Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Y. Fulmer Shealy"'
Publikováno v:
Journal of Cancer Therapy. :1008-1033
Several natural and synthetic retinoids (vitamin-A derived analogies) were examined for their potential anti-cancer activity in both in vivo animal models and a novel in vitro human keratinocyte clonal growth bioassay system. The natural retinoids in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::323a0c7b9a5c20fc97480dc06ec5756b
https://doi.org/10.4236/jct.2016.713098
https://doi.org/10.4236/jct.2016.713098
Autor:
Y. Fulmer Shealy, Paula W. Allan, L. Lee Bennett, William B. Parker, Isabelle Fourel, Donna S. Shewach, G. Arnett, William S. Mason
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:1045-1051
The carbocyclic analog of 2′-deoxyguanosine (CdG) has broad-spectrum antiviral activity. Because of recent observations with other nucleoside analogs that biological activity may be associated the l enantiomer rather than, as expected, with the d e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a87975a2755525f6e615d3317ddff031
https://doi.org/10.1128/aac.42.5.1045
https://doi.org/10.1128/aac.42.5.1045
Publikováno v:
Biochemical and Biophysical Research Communications. 223:293-298
Retinyl methyl ether (RME) which prevents cancers of the rat mammary gland, binds to cellular retinol-binding protein and serum retinol-binding protein but not to cellular retinoic acid-binding protein or to the nuclear retinoid receptors, RARs/RXRs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6429f0080e685c0b676e8f70313ec5
https://doi.org/10.1006/bbrc.1996.0887
https://doi.org/10.1006/bbrc.1996.0887
Publikováno v:
Tetrahedron. 52:405-424
Retinyl propynyl ether (RPE) undergoes an intramolecular Diels-Alder reaction to form a tetrahydroisobenzofuran derivative by addition of the alkyne group at positions 11 and 14 of the retinoid side chain. The Diels-Alder product can be isolated afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9153b76c74edb5c5512a94bd73e4ba44
https://doi.org/10.1016/0040-4020(95)00898-5
https://doi.org/10.1016/0040-4020(95)00898-5
Publikováno v:
Carcinogenesis. 16:2531-2534
The cellular transport, metabolism and biological activity of retinoids are mediated by their specific binding proteins and nuclear receptors. For an understanding of the mode of action of retinoids with potential cancer chemopreventive or other biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16dc45588fb9cf526a32526b498978f2
https://doi.org/10.1093/carcin/16.10.2531
https://doi.org/10.1093/carcin/16.10.2531
Autor:
C. Allen O'Dell, Y. Fulmer Shealy
Publikováno v:
Nucleosides and Nucleotides. 13:1929-1937
A new method for obtaining carbocyclic analogues of 3′,4′-didehydro-2,4(1H,3H)-pyrimidinedione nucleosides in good yields consists of the reaction of the carbocyclic 2,3′-anhydronucleosides with lithium chloride in dimethylformamide. Small amou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ba20e4e3946c37784871c1fa177e489
https://doi.org/10.1080/15257779408010673
https://doi.org/10.1080/15257779408010673
Publikováno v:
Synthesis. 1993:1095-1098
Alkylation of methyl 4-oxoretinoate under kinetic-control conditions gives predominantly 3-alkyl-4-oxoretinoates. 3,3-Disubstituted 4-oxoretinoates are obtained similarly from the 3-monosubstituted derivatives, although introduction of the second sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a58c1ff4ace31d2895e119235e5d942
https://doi.org/10.1055/s-1993-26008
https://doi.org/10.1055/s-1993-26008
Phosphorylation of the carbocyclic analog of 2′-deoxyguanosine in cells infected with herpes viruses
Autor:
L. Lee Bennett, Paula W. Allan, Y. Fulmer Shealy, William M. Shannon, G. Arnett, Lucy M. Rose
Publikováno v:
Biochemical Pharmacology. 40:1515-1522
The carbocyclic analog of 2'-deoxyguanosine [(+-)-2-amino-1,9-dihydro-9-[(1 alpha,3 beta,4 alpha)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-6H-purine-6-one] (2'-CDG) is highly active in cell culture against strains S148 and E377 of herpes simplex virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eadd65b1469f89a190ef774ee4e9d8f
https://doi.org/10.1016/0006-2952(90)90448-t
https://doi.org/10.1016/0006-2952(90)90448-t
Publikováno v:
Biochemical Pharmacology
Carbocyclic cytidine (C-Cyd) is a broad-spectrum antiviral agent active against DNA viruses [pox (vaccinia)], (+)RNA viruses [toga (Sindbis, Semliki forest), corona], (-)RNA viruses [orthomyxo (influenza), paramyxo (parainfluenza, measles), rhabdo (v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b1440ad9dde69e68d2589c95c268e0
Autor:
Brahma P. Sani, Jerry L. Frye, James M. Riordan, Linda Simpson-Herren, Y. Fulmer Shealy, Donald L. Hill
Publikováno v:
Journal of medicinal chemistry. 46(10)
The design of analogues of 7,8-dihydroretinoic acid (7,8-dihydro-RA) was based on reported biological activities of this retinoid and its dihydro-TMMP(1) analogue and on structural hypotheses. 7-Oxa-7,8-dihydroretinoids (5, 6) were prepared by O-alky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b105e4f95d10d4463de346d751e8d7
https://pubmed.ncbi.nlm.nih.gov/12723955
https://pubmed.ncbi.nlm.nih.gov/12723955