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Antibodies directed against the β1-integrin subunit and peptides containing the IKVAV sequence of laminin perturb neurite outgrowth of peripheral neurons on immature spinal cord substrata

Autor: Philippe Cochard, A.M. Duprat, E. Agius, Y. Sagot

Publikováno v: Neuroscience. 71:773-786

Neuron-substratum interactions regulating axon growth in the developing central nervous system of the rat have been studied by means of an in vitro bioassay: the tissue section culture. We have previously shown that purified chicken sensory or sympat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7839867c4372f0b5ceac354ecbf51fa
https://doi.org/10.1016/0306-4522(95)00447-5

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Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease

Autor: S. A. Tan, J.-C. Martinou, P. Aebischer, Y. Sagot, A. C. Kato, F. De Bilbao, Michel Dubois-Dauphin

Publikováno v: The Journal of Neuroscience. 15:7727-7733

Bcl-2 and its analogs protect different classes of neurons from apoptosis in several experimental situations. These proteins may therefore provide a means for treatment of neurodegenerative diseases. We examined the effects of Bcl-2 overexpression in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496b03c2bab08b6727ecc2d45056e772
https://doi.org/10.1523/jneurosci.15-11-07727.1995

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Hemopexin is synthesized in peripheral nerves but not in central nervous system and accumulates after axotomy

Autor: M.J. Guinaudy, Cathy Soula, Y Sagot, A.M. Duprat, P Ferrara, J.P. Swerts, Jean-Claude Guillemot, Philippe Cochard

Publikováno v: Journal of Biological Chemistry. 267:10596-10600

In adult mammals, injured axons regrow over long distances in peripheral nerves but fail to do so in the central nervous system. Analysis of molecular components of tissue environments that allow axonal regrowth revealed a dramatic increase in the le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68dd22baff19698ef833a7cccbce4cb9
https://doi.org/10.1016/s0021-9258(19)50058-8

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An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease

Autor: Y, Sagot, N, Toni, D, Perrelet, S, Lurot, B, King, H, Rixner, L, Mattenberger, P C, Waldmeier, A C, Kato

Publikováno v: British journal of pharmacology. 131(4)

Apoptosis and mitochondrial dysfunction are thought to be involved in the aetiology of neurodegenerative diseases. We have tested an orally active anti-apoptotic molecule (CGP 3466B) that binds to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a9e23f401b2cd42b7e659495fc8cf73
https://pubmed.ncbi.nlm.nih.gov/11030721

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IAP family proteins delay motoneuron cell death in vivo

Autor: D, Perrelet, A, Ferri, A E, MacKenzie, G M, Smith, R G, Korneluk, P, Liston, Y, Sagot, J, Terrado, D, Monnier, A C, Kato

Publikováno v: The European journal of neuroscience. 12(6)

Neuronal apoptosis inhibitory protein (NAIP), and human inhibitors of apoptosis 1 and 2 (HIAP1 and HIAP2) are three members of the mammalian family of antiapoptosis proteins called 'inhibitors of apoptosis' (IAP). These molecules can prevent apoptosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0bc14e523a4fea88f05bfc081722265f
https://pubmed.ncbi.nlm.nih.gov/10886345

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Injury-induced synthesis and release of apolipoprotein E and clusterin from rat neural cells

Autor: L. Mattenberger, Ann C. Kato, Y. Sagot, R. W. James, S. Messmer-Joudrier

Publikováno v: The European journal of neuroscience. 8(12)

Apolipoproteins in the brain have assumed major clinical importance since it was shown that one of the allelic forms of apolipoprotein E, apoE-4, is a risk factor for Alzheimer's disease. Using tissue culture of embryonic rat spinal cord, we examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b410596e294ae24d7a936682a4a20efa
https://pubmed.ncbi.nlm.nih.gov/8996815

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GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice

Autor: S. A. Tan, J P Hammang, A. C. Kato, Patrick Aebischer, Y Sagot

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 16(7)

Glial cell line-derived neurotrophic factor (GDNF), a member of the TG F-beta superfamily, has been shown to be a highly potent neurotrophic factor that enhances survival of various neuronal cell types including motoneurons. To assess its therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d106543ff1f85613704801096153bcc2
https://pubmed.ncbi.nlm.nih.gov/8601813

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Polymer encapsulated cell lines genetically engineered to release ciliary neurotrophic factor can slow down progressive motor neuronopathy in the mouse

Autor: E. Baetge, Patrick Aebischer, S. A. Tan, A. C. Kato, Y. Sagot, H. Schmalbruch

Publikováno v: The European journal of neuroscience. 7(6)

Ciliary neurotrophic factor (CNTF) has recently generated great interest due to its potential as a therapeutic agent for the treatment of human neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Because the systemic half-life of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf181041576c55849858f4d151590c22
https://pubmed.ncbi.nlm.nih.gov/7582105

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