Zobrazeno 1 - 10
of 2 414
pro vyhledávání: '"YAP/TAZ"'
Publikováno v:
FEBS Open Bio, Vol 14, Iss 11, Pp 1914-1925 (2024)
To improve the translation of preclinical cancer research data to successful clinical effect, there is an increasing focus on the use of primary patient‐derived cancer cells with limited growth in culture to reduce genetic and phenotype drift. Howe
Externí odkaz:
https://doaj.org/article/d97b5a43def148049640c55602ec9a9d
Autor:
Juanjuan Han, Jiale Zhang, Xiaoyi Zhang, Wenxin Luo, Lifei Liu, Yuqing Zhu, Qingfeng Liu, Xin-an Zhang
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Hippo pathway is an evolutionarily conservative key pathway that regulates organ size and tissue regeneration by regulating cell proliferation, differentiation and apoptosis. Yes-associated protein 1 (YAP)/ WW domain-containing transcription
Externí odkaz:
https://doaj.org/article/fab4ac2379974eeda29bbc0a8a44a16b
Autor:
Muthu Thiruvengadan
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 1023-1026 (2024)
Externí odkaz:
https://doaj.org/article/81335ad420cb42c197331bfd00fcf882
Autor:
Yina Wang, Liangyou Rui
Publikováno v:
Onco, Vol 4, Iss 3, Pp 217-231 (2024)
Liver cancer imposes a pervasive global health challenge, ranking among the most prevalent cancers worldwide. Its prevalence and mortality rates are on a concerning upward trajectory and exacerbated by the dearth of efficacious treatment options. The
Externí odkaz:
https://doaj.org/article/c60e0ebbb9a340b3864bbeccea72390e
Autor:
Lili Li, Zhenghao Shi, Yuxuan Li, Jiacheng Xu, Shuchen Han, Jinyan Chen, Hanyang Xu, Jiemei Jiang, Yan Yang, Yongfang Gong
Publikováno v:
Journal of Functional Foods, Vol 122, Iss , Pp 106553- (2024)
Salvianolic acid B (Sal B) is a natural compound extracted from the root of Salvia miltiorrhiza, which has multiple biological activities. Targeting Hippo pathway transcriptional coactivators YAP/TAZ combined with Smad3 is an effective strategy again
Externí odkaz:
https://doaj.org/article/3da017e3bb674b0facbcc3863155aa2b
Autor:
Youjia Yu, Chunyan Chu, Kang Wang, Yan Li, Zhengsheng Mao, Li Hu, Jie Wang, Yanfang Yu, Hao Sun, Feng Chen
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Paraquat (PQ) is a widely used herbicide and a common cause of poisoning that leads to pulmonary fibrosis with a high mortality rate. However, the underlying mechanisms of PQ-induced pulmonary fibrosis and whether pulmonary epithelial cell s
Externí odkaz:
https://doaj.org/article/a84bc55fbd5c4480a5ef8d2937579790
Autor:
Marie Tollot-Wegner, Marco Jessen, KyungMok Kim, Adrián Sanz-Moreno, Nadine Spielmann, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, Björn von Eyss
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-17 (2024)
Abstract The transcription factor TRPS1 is a context-dependent oncogene in breast cancer. In the mammary gland, TRPS1 activity is restricted to the luminal population and is critical during puberty and pregnancy. Its function in the resting state rem
Externí odkaz:
https://doaj.org/article/33d6128e83e04f16972355b82fbacb9d
Autor:
Rakibul Islam, Zhongkui Hong
Publikováno v:
Mechanobiology in Medicine, Vol 2, Iss 4, Pp 100085- (2024)
Cardiovascular diseases (CVDs) persistently rank as a leading cause of premature death and illness worldwide. The Hippo signaling pathway, known for its highly conserved nature and integral role in regulating organ size, tissue homeostasis, and stem
Externí odkaz:
https://doaj.org/article/097e9fcbb2b046eaa747a050f5465948
Akademický článek
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Publikováno v:
Royal Society Open Science, Vol 11, Iss 8 (2024)
Advanced in vitro culture systems have emerged as alternatives to animal testing and traditional cell culture methods in biomedical research. Polydimethylsiloxane (PDMS) is frequently used in creating sophisticated culture devices owing to its elasto
Externí odkaz:
https://doaj.org/article/be2372e881d74bca89e4e4e295422e1d