Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Y. P. Dragan"'
Autor:
R M, O'Regan, A, Cisneros, G M, England, J I, MacGregor, H D, Muenzner, V J, Assikis, M M, Bilimoria, M, Piette, Y P, Dragan, H C, Pitot, R, Chatterton, V C, Jordan
Publikováno v:
JNCI Journal of the National Cancer Institute. 90:1552-1558
Background Tamoxifen has been shown to promote the growth of human endometrial tumors implanted in athymic mice, and it has been associated with a twofold to threefold increase in endometrial cancer. Toremifene, a chlorinated derivative of tamoxifen,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5113053f0e2b383e004dfd92452299a3
https://doi.org/10.1093/jnci/90.20.1552
https://doi.org/10.1093/jnci/90.20.1552
Publikováno v:
Toxicological Sciences. 43:129-138
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::559b867c4134dc021e7ce78a6eb7b020
https://doi.org/10.1093/toxsci/43.2.129
https://doi.org/10.1093/toxsci/43.2.129
Autor:
Y. P. DRAGAN, T. RIZVI, Y-H. XU, J. R. HULLY, N. BAWA, H. A. CAMPBELL, R. R. MARONPOT, H. C. PITOT
Publikováno v:
Toxicological Sciences. 16:525-547
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375e53c1d6b3b645527ed472cfdefff3
https://doi.org/10.1093/toxsci/16.3.525
https://doi.org/10.1093/toxsci/16.3.525
Autor:
Y P Dragan, F S Wolenski
Publikováno v:
Cell Death & Disease
The ability to detect and monitor potential toxicities of new clinical candidates is an absolute necessity for any pharmaceutical agent before the clinic. This safety profile is established during pre-clinical development through in vitro assays and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20528a39e5a965074774d6c36547a94a
https://doi.org/10.1038/cddis.2015.321
https://doi.org/10.1038/cddis.2015.321
Publikováno v:
Molecular carcinogenesis. 28(1)
Neoplastic development is a multistep process that involves the stochastic accumulation of heritable genetic alterations in proto-oncogenes, DNA repair genes, and tumor suppressor genes. Loss of heterozygosity (LOH) analysis has been used successfull
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d0758d13fde395bbd21d483af97184d
https://pubmed.ncbi.nlm.nih.gov/10820488
https://pubmed.ncbi.nlm.nih.gov/10820488
Publikováno v:
Molecular carcinogenesis. 25(3)
An albumin-simian virus 40 (SV40) large T-antigen (T-Ag) transgenic model and a chemically induced model of multistage hepatocarcinogenesis were created in our laboratory to study the molecular mechanisms involved in the genesis and progression of ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26fe5c3e211358d351684b51ac8cd266
https://pubmed.ncbi.nlm.nih.gov/10411141
https://pubmed.ncbi.nlm.nih.gov/10411141
Publikováno v:
Cancer research. 57(16)
Hepatocytes isolated from 3-month-old female rats bearing the albumin promoter/enhancer SV40 T antigen construct as a transgene demonstrated a 20% aneuploidy rate and a significant duplication of chromosome 1. Other chromosome changes were observed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::420baf9c415adbdf5540a64eda836a1a
https://pubmed.ncbi.nlm.nih.gov/9270012
https://pubmed.ncbi.nlm.nih.gov/9270012
Publikováno v:
Cancer research. 55(8)
The nonsteroidal antiestrogen tamoxifen is widely used in breast cancer treatment and is currently under evaluation as a chemopreventive agent for individuals at high risk of contracting the disease. The effects of tamoxifen administration on the exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9cc7a5a77bce96bbf2780e2e4983aa52
https://pubmed.ncbi.nlm.nih.gov/7712488
https://pubmed.ncbi.nlm.nih.gov/7712488
Autor:
H C, Pitot, Y P, Dragan
Publikováno v:
Progress in clinical and biological research. 391
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::40eb0d1b6e352cf0fb8e6be81867c65c
https://pubmed.ncbi.nlm.nih.gov/8532718
https://pubmed.ncbi.nlm.nih.gov/8532718
Autor:
L M, Sargent, Y P, Dragan, N, Bahnub, J E, Wiley, C A, Sattler, P, Schroeder, G L, Sattler, V C, Jordan, H C, Pitot
Publikováno v:
Cancer research. 54(13)
Tamoxifen has found extensive use in the treatment of all stages of human breast cancer. The efficacy of tamoxifen treatment for the prevention of second primary tumors and its chemosuppressive action in animal models have led to initiation of clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e00e630c30766a7921a401128f77f24
https://pubmed.ncbi.nlm.nih.gov/8012949
https://pubmed.ncbi.nlm.nih.gov/8012949