Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Y. Rebecca Chin"'
Autor:
Qingling He, Jianyang Hu, Hao Huang, Tan Wu, Wenxiu Li, Saravanan Ramakrishnan, Yilin Pan, Kui Ming Chan, Liang Zhang, Mengsu Yang, Xin Wang, Y. Rebecca Chin
Publikováno v:
Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with an unmet clinical need, but its epigenetic regulation remains largely undefined. By performing multiomic profiling, we recently revealed distinct super-enhan
Externí odkaz:
https://doaj.org/article/3bdf41726eb64b13ab397d8213e002d9
Akt3 promotes cancer stemness in triple-negative breast cancer through YB1-Snail/Slug signaling axis
Publikováno v:
Genes and Diseases, Vol 10, Iss 2, Pp 301-306 (2023)
Externí odkaz:
https://doaj.org/article/d80094c6baec4dc2a205f09b8f92c404
Autor:
Hao Huang, Jianyang Hu, Alishba Maryam, Qinghua Huang, Yuchen Zhang, Saravanan Ramakrishnan, Jingyu Li, Haiying Ma, Victor W. S. Ma, Wah Cheuk, Grace Y. K. So, Wei Wang, William C. S. Cho, Liang Zhang, Kui Ming Chan, Xin Wang, Y. Rebecca Chin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognostic outcomes. Here the authors characterize super-enhancer heterogeneity and they identify genes that are specifically regulated by TNBC-specific super-enhan
Externí odkaz:
https://doaj.org/article/abbe2a31ae264afda36fe681ddcc9d63
Autor:
Alishba Maryam, Y. Rebecca Chin
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
ANLN is frequently upregulated in triple-negative breast cancer (TNBC) and its high expression in tumors are significantly associated with poor survival and recurrence, thereby it has been proposed to function as a prognostic marker for breast cancer
Externí odkaz:
https://doaj.org/article/12d89deadcd1400696eb8691e7c954ae
Autor:
Fei Wang, Ling Sum Liu, Pan Li, Cia Hin Lau, Hoi Man Leung, Y Rebecca Chin, Chung Tin, Pik Kwan Lo
Publikováno v:
Materials Today Bio, Vol 15, Iss , Pp 100299- (2022)
Compared with siRNAs or other antisense oligonucleotides (ASOs), the chemical simplicity, DNA/RNA binding capability, folding ability of tertiary structure, and excellent physiological stability of threose nucleic acid (TNA) motivate scientists to ex
Externí odkaz:
https://doaj.org/article/9bf1498ca33a40259d59fc8e02323968
Upregulation of AKT3, but not AKT1 or AKT2, in AKT inhibitor-resistant MDA-MB-468 breast tumor cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01af48831c06764327672b8dbbd0402e
https://doi.org/10.1158/1535-7163.22507515
https://doi.org/10.1158/1535-7163.22507515
PDF file 1017K, Figure S1 shows the functions of Akt1 and Akt2 in the proliferation and migration of prostate tumor cells. Figure S2 demonstrates that all three Akt isoforms play a critical role in MDA-MB-468 breast cancer cell proliferation and form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6677b37519fcbbbce87255e8010bafa6
https://doi.org/10.1158/2159-8290.22530027.v1
https://doi.org/10.1158/2159-8290.22530027.v1
Knockdown of AKT1 or AKT2 does not sensitizes AKTi-resistant breast tumor cells to MK2206.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e86207f3d0dac853450b56a68b5e8a
https://doi.org/10.1158/1535-7163.22507512
https://doi.org/10.1158/1535-7163.22507512
Acquired resistance to molecular targeted therapy represents a major challenge for the effective treatment of cancer. Hyperactivation of the PI3K/AKT pathway is frequently observed in virtually all human malignancies, and numerous PI3K and AKT inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dce5c8ef5133a038ef5445df17b44626
https://doi.org/10.1158/1535-7163.c.6538713.v1
https://doi.org/10.1158/1535-7163.c.6538713.v1
Knockdown of AKT3 sensitizes AKTi-resistant breast tumor cells to MK2206.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162ec764ae2cafe63b133d1dc2ccefb8
https://doi.org/10.1158/1535-7163.22507509
https://doi.org/10.1158/1535-7163.22507509