Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Y. Sudhakar Babu"'
Autor:
Raman Krishnan, Surendra K. Saini, Pooran Chand, Y. Sudhakar Babu, Scott R. Rowland, Shane Arnold, Yahya El-Kattan, Shanta Bantia, Pravin L. Kotian, Ramanda Upshaw
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:3934-3958
Factor VIIa (FVIIa), a serine protease enzyme, coupled with tissue factor (TF) plays an important role in a number of thrombosis-related disorders. Inhibition of TF x FVIIa occurs early in the coagulation cascade and might provide some safety advanta
Autor:
Hans Prydz, Pravin L. Kotian, C. Shane Arnold, Shanta Bantia, Cynthia Parker, Ramanda Upshaw, Pooran Chand, Y. Sudhakar Babu
Publikováno v:
Thrombosis Research. 117:343-349
Tissue factor (TF) is a transmembrane glycoprotein that binds its zymogen cofactor, Factor VIIa (FVIIa) on the cell surface. Together (TF/FVIIa) they activate Factor X (FX) and Factor IX (FIX) and start the extrinsic pathway of blood coagulation. As
Autor:
Tracy L. Hutchison, Yahya El-Kattan, Shanta Bantia, Pooran Chand, Y. Sudhakar Babu, A. Dehghani, Tsu-Hsing Lin, Shoukath M. Ali, Pravin L. Kotian, Wayne J. Brouillette, Scott R. Rowland
Publikováno v:
Journal of Medicinal Chemistry. 47:1919-1929
In further studies aimed toward identifying effective and safe inhibitors of influenza neuraminidases, we synthesized a series of multisubstituted cyclopentane amide derivatives. Amides prepared were 14 examples of N-substituted alkyl or aralkyl type
Autor:
Mark D. Erion, Charles E. Bugg, Y. Sudhakar Babu, Robert D. Elliott, Steven E. Ealick, Wayne C. Guida, John A. Montgomery, John A. Secrist, H. Jeanette Thomas
Publikováno v:
Journal of Medicinal Chemistry. 37:1109-1114
9-(3,3-Dimethyl-5-phosphonopentyl)guanine was synthesized and found to be a potent inhibitor of purine nucleoside phosphorylase (PNP) (IC 50 = 44 nM). A number of other functional end groups were investigated as phosphate mimics attached to the 9-pos
Autor:
Lawrence J. DeLucas, J.M. Petrash, Edwin M. Westbrook, Charles E. Bugg, Y. Sudhakar Babu, Karen M. Moore, Sthanam V.L. Narayana, T. G. Flynn, O. El-Kabbani
Publikováno v:
Journal of Molecular Biology. 218:695-698
Large crystals of porcine aldose reductase have been grown from polyethylene glycol solutions. The crystals are triclinic, space-group P 1, with a = 81.3 A , b = 85.9 A , c = 56.6 A , α = 102.3 °, β = 103.3 ° and ψ = 79.0 ° . The crystals grow
Publikováno v:
ChemInform. 37
Autor:
Y. Sudhakar Babu, et al. et al.
Publikováno v:
ChemInform. 32
Autor:
Y. Sudhakar Babu, Shanta Bantia, Gillian M. Air, Sandya L Ananth, Gerald M. Walsh, Anita A. Ghate
Publikováno v:
Antimicrobial agents and chemotherapy. 42(4)
Influenza neuraminidase (NA) plays an important role in viral replication, and characterization of viruses resistant to NA inhibitors will help elucidate the role of active-site residues. This information will assist in designing better inhibitors ta
Autor:
John A. Secrist, Steven E. Ealick, Jerry D. Rose, Mark D. Erion, Shri Niwas, John A. Montgomery, Charles E. Bugg, Y. Sudhakar Babu, Wayne C. Guida
Publikováno v:
Journal of medicinal chemistry. 36(13)
Alicyclic and heteroalicyclic derivatives of 9-deazaguanine (2-amino-1,5-dihydro-4H-pyrrolo[3,2-d] [pyrimidin-4-one) are, with one exception, potent inhibitors of purine nucleoside phosphorylase (PNP) equaling the corresponding 9-arylmethyl derivativ
Autor:
Scott R. Rowland, Raman Krishnan, Pooran Chand, Shanta Bantia, Yahya El-Kattan, Y. Sudhakar Babu, Surendra K. Saini, Ramanda Upshaw, Pravin L. Kotian, Shane Arnold
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:460
Corrigendum to ‘‘Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores” [Bioorg. Med. Chem. 17 (2009) 3934] Pravin