Zobrazeno 1 - 10
of 251
pro vyhledávání: '"Y. Hsiou"'
Autor:
Edward Arnold, Gunther Riess, Stephen H. Hughes, Irvin Winkler, Y. Hsiou, Arthur D. Clark, Manfred Rösner, Jianping Ding, Kalyan Das, Jörg Peter Kleim
Publikováno v:
Journal of Molecular Biology. 284:313-323
The second generation Hoechst-Bayer non-nucleoside inhibitor, HBY 097 ( S -4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-dihydroqui noxalin-2(1 H )-thione), is an extremely potent inhibitor of HIV-1 reverse transcriptase (RT) and of HIV-1 i
Publikováno v:
Structure. 4(7):853-860
Background: HIV-1 reverse transcriptase (RT) is a major target for anti-HIV drugs. A considerable amount of information about the structure of RT is available, both unliganded and in complex with template-primer or non-nucleoside RT inhibitors (NNRTI
Autor:
Y. Hsiou, Reinhard Kirsch, Irvin Winkler, Gunther Riess, Manfred Rösner, Edward Arnold, Arno Paessens, Jorg-Peter Kleim
Publikováno v:
Proceedings of the National Academy of Sciences. 93:34-38
The quinoxaline nonnucleoside RT inhibitor (NNRTI) (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4- dihydroquinoxaline-2(1H)-thione (HBY 097) was used to select for drug-resistant HIV-1 variants in vitro. The viruses first developed mutat
Autor:
Edward Arnold, Holly Bazmi, R. F. Schinazi, J. Weir, D. L. Mayers, John W. Mellors, Y. Hsiou, B. M. Roy
Publikováno v:
Antimicrobial Agents and Chemotherapy. 39:1087-1092
Foscarnet (phosphonoformic acid) is a pyrophosphate analog that inhibits the replication of human immunodeficiency virus type 1 (HIV-1) in vitro and in patients with AIDS. HIV-1 resistance to foscarnet has not been reported despite long-term foscarne
Autor:
P. A. J. Janssen, Christopher J. Michejda, S.H. Hughes, Y. Hsiou, Eddy Arnold, Arthur D. Clark, S Jessen, Jianping Ding, Kalyan Das, Rudi Pauwels, Xiaode Lu, Wanyi Zhang, Richard H. Smith, Chris Tantillo, Luc Koymans, Henri Moereels, Koenraad Jozef Lodewijk Marcel Andries, Alfredo Jacobo-Molina, M.Kroeger Koepke
Publikováno v:
Structure. 3:365-379
Background: HIV-1 reverse transcriptase (RT) is a multifunctional enzyme that copies the RNA genome of HIV-1 into DNA. It is a heterodimer composed of a 66 kDa (p66) and a 51 kDa (p51) subunit. HIV-1 RT is a crucial target for structure-based drug de
Autor:
Marianne P. Byrn, Philip Andrew Sawin, A. Terzis, Charles E. Strouse, T. Huang, S. K. Tendick, C. J. Curtis, Y. Hsiou, I. Goldberg, Saeed I. Khan
Publikováno v:
Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals. 211:135-140
Structural systematics, programmability, and guest transport are discussed for a large class of lattice clathrates based on tetraarylporphyrins.
Publikováno v:
AIHce 2005.
Autor:
Stephen H. Hughes, Paul L. Boyer, Arthur D. Clark, Jianping Ding, Manfred Rösner, Paul J. Lewi, Kalyan Das, Paul A. J. Janssen, Jorg-Peter Kleim, Y. Hsiou, Edward Arnold
Publikováno v:
Journal of molecular biology. 309(2)
Inhibitors of human immunodeficiency virus (HIV) reverse transcriptase (RT) are widely used in the treatment of HIV infection. Loviride (an alpha-APA derivative) and HBY 097 (a quinoxaline derivative) are two potent non-nucleoside RT inhibitors (NNRT
Autor:
Chris Tantillo, Kalyan Das, Y. Hsiou, Stefan G. Sarafianos, Alfredo Jacobo-Molina, Stephen H. Hughes, Edward Arnold, Jianping Ding, Arthur D. Clark
Publikováno v:
Journal of molecular biology. 284(4)
The structure of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) complexed with a 19-mer/18-mer double-stranded DNA template-primer (dsDNA) and the Fab fragment of monoclonal antibody 28 (Fab28) has been refined at 2.8 A resolu