Výsledky vyhledávání - "YASUJIRO KIYOTA"

Akademický článek

Automated algorithm development to assess survival of human neurons using longitudinal single-cell tracking: Application to synucleinopathy

Autor: Jeonghoon Choi, Hiroaki Kii, Justin Nelson, Yoichi Yamazaki, Fumiki Yanagawa, Atsushi Kitajima, Takayuki Uozumi, Yasujiro Kiyota, Dimple Doshi, Kenneth Rhodes, Robert Scannevin, Heather Sadlish, Chee Yeun Chung

Publikováno v: SLAS Technology, Vol 28, Iss 2, Pp 63-69 (2023)

The development of phenotypic assays with appropriate analyses is an important step in the drug discovery process. Assays using induced pluripotent stem cell (iPSC)-derived human neurons are emerging as powerful tools for drug discovery in neurologic

Externí odkaz: https://doaj.org/article/718216d2882f4578a15d3fa8eb3f2afb

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Akademický článek

Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons

Autor: Tim Ahfeldt, Alban Ordureau, Christina Bell, Lily Sarrafha, Chicheng Sun, Silvia Piccinotti, Tobias Grass, Gustavo M. Parfitt, Joao A. Paulo, Fumiki Yanagawa, Takayuki Uozumi, Yasujiro Kiyota, J. Wade Harper, Lee L. Rubin

Publikováno v: Stem Cell Reports, Vol 14, Iss 1, Pp 75-90 (2020)

Summary: Parkinson's disease (PD) is a complex and highly variable neurodegenerative disease. Familial PD is caused by mutations in several genes with diverse and mostly unknown functions. It is unclear how dysregulation of these genes results in the

Externí odkaz: https://doaj.org/article/1a013adc4b7343d58d3ed3b490fa2fb1

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Akademický článek

Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

Publikováno v: Cell Reports, Vol 21, Iss 10, Pp 2661-2670 (2017)

Summary: Organoid technology provides a revolutionary paradigm toward therapy but has yet to be applied in humans, mainly because of reproducibility and scalability challenges. Here, we overcome these limitations by evolving a scalable organ bud prod

Externí odkaz: https://doaj.org/article/a82cbaeac6e0480a92f03b989a1e317e

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Akademický článek

Visualization of morphological categories of colonies for monitoring of effect on induced pluripotent stem cell culture status

Autor: Risako Nagasaka, Megumi Matsumoto, Mai Okada, Hiroto Sasaki, Kei Kanie, Hiroaki Kii, Takayuki Uozumi, Yasujiro Kiyota, Hiroyuki Honda, Ryuji Kato

Publikováno v: Regenerative Therapy, Vol 6, Iss C, Pp 41-51 (2017)

From the recent advances, there are growing expectations toward the mass production of induced pluripotent stem cells (iPSCs) for varieties of applications. For such type of industrial cell manufacturing, the technology which can stabilize the produc

Externí odkaz: https://doaj.org/article/f474e127784e4b488cdb2eceab66ecac

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Akademický článek

Label-free morphology-based prediction of multiple differentiation potentials of human mesenchymal stem cells for early evaluation of intact cells.

Autor: Hiroto Sasaki, Ichiro Takeuchi, Mai Okada, Rumi Sawada, Kei Kanie, Yasujiro Kiyota, Hiroyuki Honda, Ryuji Kato

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93952 (2014)

Precise quantification of cellular potential of stem cells, such as human bone marrow-derived mesenchymal stem cells (hBMSCs), is important for achieving stable and effective outcomes in clinical stem cell therapy. Here, we report a method for image-

Externí odkaz: https://doaj.org/article/0a311d41311e49eb8babced2ffd86b9b

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Akademický článek

Morphology-based prediction of osteogenic differentiation potential of human mesenchymal stem cells.

Autor: Fumiko Matsuoka, Ichiro Takeuchi, Hideki Agata, Hideaki Kagami, Hirofumi Shiono, Yasujiro Kiyota, Hiroyuki Honda, Ryuji Kato

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55082 (2013)

Human bone marrow mesenchymal stem cells (hBMSCs) are widely used cell source for clinical bone regeneration. Achieving the greatest therapeutic effect is dependent on the osteogenic differentiation potential of the stem cells to be implanted. Howeve

Externí odkaz: https://doaj.org/article/debde22a24c44fd5894fe617b9c9cb5d

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