Výsledky vyhledávání - "YEŞİM ÖZKAN"

Akademický článek

Retinal Ganglion Cell Protection Via Topical and Systemic Alpha-Tocopherol Administration in Optic Nerve Crush Model of Rat

Autor: Zeynep Aktaş, Cüneyt Özmen, Pinar Göçün, Zelihagül Değim, Yeşim Özkan, Merih Onol

Publikováno v: Türk Oftalmoloji Dergisi, Vol 43, Iss 3, Pp 161-166 (2013)

Pur po se: The aim of our study was to investigate the neuroprotective effects of topical α-tocopherol in optic nerve crush model of rat and to compare its efficacy with that of systemic α -tocopherol. Ma te ri al and Met hod: 50 eyes of 25 Wista

Externí odkaz: https://doaj.org/article/6c09e4d1d6f142a0989fb2b8a2857b3b

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The potential of 4-aryl-6-morpholino-3(2H)-pyridazinone-2-arylpiperazinylacetamide as a new scaffold for SIRT2 inhibition: in silico approach guided by pharmacophore mapping and molecular docking

Autor: Yeşim Özkan, Murat Sukuroglu, Gokcen Eren, Mahmut Gozelle

Numerous studies have demonstrated that the aberrant enzymatic activity of SIRTs has been linked to various diseases like diabetes, cancer, inflammation, cardiovascular diseases, neurodegenerative disorders and therefore, the modulation of SIRTs is o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3a8bb0d4ca4acb1e93b1eb5afdc66d
https://avesis.gazi.edu.tr/publication/details/37c47753-e89c-4d81-a33d-fb5ab650a89d/oai

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Hit-to-lead optimization on aryloxybenzamide derivative virtual screening hit against SIRT

Autor: Filiz Bakar-Ates, Ahmet Bugra Aksel, Gokcen Eren, Semih Yagci, Yasemin Dündar, Mahmut Gozelle, Selen Gozde Kaya, Yeşim Özkan

Publikováno v: Bioorganicmedicinal chemistry. 30

Sirtuins (SIRTs) are a class of nicotinamide adenine dinucleotide (NAD+)-dependent protein histone deacetylases (HDACs) that are evolutionarily conserved from bacteria to mammals. This group of enzymes catalyses the reversible deacetylation of lysine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214c6e08deccf90279d3adf4ab482f72
https://pubmed.ncbi.nlm.nih.gov/33360574

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Microwave-assisted synthesis and pharmacological screening of some triazolothiadiazole derivatives

Autor: Kevser Erol, Yeşim Özkan, Tijen Önkol, Bilge Çakir, Engin Yildirim, Ozge Gorgu

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 56 (2020)
Brazilian Journal of Pharmaceutical Sciences, Volume: 56, Article number: e18111, Published: 16 MAR 2020
Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18111
Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18111
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP

In this study, twenty-two new [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (5a-n, 6a-h) were synthesized under microwave irradiation (MWI). The chemical structures of the compounds were elucidated by their IR, 1 H-NMR, LC-MS, and elemental analysis. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cd1815c1ee68a851e07779b11b6232
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100526&tlng=en

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Determination of Tryptophan and Kynurenine by LC-MS/MS by Using Amlodipine as an Internal Standard

Autor: Aylin Sepici Dinçel, Burcu Eser, Yeşim Özkan

Tryptophan is an essential amino acid that plays an important role in cell metabolism, and kynurenine is its main metabolic pathway. By using ultra-high-performance liquid chromatography coupled to electrospray ionization triple-quadrupole mass spect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42aaabd23aba6506398a2acaa782fd76
https://avesis.gazi.edu.tr/publication/details/103a3b69-afcb-4256-b5e4-411657a44165/oai

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Identification Of Small-Molecule Urea Derivatives As Novel Nampt Inhibitors Via Pharmacophore-Based Virtual Screening

Autor: Fikriye Ozgencil, Yeşim Özkan, Sezen Guntekin-Ergun, Gokcen Eren, Rengul Cetin-Atalay

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the condensation of nicotinamide (NAM) with 5-phosphoribosyl-1-prophosphate (PRPP) to yield nicotinamide mononucleotide (NMN), a rate limiting enzyme in a mammalian salvage pathway of nicotinam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decebf7a42ec019ac0363ac473aa5f2a
https://aperta.ulakbim.gov.tr/record/5815

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Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors

Autor: Selen Gozde Kaya, Mahmut Gozelle, Gokcen Eren, Rengul Cetin-Atalay, Agostino Bruno, Sezen Guntekin-Ergun, Gabriele Costantino, Yeşim Özkan, Fikriye Ozgencil

Sirtuins (SIRTs) are a class of NAD(+)-dependent protein histone deacetylases (HDACs) that catalyse the reversible deacetylation of lysine residues in the histones or non-histone substrates. Mammalian sirtuins consist of seven isoforms (SIRT1-7), whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9790623b37409cbc58b3b3f6bb71d34f
https://avesis.gazi.edu.tr/publication/details/4a26d71b-a9cf-492e-8ab6-24edd78bc9ba/oai

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Design, synthesis and biological evaluation of novel 1,3-diarylpyrazoles as cyclooxygenase inhibitors, antiplatelet and anticancer agents

Autor: Rengul Cetin-Atalay, Sultan Nacak Baytas, Nazan Inceler, Deniz Cansen Kahraman, Nilüfer N. Turan, Yeşim Özkan

With the aim of achieving new compounds possessing both anti-inflammatory and antiplatelet activities, we synthesized (E)-3-[3-(pyridin-3/4-yl)-1-(phenyl/sulfonylmethylphenyl)-1H-pyrazol-4-yl]acrylamides, and evaluated their COX-1 and COX-2 inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4968113d94c45b940a62d938d2437b67
https://avesis.gazi.edu.tr/publication/details/df0bd09b-b3eb-4c1e-9fca-3912b3585b1b/oai

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Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients

Autor: Hakan Özsoy, Murat Şüküroğlu, Aylin Sepici Dinçel, Ercan Dinçel, Yeşim Özkan

Objectives This study aims to evaluate tryptophan degradation and clarify whether altered levels of kynurenine and tryptophan (Kyn/Trp) ratio could be correlated to osteoporotic hip fractures via immune system. Patients and methods The study included

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425e5a6125041519ec291ab88940d733
https://europepmc.org/articles/PMC6190949/

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Association of obstructive sleep apnea with homocystein, nitric oxide and total antioxidant capacity levels in patients with or without coronary artery disease

Autor: Yeşim Özkan, Recai Ergün, Hikmet Firat, Sadik Ardic, Sevgi Akaydin, Mine Durusu, Gülbahar Darılmaz Yüce, Arzu Topeli, Ebru Ortaç Ersoy

Publikováno v: Tuberk Toraks. 62:207-214

INTRODUCTION: Obstructive sleep apnea (OSA) is associated with cardiovascular morbidity and mortality. Deficiency of nitric oxide (NO) and plasma levels of homocystein have been implicated in the pathogenesis of cardiovascular disease. OSA results in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd4f1ce1b5a4395a12a62690ead21d1
https://doi.org/10.5578/tt.7845

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