Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Y. Whitney Yin"'
Autor:
Rachel A. Caston, Paola Fortini, Kevin Chen, Jack Bauer, Eugenia Dogliotti, Y. Whitney Yin, Bruce Demple
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12715 (2023)
After cellular differentiation, nuclear DNA is no longer replicated, and many of the associated proteins are downregulated accordingly. These include the structure-specific endonucleases Fen1 and DNA2, which are implicated in repairing mitochondrial
Externí odkaz:
https://doaj.org/article/aabe021fbe59425c8c45609903af5d6d
Autor:
Geoffrey K. Herrmann, Y. Whitney Yin
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1195 (2023)
Poly(ADP-ribose) (PAR) Polymerase 1 (PARP-1), also known as ADP-ribosyl transferase with diphtheria toxin homology 1 (ARTD-1), is a critical player in DNA damage repair, during which it catalyzes the ADP ribosylation of self and target enzymes. While
Externí odkaz:
https://doaj.org/article/d4a638b49166464dba8887b9b0f1151a
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/43315b8ef4f4411b9626b15192b13698
Publikováno v:
Molecules, Vol 28, Iss 4, p 1796 (2023)
Human mitochondrial DNA (mtDNA) is a 16.9 kbp double-stranded, circular DNA, encoding subunits of the oxidative phosphorylation electron transfer chain and essential RNAs for mitochondrial protein translation. The minimal human mtDNA replisome is com
Externí odkaz:
https://doaj.org/article/8094e99a01ed46d5b0f93c3474e838e0
Autor:
Joon Park, Noe Baruch-Torres, Shigenori Iwai, Geoffrey K. Herrmann, Luis G. Brieba, Y. Whitney Yin
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Human mitochondrial DNA contains more UV-induced lesions than the nuclear DNA due to lack of mechanism to remove bulky photoproducts. Human DNA polymerase gamma (Pol γ) is the sole DNA replicase in mitochondria, which contains a polymerase (pol) and
Externí odkaz:
https://doaj.org/article/8fc7d8cbd6e9458ebace357e1e1126d5
Autor:
Yakun Liu, Tania M. Garron, Qing Chang, Zhengchen Su, Changcheng Zhou, Yuan Qiu, Eric C. Gong, Junying Zheng, Y. Whitney Yin, Thomas Ksiazek, Trevor Brasel, Yang Jin, Paul Boor, Jason E. Comer, Bin Gong
Publikováno v:
Pathogens, Vol 10, Iss 5, p 509 (2021)
The SARS-CoV-2 pandemic has inspired renewed interest in understanding the fundamental pathology of acute respiratory distress syndrome (ARDS) following infection. However, the pathogenesis of ARDS following SRAS-CoV-2 infection remains largely unkno
Externí odkaz:
https://doaj.org/article/3cd9e5867fb44056b7232fbd2bea5447
Autor:
Michal R. Szymanski, Wangsheng Yu, Aleksandra M. Gmyrek, Mark A. White, Ian J. Molineux, J. Ching Lee, Y. Whitney Yin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Human EXOG is crucial for mitochondrial DNA repair. Here the authors present the crystal structures of hEXOG in apo form and as DNA complex and suggest a `tape-measure' activity to generate optimal substrates for mitochondrial base excision repair.
Externí odkaz:
https://doaj.org/article/69b2fef277bd4fcea402f22d42c7215c
Publikováno v:
Nature Structural & Molecular Biology.
Publikováno v:
Journal of the American Chemical Society. 144(51)
Most oxidative damage on mitochondrial DNA is corrected by the base excision repair (BER) pathway. However, the enzyme that catalyzes the rate-limiting reaction─deoxyribose phosphate (dRP) removal─in the multienzymatic reaction pathway has not be
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