Zobrazeno 1 - 10
of 409
pro vyhledávání: '"Y. LEBLANC"'
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Therapeutic monoclonal antibodies (mAbs) are highly complex proteins that must be exhaustively characterized according to the regulatory authorities' recommendations. MAbs display micro-heterogeneity mainly due to their post-translational modificatio
Externí odkaz:
https://doaj.org/article/dbd6707f7d604439a51f703590da1b35
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Therapeutic monoclonal antibodies (mAbs) are highly complex proteins that must be exhaustively characterized according to the regulatory authorities' recommendations. MAbs display micro-heterogeneity mainly due to their post-translational modificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cee90acde2c464a8c4d4707b22ee10f
https://doi.org/10.1080/19420862.2020.1781743
https://doi.org/10.1080/19420862.2020.1781743
Publikováno v:
Journal of Chromatography B. 1095:87-93
Human Serum Albumin is the most abundant protein of the plasma and displays a wide range of non-oncotic properties such as antioxidant activity, distribution in tissues and organs of binding molecules and clearance of toxic compounds. Albumin is susc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd577fe04892ffa0d0c2cd714f66c28f
https://doi.org/10.1016/j.jchromb.2018.07.014
https://doi.org/10.1016/j.jchromb.2018.07.014
Autor:
Marc Corbière, Y Leblanc, Martine Vallarino, L De Benedictis, Alain Lesage, Amélie Felx, Massimo Miglioretti, Jean-François Pelletier, Filippo Rapisarda
Publikováno v:
Epidemiology and Psychiatric Sciences
Aims No instrument has been developed to explicitly assess the professional culture of mental health workers interacting with severely mentally ill people in publicly or privately run mental health care services. Because of theoretical and methodolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2527974005a745aac179865b4d1b279
https://doi.org/10.1017/s2045796019000787
https://doi.org/10.1017/s2045796019000787
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 149:541-546
Despite significant analytical improvements during this last decade, characterizing the whole integrity of monoclonal antibodies during their bioproduction remains a challenge. In this study, we report a new analytical approach to evaluate the overal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cf159c063d3068610f82db230a114a
https://doi.org/10.1016/j.jpba.2017.11.046
https://doi.org/10.1016/j.jpba.2017.11.046
Autor:
Valegh Faid, Nicolas Bihoreau, C. Ramon, M. Martin, Nolwenn Tilly, Y. Leblanc, Guillaume Chevreux, F. Dhainaut
Publikováno v:
Haemophilia. 23:e324-e334
Background The bypassing agent factor VII (FVIIa) is a first-line therapy for the treatment of acute bleeding episodes in patients with haemophilia and high-titre inhibitors. FVIIa is a highly post-translationally modified protein that requires eukar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685e09b3092ac43165401daf8f447100
https://doi.org/10.1111/hae.13253
https://doi.org/10.1111/hae.13253
Publikováno v:
Protein Sci
Human serum albumin (HSA) is the most abundant protein in plasma and presents the particularity, with IgG, to have an extraordinary long serum half‐life conferred by its interaction with the neonatal Fc receptor (FcRn). If the impact of IgG post‐
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8eae3b806510b356c36f9c322556d96
https://pubmed.ncbi.nlm.nih.gov/31583777
https://pubmed.ncbi.nlm.nih.gov/31583777
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 102:185-190
A number of intravenous immunoglobulin preparations are stabilized with sugar additives that may lead over time to undesirable glycation reactions especially in liquid formulation. This study aimed to evaluate the reactivity of sugar excipients on su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec6f7d47a4a325f5692e0385406ce11
Publikováno v:
Journal of Chromatography B. 1133:121814
Monoclonal antibodies (mAbs) are heterogeneous macromolecules that display a complex isoform profile as a result of the large series of modifications they can undergo. Product-related charge variants that are associated with a loss of biological acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cffda5f2fc6025c8c78a90afb9f0f50
https://doi.org/10.1016/j.jchromb.2019.121814
https://doi.org/10.1016/j.jchromb.2019.121814
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