Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Y.V. Rama Prasad"'
Autor:
Yukako Yoshikawa, Takashi Minamimoto, Saori Mori, Nobuhito Shibata, Kanji Takada, Y.V. Rama Prasad, Akihiro Matsuura
Publikováno v:
International Journal of Pharmaceutics. 271:225-232
Oral absorption of low molecular weight heparin (LMWH) is limited by its molecular size and negative charge. Development of its oral formulations would allow outpatient treatment with LMWH and decrease the hospital expenses. Studies were aimed at eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411378ce62a7bb11718b74f989d5a1f7
https://doi.org/10.1016/j.ijpharm.2003.11.013
https://doi.org/10.1016/j.ijpharm.2003.11.013
Autor:
Y.V. Rama Prasad, Yukako Yoshikawa, Sudarat Eaimtrakarn, Nobuhito Shibata, Kanji Takada, Shivanand P. Puthli
Publikováno v:
Drug Metabolism and Pharmacokinetics. 17:284-291
Salivary caffeine excretion rate test has been proposed for the evaluation of gastrointestinal transit characteristics of an oral patch preparation after administration to human volunteers instead of measuring the plasma or serum concentration in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2bc2d3969b014067590d88fbc7b438
https://doi.org/10.2133/dmpk.17.284
https://doi.org/10.2133/dmpk.17.284
Autor:
Kanji Takada, Takahiro Konishi, Nobuhito Shibata, Yukako Yoshikawa, Sudarat Eaimtrakarn, Y.V. Rama Prasad, Tomoya Ohno
Publikováno v:
Journal of Drug Targeting. 10:255-260
The oral absorption enhancing effect of Labrasol has been studied in rats using insulin as a model peptide/protein drug. Insulin solution was prepared by dissolving insulin in pH 7.4 buffer followed by the addition of Labrasol. The insulin concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d5b13d1cfbb6fdaf0d7d8270221a9e
https://doi.org/10.1080/10611860290022688
https://doi.org/10.1080/10611860290022688
Publikováno v:
Journal of Controlled Release. 55:245-252
A novel colon-specific drug delivery system based on a polysaccharide, guar gum, was evaluated by conducting gamma scintigraphic studies using technetium-99m-DTPA as tracer, in six healthy male human volunteers. Scintigraphs taken at regular interval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c7a3fba4697909fcdf50d340e1ef32
https://doi.org/10.1016/s0168-3659(98)00057-1
https://doi.org/10.1016/s0168-3659(98)00057-1
Publikováno v:
International Journal of Pharmaceutics. 171:137-146
Colon-specific drug delivery systems based on a polysaccharide, guar gum, were evaluated using in vitro and in vivo methods. In vitro drug release studies have shown that guar gum in the form of compression coat applied over indomethacin core tablets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90c1fe86a4e01df0a618435fb1b4e500
https://doi.org/10.1016/s0378-5173(98)00172-0
https://doi.org/10.1016/s0378-5173(98)00172-0
Publikováno v:
Journal of Controlled Release. 51:281-287
A novel tablet formulation for oral administration using guar gum as the carrier and indomethacin as a model drug has been investigated for colon-specific drug delivery using in vitro methods. Drug release studies under conditions mimicking mouth to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d025850160aa8ab8379f5a43fad868b4
https://doi.org/10.1016/s0168-3659(97)00181-8
https://doi.org/10.1016/s0168-3659(97)00181-8
Autor:
Kanji Takada, Y.V. Rama Prasad, Nobuyuki Sugioka, Nobuhito Shibata, Tomohiro Kusawake, Yukako Ito
Publikováno v:
International journal of pharmaceutics. 317(2)
Oral anticoagulant therapy with heparin has been challenged by formulating heparin in oral solid preparation. As heparin, low molecular weight heparin (LMWH) was used. LMWH was dispersed with a surfactant used for the self-microemulsifying drug deliv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3666165fb453a0c4d1c85fb34ae386a0
https://pubmed.ncbi.nlm.nih.gov/16631328
https://pubmed.ncbi.nlm.nih.gov/16631328
Autor:
Yukako Yoshikawa, Riichi Tawa, Makoto Ishida, Sudarat Eaimtrakarn, Yoichi Kusawake, Kanji Takada, Y.V. Rama Prasad, Nobuhito Shibata
Publikováno v:
International journal of pharmaceutics. 268(1-2)
Gentamicin (GM) is a polarized water-soluble compound having very poor intestinal membrane permeability resulting in low oral bioavailability. Labrasol was found to improve the intestinal absorption of GM in rats. In the present study, GM formulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52e483298aa25b2026245747bcbd4e6
https://pubmed.ncbi.nlm.nih.gov/14643972
https://pubmed.ncbi.nlm.nih.gov/14643972
Autor:
Sudarat Eaimtrakarn, Nobuhito Shibata, Kanji Takada, Yukako Yoshikawa, Shivanand P. Puthli, Y.V. Rama Prasad
Publikováno v:
International journal of pharmaceutics. 250(1)
A new oral patch system has been designed to increase the residence time of model drugs within the gastrointestinal tract. The system consisted of three layers (1) water-insoluble backing layer (2) drug-carrying adhesive layer composed of a model dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5e53fe89c7cbd4fa2aa580f134fd7f
https://pubmed.ncbi.nlm.nih.gov/12480277
https://pubmed.ncbi.nlm.nih.gov/12480277
Publikováno v:
Drug development and industrial pharmacy. 25(5)
The aim of this study was to develop colon-specific delivery systems for 5-aminosalicylic acid (5-ASA) using guar gum as a carrier. Core tablets containing 5-ASA were prepared by wet granulation with starch paste and were compression coated with coat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8fdb235e934a10a094c9f36b2a22a3
https://pubmed.ncbi.nlm.nih.gov/10219535
https://pubmed.ncbi.nlm.nih.gov/10219535