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Akademický článek

Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells

Autor: Yang Sun, Lu Hu, Zhipeng Tao, Gopala K. Jarugumilli, Hannah Erb, Alka Singh, Qi Li, Jennifer L. Cotton, Patricia Greninger, Regina K. Egan, Y. Tony Ip, Cyril H. Benes, Jianwei Che, Junhao Mao, Xu Wu

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Previously, the small molecule inhibitor of transcriptional enhanced associate domain (TEAD) MGH-CP1 has been described in stem cells. Here, the authors demonstrate the utility of MGH-CP1 in cancer therapy and find treatment to increase Akt pathway a

Externí odkaz: https://doaj.org/article/0a919bab3ce842f1938cd997f841b09b

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Akademický článek

Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila

Autor: Alicia Shields, Alla Amcheslavsky, Elizabeth Brown, Tom V. Lee, Yingchao Nie, Takahiro Tanji, Y. Tony Ip, Andreas Bergmann

Publikováno v: Cell Reports, Vol 39, Iss 7, Pp 110817- (2022)

Summary: Drosophila Toll-1 and all mammalian Toll-like receptors regulate innate immunity. However, the functions of the remaining eight Toll-related proteins in Drosophila are not fully understood. Here, we show that Drosophila Toll-9 is necessary a

Externí odkaz: https://doaj.org/article/6a1fc7ad54e6466c9b1985c50dc6f126

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Akademický článek

YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression

Autor: Huapeng Li, Qi Li, Kyvan Dang, Shan Ma, Jennifer L. Cotton, Sun Yang, Lihua J. Zhu, April C. Deng, Y. Tony Ip, Randy L. Johnson, Xu Wu, Claudio Punzo, Junhao Mao

Publikováno v: Cell Reports, Vol 29, Iss 10, Pp 3200-3211.e4 (2019)

Summary: Uveal melanoma (UM), the most common ocular malignancy, is characterized by GNAQ/11 mutations. Hippo/YAP and Ras/mitogen-activated protein kinase (MAPK) emerge as two important signaling pathways downstream of G protein alpha subunits of the

Externí odkaz: https://doaj.org/article/802444966e0647229f7493ecee80a44f

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Akademický článek

Enteroendocrine Cells Support Intestinal Stem-Cell-Mediated Homeostasis in Drosophila

Autor: Alla Amcheslavsky, Wei Song, Qi Li, Yingchao Nie, Ivan Bragatto, Dominique Ferrandon, Norbert Perrimon, Y. Tony Ip

Publikováno v: Cell Reports, Vol 9, Iss 1, Pp 32-39 (2014)

Summary: Intestinal stem cells in the adult Drosophila midgut are regulated by growth factors produced from the surrounding niche cells including enterocytes and visceral muscle. The role of the other major cell type, the secretory enteroendocrine ce

Externí odkaz: https://doaj.org/article/3c6317ccd6574b5dba070e3a1766982f

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TrpA1 is a shear stress mechanosensing channel regulating intestinal stem cell proliferation in Drosophila

Autor: Jiaxin Gong, Niraj K. Nirala, Jiazhang Chen, Fei Wang, Pengyu Gu, Qi Wen, Y. Tony Ip, Yang Xiang

Publikováno v: Science Advances. 9

Adult stem cells are essential for tissue maintenance and repair. Although genetic pathways for controlling adult stem cells are extensively investigated in various tissues, much less is known about how mechanosensing could regulate adult stem cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfe829ccae450ddbba6ac9cb0f663e99
https://doi.org/10.1126/sciadv.adc9660

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