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Elektronická kniha

Pharmacology of Ionic Channel Function: Activators and Inhibitors

Cells maintain uneven distribution of Na, K and Ca ions across the cell membrane and membranes of intracellular organellae. Cells exert their functions by allowing for some ion to cross the membrane through ion channels which either produces an elect

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Muscarinic K+ Channels Are Activated by βγ Subunits and Inhibited by the GDP-Bound Form of α Subunit of Transducin

Autor: Kiwamu Takahashi, Y. Kurachi, R.H. Lee, K. Kontani, Toshiaki Katada, Y.K. Ho, Misa Yamada

Publikováno v: Biochemical and Biophysical Research Communications. 200:1484-1490

It was reported that transducin beta gamma subunits (T beta gamma) inhibited cardiac muscarinic K+ (KACh) channels activated through GK. This result has been used to support the proposal that GK activates this channel through its alpha subunits. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd0682af376def2cd874cb2f82a1100
https://doi.org/10.1006/bbrc.1994.1618

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A platform for in silico modeling of physiological systems III

Autor: Y. Suzuki, Y. Asai, H. Oka, E. Heien, T. Urai, T. Okamoto, Y. Yumikura, K. Tominaga, Y. Kido, M. Nakanishi, K. Hagihara, Y. Kurachi, T. Nomura

Publikováno v: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2009

Physiome and systems biology have been recognized as emerging and important research areas that can integrate quantitatively growing knowledge about biological structure and physiological functions at multiple scales of time and space. For the integr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ac5f3f71ab515abf3f16a3ed7ec2ea
https://pubmed.ncbi.nlm.nih.gov/19964264

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Synthesis and properties of poly (organophosphazenes) ionomers [NP(HNC6H5)2−(x+y)(HNC6H4SO3H)x (HNC6H4SO3Li)y]n

Autor: Meisetsu Kajiwara, Y. Kurachi

Publikováno v: Journal of Materials Science. 26:1799-1802

Poly(anilino sulphamicphosphazenes) such as [NP(HNC6H5)2−x(HNC6H4SO3H)x]n for polymer (I) x=0.3 and for polymer (II) x=0.8 were prepared by the reaction of poly(anilinophosphazene) [NP(HNC6H5)2]n and sulphonic chloride HSO3Cl in tetrachloroethane s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61bc5335128c11601e90c2921177db73
https://doi.org/10.1007/bf00543605

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Characterization of a novel ATP-sensitive K+ channel opener, A-251179, on urinary bladder relaxation and cystometric parameters

Autor: C-C, Shieh, M E, Brune, S A, Buckner, K L, Whiteaker, E J, Molinari, I A, Milicic, A C, Fabiyi, A, Daza, J D, Brioni, W A, Carroll, K, Matsushita, M, Yamada, Y, Kurachi, M, Gopalakrishnan

Publikováno v: British journal of pharmacology. 151(4)

ATP-sensitive K(+) channels (K(ATP)) play a pivotal role in contractility of urinary bladder smooth muscle. This study reports the characterization of 4-methyl-N-(2,2,2-trichloro-1-(3-pyridin-3-ylthioureido)ethyl)benzamide (A-251179) as a K(ATP) chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::73be7c4195b647f57080b32d5bd1ed2c
https://pubmed.ncbi.nlm.nih.gov/17435796

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Overexpression of monomeric and multimeric GIRK4 subunits in rat atrial myocytes removes fast desensitization and reduces inward rectification of muscarinic K(+) current (I(K(ACh))). Evidence for functional homomeric GIRK4 channels

Autor: K, Bender, M C, Wellner-Kienitz, A, Inanobe, T, Meyer, Y, Kurachi, L, Pott

Publikováno v: The Journal of biological chemistry. 276(31)

K(+) channels composed of G-protein-coupled inwardly rectifying K(+) channel (GIRK) (Kir3.0) subunits are expressed in cardiac, neuronal, and various endocrine tissues. They are involved in inhibiting excitability and contribute to regulating importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe52d473eca84d7dae59fb3e329add4b
https://pubmed.ncbi.nlm.nih.gov/11384974

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