Zobrazeno 1 - 10
of 52
pro vyhledávání: '"YANSUI LI"'
Autor:
Randy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa Siddiq, Prashant Rajbhandari, Andrew F. Stewart, Donald K. Scott, Adolfo Garcia-Ocana, Geming Lu
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background Single-cell RNA sequencing (scRNA-seq) provides valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that complicates its utility
Externí odkaz:
https://doaj.org/article/16b1eb06924e409ea8786e29877b0d8e
Autor:
Julian K. Horwitz, Sofia Bin, Robert L. Fairchild, Karen S. Keslar, Zhengzi Yi, Weijia Zhang, Vasile I. Pavlov, Yansui Li, Joren C. Madsen, Paolo Cravedi, Peter S. Heeger
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Erythropoietin (EPO) has multiple nonerythropoietic functions, including immune modulation, but EPO’s effects in transplantation remain incompletely understood. We tested the mechanisms linking EPO administration to prolongation of murine heterotop
Externí odkaz:
https://doaj.org/article/1b0271f84e3245dda23663c661913691
Autor:
Nicholas Chun, Rosalind L. Ang, Mark Chan, Robert L. Fairchild, William M. Baldwin III, Julian K. Horwitz, Jesse D. Gelles, Jerry Edward Chipuk, Michelle A. Kelliher, Vasile I. Pavlov, Yansui Li, Dirk Homann, Peter S. Heeger, Adrian T. Ting
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
TNF ligation of TNF receptor 1 (TNFR1) promotes either inflammation and cell survival by (a) inhibiting RIPK1’s death-signaling function and activating NF-κB or (b) causing RIPK1 to associate with the death-inducing signaling complex to initiate a
Externí odkaz:
https://doaj.org/article/1cef15809b5044ec872dc4819293a566
Publikováno v:
Diabetes. 71
Single-cell RNA sequencing (scRNA-seq) of human islets requires cell dissociation and does not provide information on the transcriptional status of islet cells. On the other hand, single-nucleus RNA sequencing (snRNA-seq) does not require cell dissoc
Autor:
KARA A. BELIARD, CAROLINA ROSSELOT, YANSUI LI, ALEXANDRA ALVARSSON, PENG WANG, KEYA THAKKAR, DANIELA GUEVARA, ROBERT J. DEVITA, ANDREW F. STEWART, SARAH STANLEY, ADOLFO GARCIA-OCANA
Publikováno v:
Diabetes. 71
Diabetes results from diminished functional β-cell mass. Small molecule inhibitors of Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) markedly increase human β-cell replication in vitro and in vivo. Furthermore, combination o
Autor:
CAROLINA ROSSELOT, YANSUI LI, DANIELA GUEVARA, KARA A. BELIARD, RANDY KANG, PENG WANG, KEYA THAKKAR, GEMING LU, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA
Publikováno v:
Diabetes. 71
GLP1R agonists such as Exendin-4 (E) together with DYRK1A inhibitors such as Harmine (H) significantly increase human β-cell replication in vitro and in vivo. Importantly, 3-month treatment with H+E combination markedly increases human beta cell mas
Autor:
GEMING LU, RANDY KANG, YANSUI LI, PENG WANG, CAROLINA ROSSELOT, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA
Publikováno v:
Diabetes. 71
Type 1 diabetes (T1D) results from loss of both immune tolerance and functional β-cells. Administration of harmine (H) plus exendin-4 (E) markedly induces human β-cell expansion. Anti-CD3 antibody treatment reduces C-peptide loss in T1D patients. H
Autor:
Randy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa Siddiq, Prashant Rajbhandari, Andrew F. Stewart, Donald K. Scott, Adolfo Garcia-Ocana, Geming Lu
Single-cell RNA sequencing (scRNA-seq) has provided valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that complicates its utility in vivo and prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f987db34a5ec4d398a3bbd9d0048a5c
https://doi.org/10.1101/2022.05.22.492974
https://doi.org/10.1101/2022.05.22.492974
Autor:
Sharon Baumel-Alterzon, Liora S. Katz, Gabriel Brill, Clairete Jean-Pierre, Yansui Li, Isabelle Tse, Shyam Biswal, Adolfo Garcia-Ocaña, Donald K. Scott
Publikováno v:
Diabetes
Finding therapies that can protect and expand functional b-cell mass is a major goal of diabetes research. Here we generated b-cell-specific conditional knockout and gain-of-function mouse models and used human islet transplant experiments to examine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da41fa7e828d313c51c0f5228434df2
https://europepmc.org/articles/PMC9044139/
https://europepmc.org/articles/PMC9044139/
Autor:
Phillip D. Levy, Farhan Chaudhry, Jinhua Liu, Hideki Kawai, Peter S. Heeger, Jeffrey A. Mattis, Navneet Narula, Matthew K.M.Y. Adapoe, Andre L. Moreira, Aditya Shekhar, Yansui Li, Kipp W. Johnson, H. William Strauss, Jagat Narula, Koon Y. Pak, Julian K. Horwitz, Artiom Petrov
Publikováno v:
JACC: Cardiovascular Imaging. 13:1438-1441
About 5,400 heart transplantations are performed around the world annually. Survival in allograft recipients has improved substantially over the years with effective immunosuppressive therapy. However, acute cellular or antibody-mediated allograft re