Výsledky vyhledávání

Altered proliferation and differentiation of human epidermis in cases of skin fibrosis after radiotherapy

Autor: Virginie Sivan, Bernard Dubray, Michèle T. Martin, Jean-Marc Cosset, Marie-Catherine Vozenin-Brotons, Jean-Louis Lefaix, Y Tricaud

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 53:385-393

Purpose: To characterize, at the histopathologic and molecular levels, the irradiated epidermis in cases of human skin fibrosis induced by radiotherapy. Methods and Materials: Surgical samples were obtained from 6 patients who had developed cutaneous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9853ef326f672203133fccb3998f7eca
https://doi.org/10.1016/s0360-3016(01)02732-8

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Successful treatment of radiation-induced fibrosis using and Mn-SOD: An experimental study

Autor: Jean-Jacques Leplat, François Baillet, Abraham Nimrod, Y Tricaud, Michèle T. Martin, Sylvie Delanian, Jean-Louis Lefaix, François Daburon

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 35:305-312

Purpose: To establish how far liposomal copper/zinc superoxide dismutase (Cu/ZnSOD) and manganese superoxide dismutase (MnSOD), respectively, reduce radiation-induced fibrosis (RIF), using a well-characterized pig model of RIF permitting the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::331440d6ddc601375cd00189e331df88
https://doi.org/10.1016/0360-3016(96)00061-2

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Identification of five chromosomal regions involved in predisposition to melanoma by genome-wide scan in the MeLiM swine model

Autor: Francoise Créchet, Y Tricaud, Denis Milan, Michel Franck, Christine Renard, Vratislav Horak, Nathalie Iannuccelli, Gérard Frelat, Catherine Le Chalony, Silvia Vincent-Naulleau, Jean-Jacques Leplat, Stephan Bouet, J. Gruand, Claudine Geffrotin, Pascale Le Roy, Angela Silva Barbosa

Publikováno v: International Journal of Cancer
International Journal of Cancer, Wiley, 2004, 110, pp.39-50
HAL
International Journal of Cancer, 2004, 110, pp.39-50

In human familial melanoma, 3 risk susceptibility genes are already known, CDKN2A, CDK4 and MC1R. However, various observations suggest that other melanoma susceptibility genes have not yet been identified. To search for new susceptibility loci, we u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aab89ef9d1f1cb21fadae44ce6d1406
https://hal.inrae.fr/hal-02671158

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A new animal model for the imaging of melanoma: correlation of FDG PET with clinical outcome, macroscopic aspect and histological classification in Melanoblastoma-bearing Libechov Minipigs

Autor: Catherine Le Chalony, Raphaël Boisgard, Silvia Vincent-Naulleau, Jean-Jacques Leplat, Bertrand Tavitian, Claudine Geffrotin, Vratislav Horak, Gérard Frelat, Y Tricaud, Stephan Bouet

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging, 2003, 30, pp.826-834
Scopus-Elsevier
European Journal of Nuclear Medicine and Molecular Imaging, Springer Verlag (Germany), 2003, 30, pp.826-834

The aim of this study was to evaluate the Melanoblastoma-bearing Libechov Minipigs (MeLiM) as an animal model of melanoma for in vivo imaging. Serial whole-body 2-deoxy-2-[(18)F]fluoro- d-glucose positron emission tomography (FDG PET) scans were cond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4566b37ec4c9a2095a7870477256c63c
https://hal.inrae.fr/hal-02678138

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Opposite regulation of tenascin-C and tenascin-X in MeLiM swine heritable cutaneous malignant melanoma

Autor: Vratislav Horak, Philippe Vielh, Francoise Créchet, C Lethias, Claudine Geffrotin, Silvia Vincent-Naulleau, Y Tricaud

Interactions between tumour cells and surrounding extracellular matrix (ECM) influence the growth of tumour cells and their ability to metastasise. It is thus interesting to compare ECM composition in tumours and healthy tissues. Using the recently d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50560ef3eada358677a6460b3c550851
https://hal.archives-ouvertes.fr/hal-00314345

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Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: an experimental study

Autor: Jean-Jacques Leplat, Michèle T. Martin, Sylvie Delanian, Jean-Louis Lefaix, Y Tricaud, Marie-Catherine Vozenin

Publikováno v: International Journal of Radiation Oncology-Biology-Physics
International Journal of Radiation Oncology-Biology-Physics, Elsevier, 1999, 43 (4), pp.839-847. ⟨10.1016/S0360-3016(98)00419-2⟩
International Journal of Radiation Oncology, Biology, Physics
International Journal of Radiation Oncology, Biology, Physics, 1999, 43 (4), pp.839-847. ⟨10.1016/S0360-3016(98)00419-2⟩

International audience; Purpose: To establish a successful treatment of subcutaneous fibrosis developing after high doses of gamma rays, suitable for use in clinical practice. Methods and Materials: We used an animal model of acute localized gamma ir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93918727d6a62737e7a2539731ab8b3e
https://hal.inrae.fr/hal-02697701

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Unlike tenascin-X, tenascin-C is highly up-regulated in pig cutaneous and underlying muscle tissue developing fibrosis after necrosis induced by very high-dose gamma radiation

Autor: C, Geffrotin, Y, Tricaud, F, Crechet, M, Castelli, J L, Lefaix, M, Vaiman

Publikováno v: Radiation research. 149(5)

Fibrosis is characterized by proliferation of fibroblasts and deposition of extracellular matrix (ECM). As alterations in the composition of ECM may account for its chronic extension, we studied the expression of the tenascin-C (TN-C) and tenascin-X

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f1a7c0936dd2b7f316e666a7c7bf345
https://pubmed.ncbi.nlm.nih.gov/9588358

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Successful treatment of radiation-induced fibrosis using Cu/Zn-SOD and Mn-SOD: an experimental study

Autor: J L, Lefaix, S, Delanian, J J, Leplat, Y, Tricaud, M, Martin, A, Nimrod, F, Baillet, F, Daburon

Publikováno v: International journal of radiation oncology, biology, physics. 35(2)

To establish how far liposomal copper/zinc superoxide dismutase (Cu/Zn-SOD) and manganese superoxide dismutase (Mn-SOD), respectively, reduce radiation-induced fibrosis (RIF), using a well-characterized pig model of RIF permitting the design of a con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f80ddb8ea324ad0822aa7ee45bbc82d
https://pubmed.ncbi.nlm.nih.gov/8635938

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Muscular fibrosis induced after pig skin irradiation with single doses of 192Ir gamma-rays

Autor: M Martin, Y Tricaud, Jean-Louis Lefaix, F Daburon

Publikováno v: The British journal of radiology. 66(786)

Localized irradiation of the skin and subcutaneous tissues with large single doses of gamma-rays can induce delayed effects characterized by fibrosis which invades the irradiated tissues. In this study the depth of penetration of muscle fibrosis was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5876d77f5dc94a9a423e386e99d17de7
https://pubmed.ncbi.nlm.nih.gov/8330139

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