferation and invasion of cancer cells, including gastric cancer (GC) cell
Externí odkaz:
https://doaj.org/article/512249fa4b1f41c4afea0672c47ba676
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 832-843 (2022)
This paper described our efforts to develop dianilinopyrimidines as novel EGFR inhibitors. All the target compounds were tested for inhibitory effects against wild type EGFR (EGFRwt) and three tumour cells, including A549, PC-3, and HepG2. Some of th
Externí odkaz:
https://doaj.org/article/3ea05789c26d4e8398a323105a2dc5df
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2742-2754 (2022)
A new series of 5-trifluoromethylpyrimidine derivatives were designed and synthesised as EGFR inhibitors. Three tumour cells A549, MCF-7, PC-3 and EGFR kinase were employed to evaluate their biological activities. The results were shown that most of
Externí odkaz:
https://doaj.org/article/73071dcf92cd4afd9bd84c30769639ef
Autor:
Qiming Wu, Yuchen Ma, Lanxin Zhang, Jing Han, Yanan Lei, Yi Le, Caoxing Huang, Juntao Kan, Caili Fu
Publikováno v:
Current Research in Food Science, Vol 7, Iss , Pp 100621- (2023)
Chlorella pyrenoidosa (C. pyrenoidosa) has been widely used in commercial food and feed production for numerous years. Its high protein content and cost-effectiveness make it an attractive source of novel protein. With a focus on sustainable developm
Externí odkaz:
https://doaj.org/article/ee61827c396741208fb0740f750d6355