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Akademický článek

Seasonal variations in the production of singlet oxygen and organic triplet excited states in aqueous PM2.5 in Hong Kong SAR, South China

Autor: Y. Lyu, Y. H. Lam, Y. Li, N. Borduas-Dedekind, T. Nah

Publikováno v: Atmospheric Chemistry and Physics, Vol 23, Pp 9245-9263 (2023)

Photooxidants drive many atmospheric chemical processes. The photoexcitation of light-absorbing organic compounds (i.e., brown carbon, BrC) in atmospheric waters can lead to the generation of reactive organic triplet excited states (3C∗), which can

Externí odkaz: https://doaj.org/article/87ba2ffc27104798b55db9d07fd79360

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Akademický článek

Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype

Externí odkaz: https://doaj.org/article/e7d5a888c2a540aeac4077803967b5d5

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Akademický článek

Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells

Autor: Ming Yang, Tamana Darwish, Pierre Larraufie, Debra Rimmington, Irene Cimino, Deborah A. Goldspink, Benjamin Jenkins, Albert Koulman, Cheryl A. Brighton, Marcella Ma, Brian Y. H. Lam, Anthony P. Coll, Stephen O’Rahilly, Frank Reimann, Fiona M. Gribble

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)

Abstract Even though metformin is widely used to treat type2 diabetes, reducing glycaemia and body weight, the mechanisms of action are still elusive. Recent studies have identified the gastrointestinal tract as an important site of action. Here we u

Externí odkaz: https://doaj.org/article/3277fbedd1ef4a0488a75dc21d27c7a7

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Akademický článek

Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function.

Autor: Constanze M Hammerle, Ionel Sandovici, Gemma V Brierley, Nicola M Smith, Warren E Zimmer, Ilona Zvetkova, Haydn M Prosser, Yoichi Sekita, Brian Y H Lam, Marcella Ma, Wendy N Cooper, Antonio Vidal-Puig, Susan E Ozanne, Gema Medina-Gómez, Miguel Constância

Publikováno v: PLoS Genetics, Vol 16, Iss 10, p e1009069 (2020)

The genetic mechanisms that determine the size of the adult pancreas are poorly understood. Imprinted genes, which are expressed in a parent-of-origin-specific manner, are known to have important roles in development, growth and metabolism. However,

Externí odkaz: https://doaj.org/article/dd9ff8b3a079402997344c273ba5478c

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Akademický článek

Caregivers’ Grit Moderates the Relationship Between Children’s Executive Function and Aggression

Autor: Bess Y. H. Lam, Adrian Raine, Annis L. C. Fung, Yu Gao, Tatia M. C. Lee

Publikováno v: Frontiers in Psychology, Vol 11 (2020)

ObjectivePrevious studies have shown that the impairment of executive function is positively related to aggression in children and adolescents. What is worth investigating is the moderator of such a relationship so that aggressive behavior can be red

Externí odkaz: https://doaj.org/article/d0dc6e268e094890a2d0a9037cb34213

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Akademický článek

p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Emerging studies suggest that p53 is an important regulator of energy metabolism, yet there is little known about the metabolic function of this tumor suppressor in the hypothalamus. Here, authors illustrate that p53, specifically in AgRP neurons, is

Externí odkaz: https://doaj.org/article/e3abcb467c8540338b4c0581b476791c

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Akademický článek

Neural Processes of Proactive and Reactive Controls Modulated by Motor-Skill Experiences

Autor: Qiuhua Yu, Bolton K. H. Chau, Bess Y. H. Lam, Alex W. K. Wong, Jiaxin Peng, Chetwyn C. H. Chan

Publikováno v: Frontiers in Human Neuroscience, Vol 13 (2019)

This study investigated the experience of open and closed motor skills on modulating proactive and reactive control processes in task switching. Fifty-four participants who were open-skilled (n = 18) or closed-skilled athletes (n = 18) or non-athleti

Externí odkaz: https://doaj.org/article/5c5bbaf18d9f48faaa24848d4149f807

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