Výsledky vyhledávání

Synthesis and characterization of retro gramicidin A-dAla-gramicidin A, a 31-residue-long gramicidin analogue

Autor: Gérard Spach, Frédéric Heitz, Y. Trudelle, D. Lelievre

Publikováno v: International Journal of Peptide and Protein Research. 33:379-385

A 31-residue peptide, retro gramicidin A-dAla-gramicidin A, mimicking a gramicidin A dimer was prepared by solid phase method using a 4-(oxymethyl)-Pam resin and BOC as α amino protecting group. To avoid any possible formation of gramicidin A, coupl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63fedcee30c6bfebda333185ecc657cc
https://doi.org/10.1111/j.1399-3011.1989.tb00698.x

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High thermal stability and cold-denaturation of an artificial polypeptide

Autor: Agnès F. Delmas, C. Meunier, E. Lacassie, D. Sy, Y. Trudelle

Publikováno v: International Journal of Peptide and Protein Research
International Journal of Peptide and Protein Research, 1996, 48 (3), pp.249-58. ⟨10.1111/j.1399-3011.1996.tb00838.x⟩

International audience; An amphipathic polypeptide, Pn, with a tandemly repeated LKELPEKL sequence including a proline every eight residues, as well as a series of shorter peptides having the same sequence, P2, P3, P4, P5 and P6, were synthesized. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e4b3add090ccaf4fb5f5aa96138057
https://doi.org/10.1111/j.1399-3011.1996.tb00838.x

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Synthesis and characterization of Tyr(Bzl)9,11,13,15 and Tyr 9,11,13,15 gramicidin A

Autor: Y. Trudelle, F. Heitz

Publikováno v: International Journal of Peptide and Protein Research. 30:163-169

Tyr(Bzl) and Tyr gramicidin A were prepared by the solid phase method using a 4-(oxymethyl)-Pam resin and Bpoc as alpha-amino-protecting group. The benzylated analog [Gr.T(Bzl)] was purified by chromatography on silica gel and then on LH60 Sephadex.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c621d8607e6db50000a010f457e096
https://doi.org/10.1111/j.1399-3011.1987.tb03325.x

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Synthesis, conformation and reactivity towards p-nitrophenyl acetate of polypeptides incorporating aspartic acid, serine and histidine

Autor: Y. Trudelle

Publikováno v: International Journal of Peptide and Protein Research. 19:528-535

Examination of beta-carbons coordinates of seryl, aspartyl and histidyl residues in active sites of alpha-chymotrypsin and subtilisin BPN' shows that a close geometrical arrangement can be obtained in an antiparellel beta-structure. Therefore some po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412ef3ef663da8031d282cfacf5ef78c
https://doi.org/10.1111/j.1399-3011.1982.tb02638.x

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Interactions of basic amphiphilic peptides with dimyristoylphosphatidylcholine small unilamellar vesicles: Optical, NMR, and electron microscopy studies and conformational calculations

Autor: J. P. Grivet, D Sy, Y. Trudelle, J. A. Reynaud

Publikováno v: Biochemistry. 32:4997-5008

The interactions of DMPC small unilamellar vesicles with four amphiphilic polypeptides [(LKKL)n, (LRRL)n, (LKKL)4, and (YKKY)n] have been investigated by circular and infrared dichroism, turbidimetry, electron microscopy, and fluorescence, 1H, and 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d5c6aefecbd6ecbf42f855ca62830e
https://doi.org/10.1021/bi00070a005

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Gramicidin channels that have no tryptophan residues

Autor: V. Fonseca, L. Ranjalahy-Rasoloarijao, Y. Trudelle, Olaf S. Andersen, Frédéric Heitz, R. Lazaro, P. Daumas

Publikováno v: Biochemistry. 31:5340-5350

In order to understand how aromatic residues modulate the function of membrane-spanning proteins, we examined the role of the four tryptophans in gramicidin A (gA) in determining the average duration and permeability characteristics of membrane-spann

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7804ec2515116e09950b57974f7564
https://doi.org/10.1021/bi00138a014

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On the helix sense of gramicidin A single channels

Autor: Denise V. Greathouse, Y. Trudelle, Lyndon L. Providence, Roger E. Koeppe, Neil Purdie, Olaf S. Andersen, Frédéric Heitz

Publikováno v: Proteins: Structure, Function, and Genetics. 12:49-62

In order to resolve whether gramicidin A channels are formed by right- or left-handed beta-helices, we synthesized an optically reversed (or mirror image) analogue of gramicidin A, called gramicidin A-, to test whether it forms channels that have the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5a253b35c56b1d7c1f848264aef004
https://doi.org/10.1002/prot.340120107

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