Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Y. T. Candace Ho"'
Autor:
Y. T. Candace Ho, Thierry Izoré, Joe A. Kaczmarski, Edward Marschall, Minuri S. Ratnayake, Julien Tailhades, David L. Steer, Ralf B. Schittenhelm, Manuela Tosin, Colin J. Jackson, Max J. Cryle
Publikováno v:
Frontiers in Catalysis, Vol 3 (2023)
In nonribosomal peptide synthesis, condensation (C) domains are key catalytic domains that most commonly link carrier protein bound substrates to form peptides or depsipeptides. While adenylation domains have been well characterized due to their role
Externí odkaz:
https://doaj.org/article/024e1c8ed96e462289c72f4969cb2512
Autor:
Thierry Izoré, Y. T. Candace Ho, Joe A. Kaczmarski, Athina Gavriilidou, Ka Ho Chow, David L. Steer, Robert J. A. Goode, Ralf B. Schittenhelm, Julien Tailhades, Manuela Tosin, Gregory L. Challis, Elizabeth H. Krenske, Nadine Ziemert, Colin J. Jackson, Max J. Cryle
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes assembling complex natural products. Here, the structures of a Thermobifida fusca NRPS condensation domain bound to the substrate-bearing peptidyl carrier protein (PCP) domain provid
Externí odkaz:
https://doaj.org/article/fbb66a8fa3204b6a841066cc1c1e62db
Autor:
Y. T. Candace Ho, Ralf B. Schittenhelm, Dumitrita Iftime, Evi Stegmann, Julien Tailhades, Max J. Cryle
Publikováno v:
ChemBioChem. 24
Autor:
Rania A. Hashad, Edwina Jap, Joanne L. Casey, Y. T. Candace Ho, Alexander Wright, Claudia Thalmann, Mark Sleeman, David W. Lupton, Christoph E. Hagemeyer, Max J. Cryle, Remy Robert, Karen Alt
Publikováno v:
Chemistry – A European Journal. 29
A highly effective 2-step system for site-specific antibody modification and conjugation of the monoclonal antibody Herceptin (commercially available under Trastuzumab) in a cysteine-independent manner was used to generate labelled antibodies for in
Autor:
Y. T. Candace Ho, Ralf B. Schittenhelm, Dumitrita Iftime, Evi Stegmann, Julien Tailhades, Max J. Cryle
Publikováno v:
ChemBioChem. 24
The glycopeptide antibiotics (GPAs) are a clinically approved class of antimicrobial agents that classically function via inhibition of bacterial cell wall biosynthesis through sequestration of the precursor lipid II. The oxidative crosslinking of th
Publikováno v:
Methods in Molecular Biology ISBN: 9781071632130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eccc94fd3bb43ef76ef30998ef74c91a
https://doi.org/10.1007/978-1-0716-3214-7_9
https://doi.org/10.1007/978-1-0716-3214-7_9
Autor:
Max J. Cryle, Thierry Izoré, Julien Tailhades, Ka Ho Chow, Colin J. Jackson, Gregory L. Challis, David Steer, Elizabeth H. Krenske, Robert J. A. Goode, Nadine Ziemert, Manuela Tosin, Ralf B. Schittenhelm, Y. T. Candace Ho, Athina Gavriilidou, Joe A. Kaczmarski
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Non-ribosomal peptide synthetases are important enzymes for the assembly of complex peptide natural products. Within these multi-modular assembly lines, condensation domains perform the central function of chain assembly, typically by forming a pepti
Publikováno v:
ChemBioChem. 22:43-51
The glycopeptide antibiotics (GPAs) are a fascinating example of complex natural product biosynthesis, with the nonribosomal synthesis of the peptide core coupled to a cytochrome P450-mediated cyclisation cascade that crosslinks aromatic side chains
Autor:
Elena Riva, Otto Kostner, Dexter P. Bushell, Judith Havemann, Daniele Passarella, Y. T. Candace Ho, Daniel J. Leng, Francesca Ghiringhelli, Manuela Tosin, Ina Wilkening
Publikováno v:
Chemical Communications. 53:7088-7091
Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insi
Autor:
Daniele Passarella, Manuela Tosin, Daniel J. Leng, Judith Havemann, Ina Wilkening, Otto Kostner, Y. T. Candace Ho, Francesca Ghiringhelli, Elena Riva, Dexter P. Bushell
Publikováno v:
Chemical communications (Cambridge, England). 53(92)
Correction for ‘Novel chemical probes for the investigation of nonribosomal peptide assembly’ by Y. T. Candace Ho et al., Chem. Commun., 2017, 53, 7088–7091.