A short survey of dengue protease inhibitor development in the past 6 years (2015-2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases

Autor: Deepak Shilkar, Venkatesan Jayaprakash, Biswatrish Sarkar, Barij Nayan Sinha, Sheikh Murtuja

Publikováno v: Bioorganic & Medicinal Chemistry

Dengue remains a disease of significant concern, responsible for nearly half of all arthropod-borne disease cases across the globe. Due to the lack of potent and targeted therapeutics, palliative treatment and the adoption of preventive measures rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a675c4389f51048f534e368db1d9f9d4
https://pubmed.ncbi.nlm.nih.gov/34601454

ADE and hyperinflammation in SARS-CoV2 infection- comparison with dengue hemorrhagic fever and feline infectious peritonitis

Autor: Sheela Ramanathan, Maryse Cloutier, Hugues Allard Chamard, Subburaj Ilangumaran, Awais Ullah Ihsan, Madhuparna Nandi

Publikováno v: Cytokine

Highlights • ADE increases viraemia in DHF and in FCoV infections. • In SARS-CoV infections ADE promotes inflammation. • The underlying cause of hyperinflammation is not clear in Covid-19.
The COVID-19 pandemic has rapidly spread around th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d226be9d01101171f0fdabcb3c235775
https://doi.org/10.1016/j.cyto.2020.155256

Neurons under viral attack: Victims or warriors?

Autor: Anirban Basu, Kallol Dutta, Swarupa Chakraborty, Arshed Nazmi

Publikováno v: Neurochemistry International

When the central nervous system (CNS) is under viral attack, defensive antiviral responses must necessarily arise from the CNS itself to rapidly and efficiently curb infections with minimal collateral damage to the sensitive, specialized and non-rege

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f477ebf1739590649d0c5f85af1a58c7
http://europepmc.org/articles/PMC7115389

The interferon response circuit: Induction and suppression by pathogenic viruses

Autor: Georg Kochs, Otto Haller, Friedemann Weber

Publikováno v: Virology

Type I interferons (IFN-α/β) are potent antiviral cytokines and modulators of the adaptive immune system. They are induced by viral infection or by double-stranded RNA (dsRNA), a by-product of viral replication, and lead to the production of a broa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3283a51818c1b9c5540c0020507b0cfd

Human Alkhumra hemorrhagic Fever: Emergence, history and epidemiological and clinical profiles.

Autor: Abdulhaq AA; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia.; Deanship of Scientific Research, Jazan University, Jazan, Kingdom of Saudi Arabia.; Vector-Borne Diseases Research Group, Jazan University, Jazan, Kingdom of Saudi Arabia., Hershan AA; Department of Medical Microbiology and Parasitology, Faculty of Medicine, University of Jeddah, Jeddah, Kingdom of Saudi Arabia.; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Jeddah, Jeddah, Kingdom of Saudi Arabia., Karunamoorthi K; Vector-Borne Diseases Research Group, Jazan University, Jazan, Kingdom of Saudi Arabia.; Department of Epidemiology, Faculty of Public Health and Tropical Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia., Al-Mekhlafi HM; Vector-Borne Diseases Research Group, Jazan University, Jazan, Kingdom of Saudi Arabia.; Medical Research Center, Jazan University, Jazan, Kingdom of Saudi Arabia.; Department of Parasitology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.

Publikováno v: Saudi journal of biological sciences [Saudi J Biol Sci] 2022 Mar; Vol. 29 (3), pp. 1900-1910. Date of Electronic Publication: 2021 Oct 22.