Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Y.S. Babu"'
Publikováno v:
Tetrahedron Letters. 114:154219
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61c01ac2aa3b246ab2b19a4c814e04f2
https://doi.org/10.1016/j.tetlet.2022.154219
https://doi.org/10.1016/j.tetlet.2022.154219
Autor:
Weihe Zhang, Satish Vadlakonda, Minwan Wu, Venkat Chintareddy, LN Vogeti, Luis Juarez, Saritha Muppa, Cynthia Parker, Debra Kellogg-Yelder, Jason Williams, Kevin Polach, Xilin Chen, Krishnan Raman, Y.S. Babu, Pravin Kotian
Publikováno v:
Bioorganic & Medicinal Chemistry. 73:117035
Hereditary angioedema (HAE) is a rare and potentially life-threatening disease that affects an estimated 1 in 50,000 individuals worldwide. Berotralstat (BCX7353) is the only small molecule approved by the US Food and Drug Administration (FDA) for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae50f54a4c811793fc4a36ecc56b659
https://doi.org/10.1016/j.bmc.2022.117035
https://doi.org/10.1016/j.bmc.2022.117035
Autor:
Y.S. Babu, Amanda Mathis, Justin G. Julander, Brian B. Gowen, Dennis M. Walling, Ray Taylor, James F. Demarest
Publikováno v:
Antiviral Research
Galidesivir (BCX4430) is an adenosine nucleoside analog that is broadly active in cell culture against several RNA viruses of various families. This activity has also been shown in animal models of viral disease associated with Ebola, Marburg, yellow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8044fd2740768fa2b3a0c64e5575495c
https://pubmed.ncbi.nlm.nih.gov/34551346
https://pubmed.ncbi.nlm.nih.gov/34551346
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Venkatraman Siddharthan, Justin G. Julander, Makda S. Gebre, Preston A. Collins, William P. Sheridan, Y.S. Babu, Young-Min Lee, Jason Stewart, Skot Neilson, Kelsey Tolbert, John D. Morrey, Ray Taylor, Chad Apuli, Joe Evans, Arnaud J. Van Wettere
Publikováno v:
Antiviral Research. 137:14-22
Zika virus (ZIKV) is currently undergoing pandemic emergence. While disease is typically subclinical, severe neurologic manifestations in fetuses and newborns after congenital infection underscore an urgent need for antiviral interventions. The adeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b0fe08af59e2b527ba2b7481911496
https://doi.org/10.1016/j.antiviral.2016.11.003
https://doi.org/10.1016/j.antiviral.2016.11.003
Autor:
J. Zhang, Jo Collier, J. Zong, Ramanda Wilson, L. Fang, Y.S. Babu, William P. Sheridan, Melanie Cornpropst, Phil Collis
Publikováno v:
Allergy. 71:1676-1683
Background Avoralstat is a potent small-molecule oral plasma kallikrein inhibitor under development for treatment of hereditary angioedema (HAE). This first-in-human study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa6f89a0524c1db416155a42f479e40
https://doi.org/10.1111/all.12930
https://doi.org/10.1111/all.12930
Autor:
Y.S. Babu, Jessica L. Kublin, Saverio Capuano, Dane Schalk, Gyeol Yoon, Alan S. Perelson, Christa E. Osuna, Ma Luo, Ray Taylor, Elsa Chen, David Safronetz, James B. Whitney, Amanda Mathis, Katharine Best, Nancy Schultz-Darken, Steve MacLennan, William P. Sheridan, So-Yon Lim
Publikováno v:
Sci Transl Med
Zika virus infection in humans has been associated with serious reproductive and neurological complications. At present, no protective antiviral drug treatment is available. Here, we describe the testing and evaluation of the antiviral drug, galidesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b205753f1a8d7c8496e3c183da319e68
https://pubmed.ncbi.nlm.nih.gov/32522808
https://pubmed.ncbi.nlm.nih.gov/32522808
Purine nucleoside phosphorylase (PNP) is part of the human purine salvage pathway. Its deficiency triggers apoptosis of activated T-cells, making it a target for T-cell proliferative disorders. Transition-state analogues of PNP bind with picomolar (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee42c0cedd3a6ddc8a3d5f95808f760e
https://europepmc.org/articles/PMC5612120/
https://europepmc.org/articles/PMC5612120/
