Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Y. S. E. Cheng"'
Publikováno v:
Nature Structural Biology. 1:552-556
HIV-1 proteinase (HIV PR) is a dimeric enzyme composed of two identical polypeptide chains that associate with twofold symmetry. We have determined to 1.8 A the crystal structure of a covalently tethered dimer of HIV PR. The tethered dimer:inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c197d2620a71fafdd9343778939c6b12
https://doi.org/10.1038/nsb0894-552
https://doi.org/10.1038/nsb0894-552
Autor:
Dean L. Winslow, Sena Garber, Caroline Reid, Y. S. E. Cheng, Hodge Carl Nicholas, C. E. Patterson, P. E. Aldrich, Prabhakar K. Jadhav, M. J. Otto
Publikováno v:
Proceedings of the National Academy of Sciences. 90:7543-7547
Protease inhibitors are another class of compounds for treatment of human immunodeficiency virus (HIV)-caused disease. The emergence of resistance to the current anti-HIV drugs makes the determination of potential resistance to protease inhibitors im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398306193761e402dd34165e7106eb8c
https://doi.org/10.1073/pnas.90.16.7543
https://doi.org/10.1073/pnas.90.16.7543
Publikováno v:
Proteolytic Enzymes ISBN: 9783642478079
Many viruses code for specialized proteolytic enzymes which are essential for virus assembly (Korant, 1994). The viral enzymes appear to belong to one of the recognized protease classes, including serine, cysteine and aspartic active sites, but some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0513e2ef42ac04ea135f6f573c2a37ee
https://doi.org/10.1007/978-3-642-59816-6_6
https://doi.org/10.1007/978-3-642-59816-6_6
Publikováno v:
The Journal of biological chemistry. 271(1)
Several lines of transgenic mice were generated with either active or inactive forms of the human immunodeficiency virus type 1 (HIV-1) protease gene under the control of the mouse lens alpha A-crystallin promoter. Mice bearing the inactive protease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6002a8c406d9d008f29c813ee00f999e
https://pubmed.ncbi.nlm.nih.gov/8550598
https://pubmed.ncbi.nlm.nih.gov/8550598
Publikováno v:
Aspartic Proteinases ISBN: 9781461357612
HIV-1 protease (HIV PR) is essential for the replication of human immunodeficiency virus and is responsible for the processing of gag and gag-pol polyproteins. Thus, HIV PR has been the target of intensive efforts to design inhibitors [1–4]. The en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4acc1e52a503b0b03f5c674f04a759d
https://doi.org/10.1007/978-1-4615-1871-6_56
https://doi.org/10.1007/978-1-4615-1871-6_56
Human immunodeficiency virus type 1 (HIV-1) and HIV-2 proteases are dimers of identical subunits. We made a construct for the expression of recombinant one-chain HIV-2 protease dimer, which, like the previously described one-chain HIV-1 protease dime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e72bd10b4245080529cb3bb3516594
https://europepmc.org/articles/PMC240833/
https://europepmc.org/articles/PMC240833/
Autor:
Jim-Min Fang, Keng-Chang Tsai, A.-S. Yang, S.-C. Hsiao, Y.-S. E. Cheng, Jiun-Jie Shie, Chi-Huey Wong, S.-Y. Wang, C.-Y. Su
Publikováno v:
Synfacts. 2008:0119-0119
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::658334769d76468792a23c5c991b89b5
https://doi.org/10.1055/s-2007-992507
https://doi.org/10.1055/s-2007-992507
Publikováno v:
Journal of Biological Chemistry. 258:7746-7750
Treatment of human diploid fibroblastic cells with interferon induces the synthesis of two guanylate binding proteins (GBP) with molecular weights of 67,000 and 56,000. The Mr = 67,000 protein (67K GBP) is synthesized upon treatment with either alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5597215c1dd4cd8b6d4d32ace9c970bd
https://doi.org/10.1016/s0021-9258(18)32242-7
https://doi.org/10.1016/s0021-9258(18)32242-7
Publikováno v:
The EMBO Journal. 8:2009-2014
Transcriptional regulation of the gene encoding a guanylate-binding protein (GBP) by the two interferon (IFN) types was studied. GBP gene transcription was regulated by alpha IFN in a manner identical to that of previously described IFN-stimulated ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706a7b6f3efceef1f88c046df5930cde
https://doi.org/10.1002/j.1460-2075.1989.tb03608.x
https://doi.org/10.1002/j.1460-2075.1989.tb03608.x
Publikováno v:
Scopus-Elsevier
A cytosolic phosphoprotein phosphatase of Mr = 95,000 purified from bovine cardiac muscle, which contains a catalytic subunit of Mr = 35,000, is known to be associated with a Mg2+-activated p-nitrophenyl phosphatase activity. We have found that the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23457f21be4b08393541886bdc1afdd
https://doi.org/10.1016/s0021-9258(18)32257-9
https://doi.org/10.1016/s0021-9258(18)32257-9